Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation
| Title: | Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation |
|---|---|
| Authors: | Coiffard B.; Prud'Homme E.; Hraiech S.; Cassir N.; Le Pavec J.; Kessler R.; Meloni F.; Leone M.; Thomas P. A.; Reynaud-Gaubert M.; Papazian L.; Aigner C.; Ali H.; Alvarez Moran A. M.; Astor T.; Aubert J. -D.; Bennett D.; Bertani A.; Betensley A.; Blanchard E.; Boussaud V.; Budev M.; Carney K.; Chambers D.; Chan K.; Chandrashekaran S.; Chen-Yoshikawa T.; Chida M.; Cifrian J.; Cornwell R.; Dilling D.; Doucette K.; Evrard P.; Falk J.; Garrity E.; Girgis R.; Glanville A.; Greer M.; Gries C.; Hachem R.; Hackmann A.; Hage C.; Havlin J.; Holm A. M.; Inci I.; Jaksch P.; Kennedy C.; Kilbourne S.; Klesney-Tait J.; Knoop C.; Krapf C.; Kubisa B.; Kwakkel-van Erp J. M.; Laisaar T.; Larsson H.; Le Borgne A.; Lee J.; Lepper P. M.; Levy R.; Loy M.; McWilliams T.; Miyazaki T.; Monforte V.; Montravers P.; Nathan S.; Costa A. N.; Nolde A.; Okada Y.; Osses J. M.; Paganelli G. M.; Paoletti L.; Park M. S.; Zarmar J.; Parulekar A.; Perch M.; Poirier C.; Puius Y.; Rabain A. -M.; Rampolla R.; Reed R.; Renaud-Picard B.; Riise G.; Robbins I.; Rosso L.; Roux A.; Saint-Raymond C.; Samuel J.; Schecter M.; Seminari E.; Shiraishi T.; Singer L.; Singer J.; Smud A.; Snell G.; Soccal P.; Tebaldi A.; Tissot A.; Tomic R.; Ussetti M. P.; van Duin D.; Vaquero J. M.; Venuta F.; Verschuuren E. A. M.; Vos R.; Wille K.; Yoshino I.; Yung G.; Zamora M. |
| Contributors: | Coiffard, B.; Prud'Homme, E.; Hraiech, S.; Cassir, N.; Le Pavec, J.; Kessler, R.; Meloni, F.; Leone, M.; Thomas, P. A.; Reynaud-Gaubert, M.; Papazian, L.; Aigner, C.; Ali, H.; Alvarez Moran, A. M.; Astor, T.; Aubert, J. -D.; Bennett, D.; Bertani, A.; Betensley, A.; Blanchard, E.; Boussaud, V.; Budev, M.; Carney, K.; Chambers, D.; Chan, K.; Chandrashekaran, S.; Chen-Yoshikawa, T.; Chida, M.; Cifrian, J.; Cornwell, R.; Dilling, D.; Doucette, K.; Evrard, P.; Falk, J.; Garrity, E.; Girgis, R.; Glanville, A.; Greer, M.; Gries, C.; Hachem, R.; Hackmann, A.; Hage, C.; Havlin, J.; Holm, A. M.; Inci, I.; Jaksch, P.; Kennedy, C.; Kilbourne, S.; Klesney-Tait, J.; Knoop, C.; Krapf, C.; Kubisa, B.; Kwakkel-van Erp, J. M.; Laisaar, T.; Larsson, H.; Le Borgne, A.; Lee, J.; Lepper, P. M.; Levy, R.; Loy, M.; Mcwilliams, T.; Miyazaki, T.; Monforte, V.; Montravers, P.; Nathan, S.; Costa, A. N.; Nolde, A.; Okada, Y.; Osses, J. M.; Paganelli, G. M.; Paoletti, L.; Park, M. S.; Zarmar, J.; Parulekar, A.; Perch, M.; Poirier, C.; Puius, Y.; Rabain, A. -M.; Rampolla, R.; Reed, R.; Renaud-Picard, B.; Riise, G.; Robbins, I.; Rosso, L.; Roux, A.; Saint-Raymond, C.; Samuel, J.; Schecter, M.; Seminari, E.; Shiraishi, T.; Singer, L.; Singer, J.; Smud, A.; Snell, G.; Soccal, P.; Tebaldi, A.; Tissot, A.; Tomic, R.; Ussetti, M. P.; van Duin, D. |
| Publisher Information: | Springer |
| Publication Year: | 2020 |
| Collection: | Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: | survey; lung transplantation; antibiotic therapy; perioperative; bronchial colonization |
| Description: | Background: Infection is the most common cause of mortality within the first year after lung transplantation (LTx). The management of perioperative antibiotic therapy is a major issue, but little is known about worldwide practices. Methods: We sent by email a survey dealing with 5 daily clinical vignettes concerning perioperative antibiotic therapy to 180 LTx centers around the world. The invitation and a weekly reminder were sent to lung transplant specialists for a single consensus answer per center during a 3-month period. Results: We received a total of 99 responses from 24 countries, mostly from Western Europe (n = 46) and the USA (n = 34). Systematic screening for bronchial recipient colonization before LTx was mostly performed with sputum samples (72%), regardless of the underlying lung disease. In recipients without colonization, antibiotics with activity against gram-negative bacteria resistant strains (piperacillin / tazobactam, cefepime, ceftazidime, carbapenems) were reported in 72% of the centers, and antibiotics with activity against methicillin-resistant Staphylococcus aureus (mainly vancomycin) were reported in 38% of the centers. For these recipients, the duration of antibiotics reported was 7 days (33%) or less (26%) or stopped when cultures of donor and recipients were reported negatives (12%). In recipients with previous colonization, antibiotics were adapted to the susceptibility of the most resistant strain and given for at least 14 days (67%). Conclusion: Practices vary widely around the world, but resistant bacterial strains are mostly targeted even if no colonization occurs. The antibiotic duration reported was longer for colonized recipients. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32349719; info:eu-repo/semantics/altIdentifier/wos/WOS:000531858700008; volume:20; issue:1; numberofpages:9; journal:BMC PULMONARY MEDICINE; https://hdl.handle.net/11573/1664388 |
| DOI: | 10.1186/s12890-020-1151-9 |
| Availability: | https://hdl.handle.net/11573/1664388; https://doi.org/10.1186/s12890-020-1151-9 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.D0B3FEA9 |
| Database: | BASE |