| Title: |
Current situation of solid organ transplantation from HIV-positive donors to HIV-positive recipients in Europe : the Spanish perspective |
| Authors: |
Miro, Jose M; Amondarain, Nerea L; Serrano, Lucia; Salmanton-Garcia, Jon; Manzardo, Christian; Malano-Barletta, Daniela; Paredes-Zapata, David; Guerra-Maio, Antonio; Stahl, Jean-Paul; Subirana, Marta; Ruiz, Pablo; Fondevila, Constantino; Cofán, Federic; González, Angela; Musquera, Mireia; Mahillo, Beatriz; de la Rosa, Gloria; Marazuela, Rosario; Rimola, Antonio; Moreno, Asuncion; Huis in 't Veld, Diana; on behalf the Spanish LT-KT in HIV-Infected Patients Working Group investigators and the UEMS-ID investigators, missing; European Union of Medical Specialists Section of Infectious Diseases (UEMS-ID) investigators, missing |
| Source: |
CLINICAL MICROBIOLOGY AND INFECTION ; ISSN: 1198-743X ; ISSN: 1469-0691 |
| Publication Year: |
2026 |
| Collection: |
Ghent University Academic Bibliography |
| Subject Terms: |
Medicine and Health Sciences; Europe; HIV-Positive donors; HIV-Positive recipients; Kidney transplantation; Liver transplantation; Spain; Survey; KIDNEY-TRANSPLANTATION; LIVER-TRANSPLANT; MULTICENTER; INFECTION; CARE |
| Description: |
Objectives: There is limited information on the use of organs from HIV-positive donors (HIV D+) for HIV-positive recipients (HIV R+) in Europe. In some countries, the use of HIV D+ organs is prohibited by law. This study aimed to assess the attitudes of Spanish kidney transplant (KT) and liver transplant (LT) teams towards HIV D+/R + KT/LT through a nationwide survey, and to evaluate the current situation across Europe regarding legislation and reported cases. Methods: In 2018 and 2019, 2 surveys were conducted across Spain's 24 LT and 39 KT centres, respectively. Specialists in HIV/infectious diseases, nephrology/hepatology, urology/liver surgery and transplant coordination completed a questionnaire, with responses analysed by speciality. We also consulted European representatives on national legal frameworks regarding HIV D+/R+ and conducted a narrative review of published cases (2000-2025). Results: The Spanish survey was answered by at least one member of all Spanish LT and KT teams (63/ 63, 100%). Most specialists who responded to the survey (167/252; 66%) supported using organs from virologically suppressed (VS) HIV D+ on antiretroviral therapy, high-risk and serodiscordant couples, but not from non-VS HIV D+, for HIV R+. All respondents endorsed implementing a dedicated consent form, and a majority expressed willingness to participate in an HIV D+/R+ trial. No major differences were observed between the LT and KT teams. At the European level, the use of organs from HIV D+ was permitted, prohibited or unregulated in 6 (17%), 11 (31.5%) and 18 (51.5%) countries, respectively. Ten HIV D+/R+ transplants (6 kidneys and 4 livers) have been published, with good 1-year outcomes. Discussion: The surveyed Spanish specialists would agree on using organs from VS HIV D+ for HIV D+/ R+ transplants. This procedure is only legally allowed in very few European countries. These results should promote changes in donor laws across Europe. Jose M. Miro, dlin Microbiol Infect 2026;32:137 (c) 2025 European Society of Clinical ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://biblio.ugent.be/publication/01K6033ZWP7GX40MHZREG8P4RE; https://doi.org/10.1016/j.cmi.2025.08.025; https://biblio.ugent.be/publication/01K6033ZWP7GX40MHZREG8P4RE/file/01K603FN3KMXB9ZZM04AP502J5 |
| DOI: |
10.1016/j.cmi.2025.08.025 |
| Availability: |
https://biblio.ugent.be/publication/01K6033ZWP7GX40MHZREG8P4RE; https://hdl.handle.net/1854/LU-01K6033ZWP7GX40MHZREG8P4RE; https://doi.org/10.1016/j.cmi.2025.08.025; https://biblio.ugent.be/publication/01K6033ZWP7GX40MHZREG8P4RE/file/01K603FN3KMXB9ZZM04AP502J5 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.D0E3B4F9 |
| Database: |
BASE |