| Title: |
Insights into adherence to medication and lifestyle recommendations in an international cohort of patients with catecholaminergic polymorphic ventricular tachycardia. |
| Authors: |
Peltenburg, PJ; van den Heuvel, LM; Kallas, D; Bell, C; Denjoy, I; Behr, ER; Field, E; Kammeraad, JAE; Yap, S-C; Probst, V; Ackerman, MJ; Blom, NA; Wilde, AAM; Clur, S-AB; van der Werf, C |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2024 |
| Collection: |
St George's University of London: Repository |
| Description: |
AIMS: In patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), a rare inherited arrhythmia syndrome, arrhythmic events can be prevented by medication and lifestyle recommendations. In patients who experience breakthrough arrhythmic events, non-adherence plays an essential role. We aimed to investigate the incidence and potential reasons for non-adherence to medication and lifestyle recommendations in a large, international cohort of patients with CPVT. METHODS AND RESULTS: An online multilingual survey was shared with CPVT patients worldwide by their cardiologists, through peer-recruitment, and on social media from November 2022 until July 2023. Self-reported non-adherence was measured using the validated Medication Adherence Rating Scale (MARS) and a newly developed questionnaire about lifestyle. Additionally, validated questionnaires were used to assess potential reasons for medication non-adherence. Two-hundred-and-eighteen patients completed the survey, of whom 200 (92%) were prescribed medication [122 (61%) female; median age 33.5 years (interquartile range: 22-50)]. One-hundred-and-three (52%) were prescribed beta-blocker and flecainide, 85 (43%) beta-blocker, and 11 (6%) flecainide. Thirty-four (17%) patients experienced a syncope, aborted cardiac arrest or appropriate implantable cardioverter defibrillator shock after diagnosis. Nineteen (13.4%) patients were exercising more than recommended. Thirty (15%) patients were non-adherent to medication. Female sex [odds ratio (OR) 3.7, 95% confidence interval (CI) 1.3-12.0, P = 0.019], flecainide monotherapy compared to combination therapy (OR 6.8, 95% CI 1.6-31.0, P = 0.010), and a higher agreement with statements regarding concerns about CPVT medication (OR 1.2, 95% CI 1.1-1.3, P < 0.001) were independently associated with non-adherence. CONCLUSION: The significant rate of non-adherence associated with concerns regarding CPVT-related medication, emphasizes the potential for improving therapy adherence by targeted patient education. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1532-2092 |
| Relation: |
https://openaccess.sgul.ac.uk/id/eprint/116230/6/euae044.pdf; https://openaccess.sgul.ac.uk/id/eprint/116230/11/euae044_supplementary_data.pdf; https://openaccess.sgul.ac.uk/id/eprint/116230/1/euae044.pdf; Peltenburg, PJ; van den Heuvel, LM; Kallas, D; Bell, C; Denjoy, I; Behr, ER; Field, E; Kammeraad, JAE; Yap, S-C; Probst, V; et al. Peltenburg, PJ; van den Heuvel, LM; Kallas, D; Bell, C; Denjoy, I; Behr, ER; Field, E; Kammeraad, JAE; Yap, S-C; Probst, V; Ackerman, MJ; Blom, NA; Wilde, AAM; Clur, S-AB; van der Werf, C (2024) Insights into adherence to medication and lifestyle recommendations in an international cohort of patients with catecholaminergic polymorphic ventricular tachycardia. Europace, 26 (2). euae044. ISSN 1532-2092 https://doi.org/10.1093/europace/euae044 SGUL Authors: Behr, Elijah Raphael |
| DOI: |
10.1093/europace/euae044 |
| Availability: |
https://openaccess.sgul.ac.uk/id/eprint/116230/; https://openaccess.sgul.ac.uk/id/eprint/116230/6/euae044.pdf; https://openaccess.sgul.ac.uk/id/eprint/116230/11/euae044_supplementary_data.pdf; https://openaccess.sgul.ac.uk/id/eprint/116230/1/euae044.pdf; https://doi.org/10.1093/europace/euae044 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.D0E6F112 |
| Database: |
BASE |