Variants associated with HHIP expression have sex-differential effects on lung function
| Title: | Variants associated with HHIP expression have sex-differential effects on lung function |
|---|---|
| Authors: | KA Fawcett; LV Wain; M Obeidat; C Melbourne; N Shrine; AL Guyatt; C John; J Luan; A Richmond; MR Moksnes; R Granell; S Weiss; M Imboden; S May-Wilson; P Hysi; TS Boutin; L Portas; C Flexeder; SE Harris; CA Wang; LP Lyytikäinen; T Palviainen; RE Foong; D Keidel; C Minelli; C Langenberg; Y Bossé; M Van den Berge; DD Sin; K Hao; A Campbell; D Porteous; S Padmanabhan; BH Smith; DM Evans; S Ring; A Langhammer; K Hveem; C Willer; R Ewert; B Stubbe; N Pirastu; L Klaric; PK Joshi; K Patasova; M Massimo; O Polasek; JM Starr; S Karrasch; K Strauch; T Meitinger; I Rudan; T Rantanen; K Pietiläinen; M Kähönen; OT Raitakari; GL Hall; PD Sly; CE Pennell; J Kaprio; T Lehtimäki; V Vitart; IJ Deary; D Jarvis; JF Wilson; T Spector; N Probst-Hensch; NJ Wareham; H Völzke; J Henderson; DP Strachan; BM Brumpton; C Hayward; IP Hall; MD Tobin |
| Publication Year: | 2021 |
| Subject Terms: | Expression; Genome-wide interaction study; HHIP; Lung function; Sex; 3202 Clinical sciences; 3205 Medical biochemistry and metabolomics |
| Description: | Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| Relation: | http://hdl.handle.net/10536/DRO/DU:30164811 |
| Availability: | http://hdl.handle.net/10536/DRO/DU:30164811; https://figshare.com/articles/journal_contribution/Variants_associated_with_HHIP_expression_have_sex-differential_effects_on_lung_function/20611308 |
| Rights: | All Rights Reserved |
| Accession Number: | edsbas.D0EAAFD2 |
| Database: | BASE |