| Title: |
Anti-Mullerian Hormone Predicts Menopause: A Long-Term Follow-Up Study in Normoovulatory Women |
| Authors: |
Broer, SL; Eijkemans, Rene; Scheffer, GJ; van Rooij, IAJ; de Vet, A (Annemarie); Themmen, Axel; Laven, Joop; Jong, Frank; Velde, ERT; Fauser, BC; Broekmans, FJM |
| Source: |
Broer, SL, Eijkemans, R, Scheffer, GJ, van Rooij, IAJ, de Vet, A, Themmen, A, Laven, J, Jong, F, Velde, ERT, Fauser, BC & Broekmans, FJM 2011, 'Anti-Mullerian Hormone Predicts Menopause: A Long-Term Follow-Up Study in Normoovulatory Women', Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 8, pp. 2532-2539. |
| Publication Year: |
2011 |
| Subject Terms: |
/dk/atira/pure/keywords/researchprograms/AFL001000/EMCMM015207; name=EMC MM-01-52-07; /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being |
| Description: |
Context: It has been hypothesized that a fixed interval exists between age at natural sterility and age at menopause. Both events show considerable individual variability, with a range of 20 yr. Correct prediction of age at menopause could open avenues of individualized prevention of age-related infertility and other menopause-related conditions, like cardiovascular disease and breast carcinoma. Objective: The aim of this study was to explore the ability of ovarian reserve tests to predict age at menopause. Design and Setting: We conducted a long-term follow-up study at an academic hospital. Participants: A total of 257 normoovulatory women (age, 21-46 yr) were derived from three cohorts with highly comparable selection criteria. Interventions: Anti-Mullerian hormone (AMH), antral follicle count, and FSH were assessed at time 1 (T1). At time 2 (T2), approximately 11 yr later, cycle status (strictly regular, menopausal transition, or postmenopause) and age at menopause were inventoried. Main Outcome Measures: Accuracy of the ovarian reserve tests in predicting time to menopause was assessed by Cox regression, and a nomogram was constructed for the relationship between age-specific AMH concentrations at T1 and age at menopause. Results: A total of 48 (19%) women had reached postmenopause at T2. Age, AMH, and antral follicle count at T1 were significantly related with time to menopause (P < 0.001) and showed a good percentage of correct predictions (C-statistic, 0.87, 0.86, and 0.84, respectively). After adjusting for age, only AMH added to this prediction (C-statistic, 0.90). From the constructed nomogram, it appeared that the normal distribution of age at menopause will shift considerably, depending on the individual Conclusions: AMH is highly predictive for timing of menopause. Using age and AMH, the age range in which menopause will subsequently occur can be individually calculated. (J Clin Endocrinol Metab 96: 2532-2539, 2011) |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| ISSN: |
0021-972X; 1945-7197 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pissn/0021-972X; info:eu-repo/semantics/altIdentifier/eissn/1945-7197 |
| Availability: |
https://pure.eur.nl/en/publications/21776b61-9327-46c8-bf2f-da57a829a099 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| Accession Number: |
edsbas.D0F7AD39 |
| Database: |
BASE |