| Title: |
Venom peptides: promising tools for lung cancer imaging |
| Authors: |
Baudat, Romain; Benoit, Evelyne; Keck, Mathilde; Kessler, Pascal; Truillet, Charles; Servent, Denis |
| Contributors: |
Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) (SIMoS); Médicaments et Technologies pour la Santé (MTS); Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Service d'ingénierie moléculaire des protéines (SIMOPRO); Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS); LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay (BIOMAPS); Service Hospitalier Frédéric Joliot (SHFJ); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Source: |
Journées scientifiques croisées des programmes Focus Organoïdes sur Puce et Focus Biomarqueurs ; https://hal.science/hal-04474222 ; Journées scientifiques croisées des programmes Focus Organoïdes sur Puce et Focus Biomarqueurs, Oct 2023, Gif-sur-Yvette, France |
| Publisher Information: |
CCSD |
| Publication Year: |
2023 |
| Subject Terms: |
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology; [SDV.CAN]Life Sciences [q-bio]/Cancer |
| Subject Geographic: |
Gif-sur-Yvette; France |
| Description: |
National audience ; Many cancers, and the non-small cell lung cancer (NSCLC) in particular, are associated with significant overexpression of various ion channels such as certain subtypes of sodium, calcium and potassium channels, pH-sensitive channels (ASICs for acid sensing ion channels) or nicotinic acetylcholine receptors. Activation of these ion channels plays an important role in the aggressiveness of cancer cell and tumor invasion, their overexpression seeming to be correlated with the appearance of metastases. Although imaging approaches (radiography, CT-scan for computed tomography scanning, PET-scan for positron emission tomography) are commonly used in the anatomical characterization of lung cancer, some limitations of these approaches require the development of new imaging probes more specific of overexpressed molecular targets in lung adenocarcinomas. Peptide toxins, which possess unique pharmacological properties, are well known to act selectively and with high affinity on certain overexpressed ion channels in cancer cells. Therefore, a promising solution towards the development of new imaging agents oflung cancer biomarkers appears to be the chemical synthesis of these toxins allowing them to be labelled by “click” chemistry using various fluorescent or radioactive probes. |
| Document Type: |
conference object; still image |
| Language: |
English |
| Availability: |
https://hal.science/hal-04474222; https://hal.science/hal-04474222v1/document; https://hal.science/hal-04474222v1/file/JourneesBiomarqueurs-23_BAUDAT-Po.pdf |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.D12876A4 |
| Database: |
BASE |