| Title: |
Different PD-MCI criteria and risk of dementia in Parkinson’s disease: 4-year longitudinal study |
| Authors: |
Wood KL; Myall DJ; Livingston L; Melzer TR; Pitcher TL; MacAskill MR; Geurtsen GJ; Anderson TJ; Dalrymple-Alford JC |
| Publication Year: |
2018 |
| Collection: |
University of Canterbury, Christchurch: UC Research Repository |
| Subject Terms: |
Field of Research::11 - Medical and Health Sciences::1109 - Neurosciences::110904 - Neurology and Neuromuscular Diseases; Field of Research::17 - Psychology and Cognitive Sciences::1702 - Cognitive Science |
| Description: |
The Movement Disorder Society Task Force (MDS-TF) has proposed diagnostic criteria for mild cognitive impairment in Parkinson's disease (PD-MCI). We hypothesized that the risk of dementia (PDD) varies across the different cutoff schemes allowed. A longitudinal study followed 121 non-demented PD patients for up to 4.5 years. In Part One, unique groups of patients were identified as PD-MCI at baseline using the MDS-TF requirement of two impaired cognitive test scores, with both scores classified as impaired at either (i) 2 s.d., (ii) 1.5 s.d. or (iii) 1 s.d. below normative data; relative risk (RR) of PDD was assessed at each criterion. In Part Two, the whole sample was reassessed and (i) RR of PDD determined when two impairments at 1.5 s.d. existed within a single cognitive domain, followed by (ii) RR of PDD in the unique group whose two impairments at 1.5 s.d. did not exist within a single domain (i.e., only across two domains). Twenty-one percent of patients converted to PDD. Part One showed that the 1.5 s.d. criterion at baseline is optimal to maximize progression to PDD over 4 years. Part Two, however, showed that the 1.5 s.d. cutoff produced a high RR of PDD only when two impairments were identified within a single cognitive domain (7.2, 95% confidence interval (CI)=3.4-16.6, P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://hdl.handle.net/10092/15720; https://doi.org/10.1038/npjparkd.2015.27 |
| DOI: |
10.1038/npjparkd.2015.27 |
| Availability: |
http://hdl.handle.net/10092/15720; https://doi.org/10.1038/npjparkd.2015.27 |
| Rights: |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/ by/4.0/ |
| Accession Number: |
edsbas.D12F2383 |
| Database: |
BASE |