| Title: |
Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates |
| Authors: |
Katerberg, Hilga; Delucchi, Kevin L.; Stewart, S. Evelyn; Lochner, Christine; Denys, Damiaan A. J. P.; Stack, Denise E.; Andresen, Joshua Michael; Grant, J. E.; Kim, Suck W.; Williams, Kyle A.; den Boer, Johan A.; van Balkom, Anton J. L. M.; Smit, Johannes H.; van Oppen, Patricia; Polman, Annemiek; Jenike, Michael A.; Stein, Dan J.; Mathews, Carol A.; Cath, Danielle C. |
| Contributors: |
Massachusetts Institute of Technology. Department of Chemical Engineering; Andresen, Joshua Michael |
| Source: |
Springer |
| Publisher Information: |
Springer Science + Business Media B.V. |
| Publication Year: |
2009 |
| Collection: |
DSpace@MIT (Massachusetts Institute of Technology) |
| Description: |
To reduce the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) for genetic, clinical and translational studies, numerous factor analyses of the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have been conducted. Results of these analyses have been inconsistent, likely as a consequence of small sample sizes and variable methodologies. Furthermore, data concerning the heritability of the factors are limited. Item and category-level factor analyses of YBOCS-CL items from 1224 OCD subjects were followed by heritability analyses in 52 OCD-affected multigenerational families. Item-level analyses indicated that a five factor model: (1) taboo, (2) contamination/cleaning, (3) doubts, (4) superstitions/rituals, and (5) symmetry/hoarding provided the best fit, followed by a one-factor solution. All 5 factors as well as the one-factor solution were found to be heritable. Bivariate analyses indicated that the taboo and doubts factor, and the contamination and symmetry/hoarding factor share genetic influences. Contamination and symmetry/hoarding show shared genetic variance with symptom severity. Nearly all factors showed shared environmental variance with each other and with symptom severity. These results support the utility of both OCD diagnosis and symptom dimensions in genetic research and clinical contexts. Both shared and unique genetic influences underlie susceptibility to OCD and its symptom dimensions. ; Obsessive Compulsive Foundation ; Tourette Syndrome Association ; Anxiety Disorders Association of America ; American Academy of Child and Adolescent Psychiatry |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://dx.doi.org/10.1007/s10519-010-9339-z; Behavior Genetics; https://hdl.handle.net/1721.1/65885 |
| Availability: |
https://hdl.handle.net/1721.1/65885 |
| Rights: |
Creative Commons Attribution Noncommercial License ; http://creativecommons.org/licenses/by-nc/2.5 |
| Accession Number: |
edsbas.D1CE79CD |
| Database: |
BASE |