| Title: |
Interferon-epsilon is a novel regulator of NK cell responses in the uterus |
| Authors: |
Mayall, Jemma R.; Horvat, Jay C.; de Geus, Eveline D.; Starkey, Malcolm R.; Kim, Richard Y.; Daly, Katie; Goggins, Bridie J.; Keely, Simon; Maltby, Steven; Baldwin, Rennay; Foster, Paul S.; Boyle, Michael J.; Mangan, Niamh E.; Tanwar, Pradeep S.; Huntington, ND; Hertzog, PJ; Hansbro, Philip M.; Chevalier, Anne; McCarthy, Huw; Hampsey, Daniel; Donovan, Chantal; Brown, Alexandra C.; Matthews, Antony Y.; de Weerd, Nicole A. |
| Contributors: |
The University of Newcastle. College of Health, Medicine & Wellbeing, School of Biomedical Sciences and Pharmacy |
| Publisher Information: |
Wiley-Blackwell |
| Publication Year: |
2024 |
| Collection: |
NOVA: The University of Newcastle Research Online (Australia) |
| Subject Terms: |
interferon-epsilon; type I interferon; natural killer cell; female reproductive tract; chlamydia infection |
| Description: |
The uterus is a unique mucosal site where immune responses are balanced to be permissive of a fetus, yet protective against infections. Regulation of natural killer (NK) cell responses in the uterus during infection is critical, yet no studies have identified uterine-specific factors that control NK cell responses in this immune-privileged site. We show that the constitutive expression of IFNε in the uterus plays a crucial role in promoting the accumulation, activation, and IFNγ production of NK cells in uterine tissue during Chlamydia infection. Uterine epithelial IFNε primes NK cell responses indirectly by increasing IL-15 production by local immune cells and directly by promoting the accumulation of a pre-pro-like NK cell progenitor population and activation of NK cells in the uterus. These findings demonstrate the unique features of this uterine-specific type I IFN and the mechanisms that underpin its major role in orchestrating innate immune cell protection against uterine infection. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
NHMRC.1059242 http://purl.org/au-research/grants/nhmrc/1059242 & 1003591 http://purl.org/au-research/grants/nhmrc/1003591 & 1079187 http://purl.org/au-research/grants/nhmrc/1079187; EMBO Molecular Medicine Vol. 16, Issue 2, p. 267-293; http://hdl.handle.net/1959.13/1505685; uon:55703 |
| Availability: |
http://hdl.handle.net/1959.13/1505685 |
| Accession Number: |
edsbas.D1D0E6DF |
| Database: |
BASE |