| Title: |
Persistence of effector memory Th1 cells is regulated by Hopx |
| Authors: |
Albrecht, Inka; Niesner, Uwe; Janke, Marko; Menning, Astrid; Loddenkemper, Christoph; Kühl, Anja A.; Lepenies, Inga; Lexberg, Maria H.; Westendorf, Kerstin; Hradilkova, Kristyna; Grün, Joachim; Hamann, Alf; Epstein, Jonathan A.; Chang, Hyun‐Dong; Tokoyoda, Koji; Radbruch, Andreas |
| Source: |
European Journal of Immunology ; volume 40, issue 11, page 2993-3006 ; ISSN 0014-2980 1521-4141 |
| Publisher Information: |
Wiley |
| Publication Year: |
2010 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Th1 cells are prominent in inflamed tissue, survive conventional immunosuppression, and are believed to play a pivotal role in driving chronic inflammation. Here, we identify homeobox only protein (Hopx) as a critical and selective regulator of the survival of Th1 effector/memory cells, both in vitro and in vivo . Expression of Hopx is induced by T‐bet and increases upon repeated antigenic restimulation of Th1 cells. Accordingly, the expression of Hopx is low in peripheral, naïve Th cells, but highly up‐regulated in terminally differentiated effector/memory Th1 cells of healthy human donors. In murine Th1 cells, Hopx regulates the expression of genes involved in regulation of apoptosis and survival and makes them refractory to Fas‐induced apoptosis. In vivo , adoptively transferred Hopx‐deficient murine Th1 cells do not persist. Consequently, they cannot induce chronic inflammation in murine models of transfer‐induced colitis and arthritis, demonstrating a key role of Hopx for Th1‐mediated immunopathology. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/eji.201040936 |
| Availability: |
https://doi.org/10.1002/eji.201040936; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Feji.201040936; https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.201040936 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.D1D112CF |
| Database: |
BASE |