Hyaluronic Acid Levels Predict Risk of Hepatic Encephalopathy and Liver-Related Death in HIV/Viral Hepatitis Coinfected Patients
| Title: | Hyaluronic Acid Levels Predict Risk of Hepatic Encephalopathy and Liver-Related Death in HIV/Viral Hepatitis Coinfected Patients |
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| Authors: | Peters L.; Mocroft A.; Soriano V.; Rockstroh J.; Rauch A.; Karlsson A.; Knysz B.; Pradier C.; Zilmer K.; Lundgren J. D.; Losso M.; Kundro M.; Vetter N.; Zangerle R.; Karpov I.; Vassilenko A.; Mitsura V. M.; Suetnov O.; Clumeck N.; De Wit S.; Delforge M.; Colebunders R.; Vandekerckhove L.; Hadziosmanovic V.; Kostov K.; Begovac J.; Machala L.; Jilich D.; Sedlacek D.; Nielsen J.; Kronborg G.; Benfield T.; Larsen M.; Gerstoft J.; Katzenstein T.; Hansen A. -B. E.; Skinhoj P.; Pedersen C.; Ostergaard L.; Smidt J.; Ristola M.; Katlama C.; Viard J. -P.; Girard P. -M.; Livrozet J. M.; Vanhems P.; Dabis F.; Neau D.; Schmidt R.; van Lunzen J.; Degen O.; Stellbrink H. J.; Staszewski S.; Bogner J.; Fatkenheuer G.; Kosmidis J.; Gargalianos P.; Xylomenos G.; Perdios J.; Panos G.; Filandras A.; Karabatsaki E.; Sambatakou H.; Banhegyi D.; Mulcahy F.; Yust I.; Turner D.; Burke M.; Pollack S.; Hassoun G.; Maayan S.; Vella S.; Esposito R.; Mazeu I.; Mussini C.; Arici C.; Pristera R.; Mazzotta F.; Gabbuti A.; Vullo V.; Lichtner M.; Chirianni A.; Montesarchio E.; Gargiulo M.; Antonucci G.; Testa A.; Doffizi G.; Vlassi C.; Zaccarelli M.; Antorini A.; Lazzarin A.; Castagna A.; Gianotti N.; Galli M.; Ridolfo A.; d'Arminio Monforte A.; Rozentale B.; Zeltina I.; Chaplinskas S.; Staub T.; Hemmer R.; Reiss P.; Ormaasen V.; Maeland A.; Bruun J.; Gasiorowski J.; Horban A.; Bakowska E.; Grzeszczuk A.; Flisiak R.; Boron-Kaczmarska A.; Pynka M.; Parczewski M.; Beniowski M.; Mularska E.; Trocha H.; Jablonowska E.; Malolepsza E.; Wojcik K.; Antunes F.; Doroana M.; Caldeira L.; Mansinho K.; Maltez F.; Duiculescu D.; Rakhmanova A.; Zakharova N.; Buzunova S.; Jevtovic D.; Mokras M.; Stanekova D.; Tomazic J.; Gonzalez-Lahoz J.; Labarga P.; Medrano J.; Moreno S.; Rodriguez J. M.; Clotet B.; Jou A.; Paredes R.; Tural C.; Puig J.; Bravo I.; Gatell J. M.; Miro J. M.; Domingo P.; Gutierrez M.; Mateo G.; Sambeat M. A.; Blaxhult A.; Flamholc L.; Ledergerber B.; Weber R.; Francioli P.; Cavassini M.; Hirschel B.; Boffi E.; Furrer H.; Battegay M.; Elzi L.; Kravchenko E.; Chentsova N.; Frolov V.; Kutsyna G.; Servitskiy S.; Krasnov M.; Barton S.; Johnson A. M.; Mercey D.; Phillips A.; Johnson M. A.; Murphy M.; Weber J.; Scullard G.; Fisher M.; Leen C. |
| Contributors: | L. Peter; A. Mocroft; V. Soriano; J. Rockstroh; A. Rauch; A. Karlsson; B. Knysz; C. Pradier; K. Zilmer; J.D. Lundgren; M. Losso; M. Kundro; N. Vetter; R. Zangerle; I. Karpov; A. Vassilenko; V.M. Mitsura; O. Suetnov; N. Clumeck; S. De Wit; M. Delforge; R. Colebunder; L. Vandekerckhove; V. Hadziosmanovic; K. Kostov; J. Begovac; L. Machala; D. Jilich; D. Sedlacek; J. Nielsen; G. Kronborg; T. Benfield; M. Larsen; J. Gerstoft; T. Katzenstein; A.-.E. Hansen; P. Skinhoj; C. Pedersen; L. Ostergaard; J. Smidt; M. Ristola; C. Katlama; J.-. Viard; P.-. Girard; J.M. Livrozet; P. Vanhem; F. Dabi; D. Neau; R. Schmidt; J. van Lunzen; O. Degen; H.J. Stellbrink; S. Staszewski; J. Bogner; G. Fatkenheuer; J. Kosmidi; P. Gargaliano; G. Xylomeno; J. Perdio; G. Pano; A. Filandra; E. Karabatsaki; H. Sambatakou; D. Banhegyi; F. Mulcahy; I. Yust; D. Turner; M. Burke; S. Pollack; G. Hassoun; S. Maayan; S. Vella; R. Esposito; I. Mazeu; C. Mussini; C. Arici; R. Pristera; F. Mazzotta; A. Gabbuti; V. Vullo; M. Lichtner; A. Chirianni; E. Montesarchio; M. Gargiulo; G. Antonucci; A. Testa; G. Doffizi; C. Vlassi; M. Zaccarelli; A. Antorini; A. Lazzarin; A. Castagna; N. Gianotti; M. Galli; A. Ridolfo; A. d'Arminio Monforte; B. Rozentale; I. Zeltina; S. Chaplinska; T. Staub |
| Publisher Information: | Public Library of Science |
| Publication Year: | 2013 |
| Collection: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: | Adult; Biomarker; Coinfection; Disease Progression; Female; Follow-Up Studie; HIV Infection; Hepatic Encephalopathy; Hepatitis; Viral; Human; Hyaluronic Acid; Incidence; Male; Middle Aged; Prognosi; Prospective Studie; ROC Curve; Risk Assessment; Young Adult; Settore MED/17 - Malattie Infettive |
| Description: | Background:Whereas it is well established that various soluble biomarkers can predict level of liver fibrosis, their ability to predict liver-related clinical outcomes is less clearly established, in particular among HIV/viral hepatitis co-infected persons. We investigated plasma hyaluronic acid's (HA) ability to predict risk of liver-related events (LRE; hepatic coma or liver-related death) in the EuroSIDA study.Methods:Patients included were positive for anti-HCV and/or HBsAg with at least one available plasma sample. The earliest collected plasma sample was tested for HA (normal range 0-75 ng/mL) and levels were associated with risk of LRE. Change in HA per year of follow-up was estimated after measuring HA levels in latest sample before the LRE for those experiencing this outcome (cases) and in a random selection of one sixth of the remaining patients (controls).Results:During a median of 8.2 years of follow-up, 84/1252 (6.7%) patients developed a LRE. Baseline median (IQR) HA in those without and with a LRE was 31.8 (17.2-62.6) and 221.6 ng/mL (74.9-611.3), respectively (p |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/23724041; info:eu-repo/semantics/altIdentifier/wos/WOS:000319738100023; volume:8; issue:5; firstpage:1; lastpage:10; numberofpages:10; journal:PLOS ONE; https://hdl.handle.net/2434/774457 |
| DOI: | 10.1371/journal.pone.0064283 |
| Availability: | https://hdl.handle.net/2434/774457; https://doi.org/10.1371/journal.pone.0064283 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.D1EF17B9 |
| Database: | BASE |