| Title: |
Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions |
| Authors: |
Dareng, Eileen O; Coetzee, Simon G; Tyrer, Jonathan P; Peng, Pei-Chen; Rosenow, Will; Chen, Stephanie; Davis, Brian D; Dezem, Felipe Segato; Seo, Ji-Heui; Nameki, Robbin; Reyes, Alberto L; Aben, Katja KH; Anton-Culver, Hoda; Antonenkova, Natalia N; Aravantinos, Gerasimos; Bandera, Elisa V; Beane Freeman, Laura E; Beckmann, Matthias W; Beeghly-Fadiel, Alicia; Benitez, Javier; Bernardini, Marcus Q; Bjorge, Line; Black, Amanda; Bogdanova, Natalia V; Bolton, Kelly L; Brenton, James D; Budzilowska, Agnieszka; Butzow, Ralf; Cai, Hui; Campbell, Ian; Cannioto, Rikki; Chang-Claude, Jenny; Chanock, Stephen J; Chen, Kexin; Chenevix-Trench, Georgia; AOCS, Group; Chiew, Yoke-Eng; Cook, Linda S; DeFazio, Anna; Dennis, Joe; Doherty, Jennifer A; Dörk, Thilo; du Bois, Andreas; Dürst, Matthias; Eccles, Diana M; Ene, Gabrielle; Fasching, Peter A; Flanagan, James M; Fortner, Renée T; Fostira, Florentia; Gentry-Maharaj, Aleksandra; Giles, Graham G; Goodman, Marc T; Gronwald, Jacek; Haiman, Christopher A; Håkansson, Niclas; Heitz, Florian; Hildebrandt, Michelle AT; Høgdall, Estrid; Høgdall, Claus K; Huang, Ruea-Yea; Jensen, Allan; Jones, Michael E; Kang, Daehee; Karlan, Beth Y; Karnezis, Anthony N; Kelemen, Linda E; Kennedy, Catherine J; Khusnutdinova, Elza K; Kiemeney, Lambertus A; Kjaer, Susanne K; Kupryjanczyk, Jolanta; Labrie, Marilyne; Lambrechts, Diether; Larson, Melissa C; Le, Nhu D; Lester, Jenny; Li, Lian; Lubiński, Jan; Lush, Michael; Marks, Jeffrey R; Matsuo, Keitaro; May, Taymaa; McLaughlin, John R; McNeish, Iain A; Menon, Usha; Missmer, Stacey; Modugno, Francesmary; Moffitt, Melissa; Monteiro, Alvaro N; Moysich, Kirsten B; Narod, Steven A; Nguyen-Dumont, Tu; Odunsi, Kunle; Olsson, Håkan; Onland-Moret, N Charlotte; Park, Sue K; Pejovic, Tanja; Permuth, Jennifer B; Piskorz, Anna; Prokofyeva, Darya; Riggan, Marjorie J; Risch, Harvey A; Rodríguez-Antona, Cristina; Rossing, Mary Anne; Sandler, Dale P; Setiawan, V Wendy; Shan, Kang; Song, Honglin; Southey, Melissa C; Steed, Helen; Sutphen, Rebecca; Swerdlow, Anthony J; Teo, Soo Hwang; Terry, Kathryn L; Thompson, Pamela J; Vestrheim Thomsen, Liv Cecilie; Titus, Linda; Trabert, Britton; Travis, Ruth; Tworoger, Shelley S; Valen, Ellen; Van Nieuwenhuysen, Els; Edwards, Digna Velez; Vierkant, Robert A; Webb, Penelope M; OPAL Study, Group; Weinberg, Clarice R; Weise, Rayna Matsuno; Wentzensen, Nicolas; White, Emily; Winham, Stacey J; Wolk, Alicja; Woo, Yin-Ling; Wu, Anna H; Yan, Li; Yannoukakos, Drakoulis; Zeinomar, Nur; Zheng, Wei; Ziogas, Argyrios; Berchuck, Andrew; Goode, Ellen L; Huntsman, David G; Pearce, Celeste L; Ramus, Susan J; Sellers, Thomas A; Ovarian Cancer Association Consortium, (OCAC); Freedman, Matthew L; Lawrenson, Kate; Schildkraut, Joellen M; Hazelett, Dennis; Plummer, Jasmine T; Kar, Siddhartha; Jones, Michelle R; Pharoah, Paul DP; Gayther, Simon A |
| Source: |
American Journal of Human Genetics , 111 (6) pp. 1061-1083. (2024) |
| Publisher Information: |
Elsevier |
| Publication Year: |
2024 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
epithelial ovarian cancer risk; fine mapping; functional mechanisms; GWAS |
| Description: |
To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases and 105,724 controls of European origin. We identified five histotype-specific EOC risk regions (p value |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10194088/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10194088/1/Jones_Integrative%20multi-omics%20analyses%20to%20identify%20the%20genetic%20and%20functional%20mechanisms%20underlying%20ovarian%20cancer%20risk%20regions_AAM.pdf; https://discovery.ucl.ac.uk/id/eprint/10194088/ |
| Rights: |
open |
| Accession Number: |
edsbas.D1F19312 |
| Database: |
BASE |