| Title: |
Dopamine D2/3R availability after discontinuation of antipsychotic treatment:a [11C]raclopride PET study in remitted first-episode psychosis patients. |
| Authors: |
de Beer, Franciska; de Vries, Erik; Wijnen, Ben; Begemann, Marieke J H; van Beveren, Nico; Boonstra, Nynke; Gangadin, Shiral S; de Haan, Lieuwe; Hamers, Iris M H; Veling, Wim; Koops, Sanne; Sommer, Iris E C |
| Source: |
de Beer, F, de Vries, E, Wijnen, B, Begemann, M J H, van Beveren, N, Boonstra, N, Gangadin, S S, de Haan, L, Hamers, I M H, Veling, W, Koops, S & Sommer, I E C 2025, 'Dopamine D2/3R availability after discontinuation of antipsychotic treatment : a [11C]raclopride PET study in remitted first-episode psychosis patients.', Psychological Medicine, vol. 55, e264. https://doi.org/10.1017/S003329172510161X |
| Publication Year: |
2025 |
| Collection: |
University of Groningen research database |
| Subject Terms: |
Humans; Positron-Emission Tomography; Male; Antipsychotic Agents/therapeutic use; Female; Adult; Raclopride; Psychotic Disorders/drug therapy; Receptors; Dopamine D2/metabolism; Dopamine D3/metabolism; Young Adult; Recurrence; Dopamine D2 Receptor Antagonists; Corpus Striatum/metabolism; Case-Control Studies |
| Description: |
BACKGROUND: After remission of a first-episode psychosis (FEP), antipsychotic discontinuation is associated with an increased risk of relapse compared to maintenance treatment. We studied short and longer-term effects of discontinuation of D 2 receptor (D 2R) antagonist and partial agonist antipsychotics on striatal dopamine D 2/3R availability in FEP patients. METHODS: Remitted FEP patients underwent two [ 11C]raclopride PET scans to measure striatal D 2/3R availability: 1 week after antipsychotic discontinuation (n = 16 antagonist users, n = 6 partial agonist users) and after being medication free for 6-8 weeks (n = 8 antagonist users, n = 5 partial agonist users). Fifteen matched healthy controls were scanned once. Psychotic relapse was monitored up to 12 months after discontinuation. RESULTS: One week after discontinuation, D 2R antagonist discontinuers showed higher striatal binding potential (BP ND) than partial D 2R agonist discontinuers ( p < 0.001, CI=0.749 to 1.681) and controls ( p=0.045, CI=0.008 to 0.708), while partial agonist discontinuers had significantly lower BP ND than controls ( p=0.001, CI=-1.326 to -0.386). 6-8 weeks after discontinuation, former antagonist users showed similar BP ND to controls ( p > 0.25), whereas former partial agonist users had higher BP ND than controls ( p = 0.027, CI = 0.069 to 1.085). Participants who discontinued antagonists relapsed more often (81%) than those who discontinued partial agonists (17%)(χ 2 = 5.32, p = 0.021). CONCLUSIONS: Discontinuation of partial D 2R agonists may affect D 2/3R availability differently than discontinuation of antagonists, which might explain the greater relapse risk after tapering antagonists than partial agonist antipsychotics. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0033-2917; 1469-8978 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40916717; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/4d50a15f-b7d5-4a85-87e5-858e73fbd9af; info:eu-repo/semantics/altIdentifier/pissn/0033-2917; info:eu-repo/semantics/altIdentifier/eissn/1469-8978 |
| DOI: |
10.1017/S003329172510161X |
| Availability: |
https://hdl.handle.net/11370/4d50a15f-b7d5-4a85-87e5-858e73fbd9af; https://research.rug.nl/en/publications/4d50a15f-b7d5-4a85-87e5-858e73fbd9af; https://doi.org/10.1017/S003329172510161X; https://pure.rug.nl/ws/files/1405063980/dopamine-d23r-availability-after-discontinuation-of-antipsychotic-treatment-a-11craclopride-pet-study-in-remitted-first-episode-psychosis-patients.pdf |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.D1F4AEEF |
| Database: |
BASE |