Diagnostic Performance of Clinical and Routine Laboratory Data in Acute Mesenteric Arterial Occlusion : An International Multicenter Study
| Title: | Diagnostic Performance of Clinical and Routine Laboratory Data in Acute Mesenteric Arterial Occlusion : An International Multicenter Study |
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| Authors: | Soltanzadeh-Naderi, Yasmin; Reintam Blaser, Annika; Björck, Martin; Nuzzo, Alexandre; Starkopf, Joel; Forbes, Alastair; Murruste, Marko; Tamme, Kadri; Talving, Peep; Voomets, Anna-Liisa; Koitmäe, Merli; Bala, Miklosh; Bodnar, Zsolt; Casian, Dumitru; Demetrashvili, Zaza; D'Oria, Mario; Dúran Muñoz-Cruzado, Virginia; Fuglseth, Hanne; Hellerman Itzhaki, Moran; Hess, Benjamin; Kase, Karri; Lein, Kristoffer; Lindner, Matthias; Loudet, Cecilia I.; Mole, Damian J.; Saar, Sten; Scheiterle, Maximilian; Voon, Kenneth; Tverring, Jonas; Acosta, Stefan; Collaborators, AMESI Investigators |
| Publisher Information: | Uppsala universitet, Kärlkirurgi; Lund Univ, Dept Clin Sci, S-21428 Malmö, Sweden.; Univ Tartu, Inst Clin Med, EE-50090 Tartu, Estonia.;Lucerne Cantonal Hosp, Dept Intens Care Med, CH-6000 Luzern, Switzerland.; Univ Tartu, Inst Clin Med, EE-50090 Tartu, Estonia; Paris Cite Univ, Beaujon Hosp, Intestinal Stroke Ctr, Dept Gastroenterol,IBD & Intestinal Failure, F-75006 Paris, France.; Univ Tartu, Inst Clin Med, EE-50090 Tartu, Estonia.;Tartu Univ Hosp, EE-50406 Tartu, Estonia.; Univ Tartu, Inst Clin Med, EE-50090 Tartu, Estonia.; Univ Tartu, Inst Clin Med, EE-50090 Tartu, Estonia.;North Estonia Med Ctr, Div Acute Care Surg, EE-13419 Tallinn, Estonia.; Tartu Univ Hosp, EE-50406 Tartu, Estonia.; Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Univ Tartu, Inst Math & Stat, EE-50090 Tartu, Estonia.; Hebrew Univ Jerusalem, Fac Med, Hadassah Med Ctr, Jerusalem, Israel.; Letterkenny Univ Hosp, Letterkenny F92 AE81, Ireland.; Nicolae Testemitanu State Univ Med & Pharm Republ, Dept Gen Surg, MD-2004 Kishinev, Moldova.; N Kipshidze Cent Univ Hosp, Tbilisi 6160, Georgia.; Univ Trieste, Dept Clin Surg & Hlth Sci, Div Vasc & Endovasc Surg, Trieste, Italy.; Virgen Rocio Univ Hosp, Seville 41013, Spain.; Stavanger Univ Hosp, N-4011 Stavanger, Norway.; Tel Aviv Univ, Rabin Med Ctr, IL-4941492 Petah Tiqwa, Israel.; Lucerne Cantonal Hosp, Dept Intens Care Med, CH-6000 Luzern, Switzerland.; Univ Hosp North Norway, N-9019 Tromso, Norway.; Univ Klinikum Schleswig Holstein, Campus Kiel, D-24105 Kiel, Germany.; Hosp Gen San Martin La Plata, Buenos Aires, Argentina.; Royal Infirm Edinburgh NHS Trust, Edinburgh EH16 4SA, Scotland.; North Estonia Med Ctr, EE-13419 Tallinn, Estonia.; Azienda Osped Univ Careggi, I-50134 Florence, Italy.; Sarawak Gen Hosp, Kuching 93586, Malaysia.; Lund Univ, Dept Clin Sci, S-22100 Lund, Sweden. |
| Publication Year: | 2024 |
| Collection: | Uppsala University: Publications (DiVA) |
| Subject Terms: | acute mesenteric ischemia; arterial occlusive AMI; acute superior mesenteric artery; clinical diagnosis; laboratory markers; Cardiology and Cardiovascular Disease; Kardiologi och kardiovaskulära sjukdomar; Anesthesiology and Intensive Care; Anestesi och intensivvård |
| Description: | Background: There are no clinical or laboratory markers that can diagnose acute mesenteric ischemia (AMI) accurately. This study aimed to find differences in clinical and laboratory markers between arterial occlusive AMI and other acute abdominal diseases where AMI was initially suspected. Methods: This was a post hoc study of an international prospective multicenter study where data on patients with suspected AMI were collected. Independent factors associated with arterial occlusive AMI were evaluated in a multivariable logistic regression analysis. Results: The number of patients with arterial occlusive AMI was 231, consisting of thrombotic (n = 104), embolic (n = 61), and indeterminate (n = 66) occlusions. The non-AMI group included 287 patients, of whom 128 had strangulated bowel obstruction. Current smoking (odds ratio [OR] 2.56, 95% confidence interval [CI] 1.31–5.03), hypertension (OR 2.08, 95% CI 1.09–3.97), bowel emptying (OR 3.25, 95% CI 1.59–6.63), and leukocytosis (OR 1.54, 95% CI 1.14–2.08) at admission were independently associated with arterial occlusive AMI compared to the non-AMI group. Conclusions: This study found clinical and laboratory data to be associated with arterial occlusive AMI in patients with suspicion of AMI, which can possibly be of value in screening for arterial occlusive AMI at the emergency department. Further studies are needed to find more accurate diagnostic markers. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| Relation: | Diagnostics, 2075-4418, 2024, 14:23; PMID 39682613; ISI:001376950900001 |
| DOI: | 10.3390/diagnostics14232705 |
| Availability: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-546545; https://doi.org/10.3390/diagnostics14232705 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.D215F04C |
| Database: | BASE |