| Title: |
Long-term outcomes following Sacubitril/Valsartan therapy for chronic HFrEF. Italian Real-World Multicenter Study |
| Authors: |
Dattilo, Giuseppe; Licordari, Roberto; Imbalzano, Egidio; Cannata, Antonio; Agostoni, Piergiuseppe; Aimo, Alberto; Barillà, Francesca; Carluccio, Erberto; Ciccarelli, Michele; Di Bella, Gianluca; Dini, Frank L; Emdin, Michele; Loria, Francesco; Mapelli, Massimo; Mariano, Enrica; Niglio, Francesco Paolo; Palazzuoli, Alberto; Palmieri, Gianpaolo; Pavoncelli, Simona; Salvioni, Elisabetta; Savarese, Gianluigi; Correale, Michele |
| Contributors: |
G. Dattilo; R. Licordari; E. Imbalzano; A. Cannata; P. Agostoni; A. Aimo; F. Barillà; E. Carluccio; M. Ciccarelli; G. Di Bella; F.L. Dini; M. Emdin; F. Loria; M. Mapelli; E. Mariano; F.P. Niglio; A. Palazzuoli; G. Palmieri; S. Pavoncelli; E. Salvioni; G. Savarese; M. Correale |
| Publisher Information: |
Oxford Academic |
| Publication Year: |
2026 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
NT-proBNP; cardiac remodeling; global longitudinal strain; heart failure with reduced ejection fraction; real-world evidence; sacubitril/valsartan; Settore MEDS-07/B - Malattie dell'apparato cardiovascolare |
| Description: |
Background and aims: Long-term real-world effects of sacubitril/valsartan (S/V) and the impact of S/V dose reduction or discontinuation are less defined. We assessed longitudinal changes after S/V initiation and the association of dose changes with major adverse cardiovascular events (MACE). Methods: Multicenter retrospective study of 592 HFrEF outpatients starting S/V (83% men; age 68±10 years; LVEF 32±7%). NT-proBNP, Kansas City Cardiomyopathy Questionnaire (KCCQ) and echocardiography were collected at baseline, 12 months and last follow-up. MACE was analyzed with Kaplan-Meier and Cox models. Results: NT-proBNP decreased from 1,000 (494-2,333) to 751 (304-1,726) and 735 (215-1,980) pg/mL (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41843757; journal:ESC HEART FAILURE; https://hdl.handle.net/2434/1229456 |
| DOI: |
10.1093/eschf/xvag082 |
| Availability: |
https://hdl.handle.net/2434/1229456; https://doi.org/10.1093/eschf/xvag082 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.D2171F6A |
| Database: |
BASE |