| Title: |
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention |
| Authors: |
Wang, Z; Emmerich, A; Pillon, NJ; Moore, T; Hemerich, D; Cornelis, MC; Mazzaferro, E; Broos, S; Ahluwalia, TS; Bartz, TM; Bentley, AR; Bielak, LF; Chong, M; Chu, AY; Berry, D; Dorajoo, R; Dueker, ND; Kasbohm, E; Feenstra, B; Feitosa, MF; Gieger, C; Graff, M; Hall, LM; Haller, T; Hartwig, FP; Hillis, DA; Huikari, V; Heard-Costa, N; Holzapfel, C; Jackson, AU; Johansson, A; Jorgensen, AM; Kaakinen, MA; Karlsson, R; Kerr, KF; Kim, B; Koolhaas, CM; Kutalik, Z; Lagou, V; Lind, PA; Lorentzon, M; Lyytikainen, L-P; Mangino, M; Metzendorf, C; Monroe, KR; Pacolet, A; Perusse, L; Pool, R; Richmond, RC; Rivera, NV; Robiou-Du-Pont, S; Schraut, KE; Schulz, C-A; Stringham, HM; Tanaka, T; Teumer, A; Turman, C; Van der Most, PJ; Vanmunster, M; Van Rooij, FJA; Van Vliet-Ostaptchouk, JV; Zhang, X; Zhao, J-H; Zhao, W; Balkhiyarova, Z; Balslev-Harder, MN; Baumeister, SE; Beilby, J; Blangero, J; Boomsma, DI; Brage, S; Braund, PS; Brody, JA; Bruinenberg, M; Ekelund, U; Liu, C-T; Cole, JW; Collins, FS; Cupples, LA; Esko, T; Enroth, S; Faul, JD; Fernandez-Rhodes, L; Fohner, AE; Franco, OH; Galesloot, TE; Gordon, SD; Grarup, N; Hartman, CA; Heiss, G; Hui, J; Illig, T; Jago, R; James, A; Joshi, PK; Jung, T; Kahonen, M; Kilpelainen, TO; Koh, W-P; Kolcic, I; Kraft, PP; Kuusisto, J; Launer, LJ; Li, A; Linneberg, A; Luan, J; Vidal, PM; Medland, SE; Milaneschi, Y; Moscati, A; Musk, B; Nelson, CP; Nolte, IM; Pedersen, NL; Peters, A; Peyser, PA; Power, C; Raitakari, OT; Reedik, M; Reiner, AP; Ridker, PM; Rudan, I; Ryan, K; Sarzynski, MA; Scott, LJ; Scott, RA; Sidney, S; Siggeirsdottir, K; Smith, AV; Smith, JA; Sonestedt, E; Strom, M; Tai, ES; Teo, KK; Thorand, B; Toenjes, A; Tremblay, A; Uitterlinden, AG; Vangipurapu, J; Van Schoor, N; Volker, U; Willemsen, G; Williams, K; Wong, Q; Xu, H; Young, KL; Yuan, JM; Zillikens, MC; Zonderman, AB; Ameur, A; Bandinelli, S; Bis, JC; Boehnke, M; Bouchard, C; Chasman, DI; Smith, GD; De Geus, EJC; Deldicque, L; Dorr, M; Evans, MK; Ferrucci, L; Fornage, M; Fox, C; Garland, TJ; Gudnason, V; Gyllensten, U; Hansen, T; Hayward, C; Horta, BL; Hypponen, E; Jarvelin, M-R; Johnson, WC; Kardia, SLR; Kiemeney, LA; Laakso, M; Langenberg, C; Lehtimaki, T; Le Marchand, L; Magnusson, PKE; Martin, NG; Melbye, M; Metspalu, A; Meyre, D; North, KE; Ohlsson, C; Oldehinkel, AJ; Orho-Melander, M; Pare, G; Park, T; Pedersen, O; Penninx, BWJH; Pers, TH; Polasek, O; Prokopenko, I; Rotimi, CN; Samani, NJ; Sim, X; Snieder, H; Sorensen, TIA; Spector, TD; Timpson, NJ; Van Dam, RM; Van der Velde, N; Van Duijn, CM; Vollenweider, P; Volzke, H; Voortman, T; Waeber, G; Wareham, NJ; Weir, DR; Wichmann, H-E; Wilson, JF; Hevener, AL; Krook, A; Zierath, JR; Thomis, MAI; Loos, RJF; Den Hoed, M |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2022 |
| Collection: |
Queen Mary University of London: Queen Mary Research Online (QMRO) |
| Description: |
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention. |
| Document Type: |
article in journal/newspaper |
| File Description: |
1332 - + |
| Language: |
unknown |
| Relation: |
NATURE GENETICS; https://qmro.qmul.ac.uk/xmlui/handle/123456789/103566 |
| DOI: |
10.1038/s41588-022-01165-1 |
| Availability: |
https://qmro.qmul.ac.uk/xmlui/handle/123456789/103566; https://doi.org/10.1038/s41588-022-01165-1 |
| Rights: |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. ; © The Author(s) 2022 |
| Accession Number: |
edsbas.D21C06C2 |
| Database: |
BASE |