| Title: |
Effect of Continuous Positive Airway Pressure on C‐reactive Protein Levels in Sleep Apnea ; A Meta‐analysis |
| Authors: |
Friedman, Michael; Samuelson, Christian G.; Hamilton, Craig; Fisher, Michelle; Kelley, Kanwar; Joseph, Ninos J.; Wang, Pa‐Chun; Lin, Hsin‐Ching |
| Source: |
Otolaryngology–Head and Neck Surgery ; volume 147, issue 3, page 423-433 ; ISSN 0194-5998 1097-6817 |
| Publisher Information: |
Wiley |
| Publication Year: |
2012 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Objective Evaluate the effects of continuous positive airway pressure (CPAP) on C‐reactive protein (CRP) levels, reported either as a primary or secondary end point among patients with obstructive sleep apnea‐hypopnea syndrome (OSAHS) based on a meta‐analysis of published studies. Data Sources English‐language searches of PubMed, Ovid, and the Cochrane databases were completed. Reference sections of identified studies were also examined for additional relevant articles to review. Review Methods Studies of adult patients with OSAHS who reported pre‐ and post‐CPAP treatment CRP were reviewed and analyzed. Two independent reviewers extracted data from 10 peer‐reviewed studies, which were combined using a random effects meta‐analysis model. Results The CPAP treatment was found to lead to a significant reduction in CRP levels (17.8%, P =. 002). This corresponds to an effect size of −0.485 (−0.731, −0.240). Sensitivity analysis was done to determine the impact of study design. Both case‐control studies and case‐series studies yielded a significant effect. Sensitivity analysis also yielded a significant effect for studies with average body mass index |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1177/0194599812451840 |
| Availability: |
http://dx.doi.org/10.1177/0194599812451840; https://onlinelibrary.wiley.com/doi/pdf/10.1177/0194599812451840; https://onlinelibrary.wiley.com/doi/full-xml/10.1177/0194599812451840 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.D289405 |
| Database: |
BASE |