Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
| Title: | Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution |
|---|---|
| Authors: | Justice, Anne E; Karaderi, Tugce; Highland, Heather M; Young, Kristin L; Graff, Mariaelisa; Lu, Yingchang; Turcot, Valérie; Auer, Paul L; Fine, Rebecca S; Guo, Xiuqing; Schurmann, Claudia; Lempradl, Adelheid; Marouli, Eirini; Mahajan, Anubha; Winkler, Thomas W; Locke, Adam E; Medina-Gomez, Carolina; Esko, Tõnu; Vedantam, Sailaja; Giri, Ayush; Lo, Ken Sin; Alfred, Tamuno; Mudgal, Poorva; Ng, Maggie C Y; Heard-Costa, Nancy L; Feitosa, Mary F; Manning, Alisa K; Willems, Sara M; Sivapalaratnam, Suthesh; Abecasis, Goncalo; Alam, Dewan S; Allison, Matthew; Amouyel, Philippe; Arzumanyan, Zorayr; Balkau, Beverley; Bastarache, Lisa; Bergmann, Sven; Bielak, Lawrence F; Broer, Linda; Chowdhury, Rajiv; Cox, Amanda J; Hansen, Torben; Perry, John R B; Teumer, Alexander; Uitterlinden, André G; van Duijn, Cornelia M; Zhao, Jing Hua; Zhao, Wei; Zillikens, M Carola; Rivadeneira, Fernando; North, Kari E.; Lindgren, Cecilia M. |
| Source: | CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetics Consortium, GoT2D Genes Consortium, The InterAct consortium, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Justice, A E, Karaderi, T, Highland, H M, Young, K L, Graff, M, Lu, Y, Turcot, V, Auer, P L, Fine, R S, Guo, X, Schurmann, C, Lempradl, A, Marouli, E, Mahajan, A, Winkler, T W, Locke, A E, Medina-Gomez, C, Esko, T, Vedantam, S, Giri, A, Lo, K S, Alfred, T, Mudgal, P, Ng, M C Y, Heard-Costa, N L, Feitosa, M F, .... |
| Publication Year: | 2019 |
| Subject Terms: | /dk/atira/pure/keywords/researchprograms/AFL001000/EMCMM013902; name=EMC MM-01-39-02; /dk/atira/pure/keywords/researchprograms/AFL001000/EMCMM013909A; name=EMC MM-01-39-09-A; /dk/atira/pure/keywords/researchprograms/AFL001000/EMCNIHES016402; name=EMC NIHES-01-64-02; /dk/atira/pure/keywords/researchprograms/AFL001000/EMCNIHES033002; name=EMC NIHES-03-30-02 |
| Description: | Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1061-4036; 1546-1718 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/30778226; info:eu-repo/semantics/altIdentifier/pissn/1061-4036; info:eu-repo/semantics/altIdentifier/eissn/1546-1718 |
| DOI: | 10.1038/s41588-018-0334-2 |
| Availability: | https://pure.eur.nl/en/publications/a6a9cdb9-efbb-43bc-aca2-cfd1a11e9a1f; https://doi.org/10.1038/s41588-018-0334-2; https://pure.eur.nl/ws/files/48171342/Repub-115517.pdf; https://hdl.handle.net/1765/115517 |
| Rights: | info:eu-repo/semantics/openAccess ; https://www.eur.nl/en/library/media/2024-12-researchoutputsundertaverne-backgroundandtermsofusev2 |
| Accession Number: | edsbas.D2970A70 |
| Database: | BASE |