| Title: |
Impact of Red Blood Cell Transfusion on In-hospital Mortality of Isolated Coronary Artery Bypass Graft Surgery |
| Authors: |
Colson, Pascal; Gaudard, Philippe; Meunier, Charles; Seguret, Fabienne |
| Contributors: |
Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Institut de Génomique Fonctionnelle (IGF); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM); Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp) |
| Source: |
ISSN: 0003-4932. |
| Publisher Information: |
CCSD; Lippincott, Williams & Wilkins |
| Publication Year: |
2023 |
| Collection: |
Université de Montpellier: HAL |
| Subject Terms: |
CABG surgery; Transfusion; Mortality; MESH: Adult; MESH: Aged; MESH: Blood Transfusion; MESH: Coronary Artery Bypass; MESH: Erythrocyte Transfusion; MESH: Female; MESH: Hospital Mortality; MESH: Humans; MESH: Male; MESH: Retrospective Studies; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| Description: |
International audience ; Objective: To assess the relationship between red blood cell (RBC) transfusion exposure and in-hospital mortality after isolated coronary artery bypass graft (CABG) surgery.Background: RBC transfusion was commonly used to treat anemia in isolated CABG surgery, but transfusion was found an independent risk factor of postoperative mortality; recent guidelines on patient blood management strategy issued in the last decade may have changed transfusion incidence and related mortality.Methods: A retrospective cohort study was conducted from the National database on patients' hospital discharge reports. Consecutive adult patients who underwent isolated CABG surgery in France from January 1, 2016, to December 31, 2018, were included. The primary outcome was the in-hospital mortality rate. RBC transfusion during the hospital stay was identified by specific codes and ordered as categorical variables (no, moderate, or massive transfusion).Results: A total of 37,498 participants were studied [mean (SD) age, 66.5 (9.6) years, 31,587 (84.2%) were men]. In-hospital mortality rate was 1.45% (n=541) and RBC transfusion rate was 9.4% (n=3521). In-hospital deaths were more frequent among transfused patients [1.06% (361) if no transfusion up to 10.2% (n=113) if massive transfusion]. After adjustment for confounding variables, RBC transfusion remained a significant independent factor of in-hospital mortality: odds ratio=1.66 (95% confidence interval: 1.27-2.19, P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35762599; PUBMED: 35762599; WOS: 001004331100047 |
| DOI: |
10.1097/SLA.0000000000005488 |
| Availability: |
https://hal.science/hal-03708326; https://hal.science/hal-03708326v1/document; https://hal.science/hal-03708326v1/file/2022%20Colson%20et%20al.,%20Impact%20of%20Red.pdf; https://doi.org/10.1097/SLA.0000000000005488 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.D31525EF |
| Database: |
BASE |