Sex Differences in the Genetic Causes of Dilated Cardiomyopathy
| Title: | Sex Differences in the Genetic Causes of Dilated Cardiomyopathy |
|---|---|
| Authors: | M Mangino; KA McGurk; P Theotokis; RJ Buchan; CR Stockwell; PK Thami; E Jennings; E Wan; C Enright; A Adlan; T Akbari; J Baksi; PJR Barton; C Berry; G Carr-White; A Chiribiri; R Cooper; A Dattani; AS Flett; RS Gardner; JP Greenwood; BP Halliday; DJ Hammersley; DC Hutchings; M Mahmod; B Marrow; Gerald McCann; M Motwani; S Neubauer; DP O’ Regan; SP Page; A Pantazis; C Peebles; B Raman; PP Swoboda; A Varnava; L Venetucci; H Watkins; D Wright; SK Prasad; SA Cook; JS Ware; U Tayal |
| Publication Year: | 2025 |
| Collection: | University of Leicester: Figshare |
| Subject Terms: | Cardiovascular medicine and haematology; Health sciences; GO-DCM Investigators |
| Description: | Dilated cardiomyopathy (DCM) has a monogenic aetiology in up to a third of cases1. It appears to affect twice as many males compared to females. This sex difference is observed in both monogenic autosomal cases and DCM without an identified monogenic cause. This could be due to ascertainment bias, e.g. differences in diagnostic criteria, or sex differences in disease susceptibility, with males at risk or females protected. It is not known whether specific genetic subtypes manifest sex-differences in penetrance. We have extensively characterised the genetic architecture of DCM2, 3. In this study we investigated whether there are sex differences in the underlying genetic architecture of DCM, indicating gene-specific influences of sex on disease susceptibility. |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| Relation: | 2381/30344239.v1; https://figshare.com/articles/journal_contribution/Sex_Differences_in_the_Genetic_Causes_of_Dilated_Cardiomyopathy/30344239 |
| Availability: | https://figshare.com/articles/journal_contribution/Sex_Differences_in_the_Genetic_Causes_of_Dilated_Cardiomyopathy/30344239 |
| Rights: | CC BY 4.0 |
| Accession Number: | edsbas.D3443FDD |
| Database: | BASE |