| Title: |
Circulating memory is sufficient for protection against Chlamydia muridarum in the murine female reproductive tract |
| Authors: |
Labuda, Jasmine C; Pham, Oanh; McSorley, Stephen J |
| Source: |
The Journal of Immunology ; volume 200, issue Supplement_1, page 117.7-117.7 ; ISSN 0022-1767 1550-6606 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2018 |
| Description: |
Chlamydia trachomatis is the most prevalent bacterial STI worldwide and yet no vaccine currently exists to protect the public from this reproductive tract pathogen. Recent studies show that Tissue Resident Memory T cells (Trm) are essential for vaccine-induced protection against Chlamydia trachomatis in mice. Moreover, Trm have been implicated in protective immunity to other reproductive tract pathogens including Herpes Simplex Virus. Here, we examine the requirement of Trm T cells in protection against the murine pathogen Chlamydia muridarum (Cm), commonly used to model human Chlamydia infection. Using parabiosis to test whether circulating memory from mice immune to Cm infection can protect naïve mice from reproductive tract challenge with Cm, we found that naïve mice receiving circulating immunity were fully protected from Cm challenge. Ongoing studies with MHC class-II tetramers will examine the phenotype of protective circulating Chlamydia-specific CD4 memory T cells and whether migration to the reproductive tract is a requirement for protection against secondary challenge. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.4049/jimmunol.200.supp.117.7 |
| Availability: |
https://doi.org/10.4049/jimmunol.200.supp.117.7; https://academic.oup.com/jimmunol/article/200/Supplement_1/117.7/7976216 |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.D36A0AFE |
| Database: |
BASE |