| Title: |
Differential Effects of Adiposity and Childhood Growth Trajectories on Retinal Microvascular Architecture |
| Authors: |
Tapp, Robyn J; Ness, Andy R; Williams, Cathy; Howe, Laura D; Tilling, Kate; Witt, Nicholas; Chaturvedi, Nish; McG Thom, Simon A; Hughes, Alun D. |
| Source: |
Tapp, R J, Ness, A R, Williams, C, Howe, L D, Tilling, K, Witt, N, Chaturvedi, N, McG Thom, S A & Hughes, A D 2013, 'Differential Effects of Adiposity and Childhood Growth Trajectories on Retinal Microvascular Architecture', Microcirculation, vol. ePub ahead of print. https://doi.org/10.1111/micc.12060 |
| Publication Year: |
2013 |
| Collection: |
University of Bristol: Bristol Reserach |
| Description: |
OBJECTIVES: We hypothesised that trajectories of adiposity across childhood would be associated with retinal microcirculatory diameters at age 12 years, independent of blood pressure (BP). METHODS: The Avon Longitudinal Study of Parents and Children followed a cohort of children born in 1991-1992. The current study includes all children with retinal images acquired at the 12 year clinic and individual trajectories of ponderal index (PI) from 0-2 years and body mass index (BMI) from 2-10 years. Retinal microvascular measures included retinal arteriolar and venular diameters. RESULTS: Children in this analysis had a birth weight of 3.5 ± 0.4 kg, a PI of 26.2 ± 2.4 kg/m(3) and a gestational age of 39.7 ± 1.4 weeks (mean ± standard deviation (SD)). Analysis of growth trajectories showed that lower PI at birth was associated with narrower retinal arterioles. Higher PI at birth was associated with wider venular diameter, and a stronger positive association was evident between BMI change at 5-5.5 and 8.5-10 years with wider venular diameters. Current fat mass was also associated with wider venular diameters. CONCLUSIONS: Retinal arterioles and venules are differentially associated with growth in early life and childhood adiposity. Early adiposity may adversely affect the microcirculation, with important implications for cardiovascular risk in adulthood. © 2013 John Wiley & Sons Ltd. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/23517335; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/1983/afbf24e5-82cd-4737-ab5d-5f69fac3a299 |
| DOI: |
10.1111/micc.12060 |
| Availability: |
https://hdl.handle.net/1983/afbf24e5-82cd-4737-ab5d-5f69fac3a299; https://research-information.bris.ac.uk/en/publications/afbf24e5-82cd-4737-ab5d-5f69fac3a299; https://doi.org/10.1111/micc.12060 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| Accession Number: |
edsbas.D37F15BA |
| Database: |
BASE |