| Title: |
Frequency and characterization of cognitive impairments in patients diagnosed with paediatric central nervous system tumours: a systematic review |
| Authors: |
Francesco Sciancalepore; Francesco Fabozzi; Giulia Albino; Giada Del Baldo; Valentina Di Ruscio; Beatrice Laus; Danilo Menegatti; Roberto Premuselli; Domitilla Elena Secco; Alberto Eugenio Tozzi; Eleonora Lacorte; Nicola Vanacore; Andrea Carai; Angela Mastronuzzi |
| Contributors: |
Sciancalepore, Francesco; Fabozzi, Francesco; Albino, Giulia; DEL BALDO, Giada; DI RUSCIO, Valentina; Laus, Beatrice; Menegatti, Danilo; Premuselli, Roberto; Elena Secco, Domitilla; Eugenio Tozzi, Alberto; Lacorte, Eleonora; Vanacore, Nicola; Carai, Andrea; Mastronuzzi, Angela |
| Publication Year: |
2023 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
brain tumour; central nervous system; cognitive deficit; neuropsychology; paediatric oncology |
| Description: |
Background: This systematic review has been conducted with the aim of characterizing cognitive deficits and analyzing their frequency in survivors of paediatric Central Nervous System tumours. Materials and methods: All literature published up to January 2023 was retrieved searching the databases "PubMed", "Cochrane", "APA PsycInfo" and "CINAHL". The following set of pre-defined inclusion criteria were then individually applied to the selected articles in their full-text version: i) Retrospective/prospective longitudinal observational studies including only patients diagnosed with primary cerebral tumours at ≤ 21 years (range 0-21); ii) Studies including patients evaluated for neuro-cognitive and neuro-psychological deficits from their diagnosis and/or from anti-tumoral therapies; iii) Studies reporting standardized tests evaluating patients' neuro-cognitive and neuro-psychological performances; iv) Patients with follow-ups ≥ 2 years from the end of their anti-tumoral therapies; v) Studies reporting frequencies of cognitive deficits. Results: 39 studies were included in the analysis. Of these, 35 assessed intellectual functioning, 30 examined memory domains, 24 assessed executive functions, 22 assessed attention, 16 examined visuo-spatial skills, and 15 explored language. A total of 34 studies assessed more than one cognitive function, only 5 studies limited their analysis on a single cognitive domain. Attention impairments were the most recurrent in this population, with a mean frequency of 52.3% after a median period post-treatment of 11.5 years. The other cognitive functions investigated in the studies showed a similar frequency of impairments, with executive functions, language, visuospatial skills and memory deficits occurring in about 40% of survivors after a similar post-treatment period. Longitudinal studies included in the systematic review showed a frequent decline over time of intellectual functioning. Conclusions: Survivors of paediatric Central Nervous System tumours experience cognitive sequelae ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37274224; info:eu-repo/semantics/altIdentifier/wos/WOS:000999604200001; journal:FRONTIERS IN ONCOLOGY; https://hdl.handle.net/11573/1686290 |
| Availability: |
https://hdl.handle.net/11573/1686290 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.D3885B07 |
| Database: |
BASE |