| Title: |
The Physiological Association between Obstructive Sleep Apnea and Alzheimer's Disease |
| Authors: |
Dakterzada, Farida; Montero-Castilla, Nathalia; Carnes Vendrell, Anna; Piñol Ripoll, Gerard |
| Publisher Information: |
Springer |
| Publication Year: |
2025 |
| Collection: |
Universitat de Lleida: Repositori Obert UdL |
| Subject Terms: |
Life Sciences & Biomedicine; Obstructive Sleep Apnea; Alzheimer’s Disease; Intermittent Hypoxia; Sleep Fragmentation; Cerebrovascular Dysfunction; Memory Consolidation |
| Description: |
Purpose of Review Alzheimer’s disease (AD) is multifactorial, and it is believed that several factors, including genetic, metabolic, bioenergetics, and environmental factors, have a role in the onset and development of this disease. Obstructive sleep apnea (OSA) has a high prevalence in patients with AD and is considered a risk factor for the development of AD. Besides, several features, including shared comorbidities, the induction of cognitive impairment and neurodegeneration make both pathologies highly interconnected. We reviewed the existing knowledge about the possible OSA-induced brain alterations that can potentially participate in the development and progression of AD. Recent Findings Intermittent hypoxia and sleep fragmentation have been considered as the most important OSA-induced alterations that can trigger dysregulation of multiple pathways at the cerebral tissue. Although both events can act synergistically, here we discussed the possible role of each event in development and progression of AD individually. Intermittent hypoxia has been linked to increased oxidative stress, systemic and neuroinflammation, and consequently cerebrovascular dysfunctionality. On the other hand, sleep fragmentation and deprivation can challenge memory consolidation and the brain clearance. Summary OSA-induced pathophysiological alterations in AD patients can lead to synaptic damage, neurodegeneration and increased AD-related brain pathology that will manifest by progressive cognitive impairment in this disease. ; Funding Open Access funding provided thanks to the CRUECSIC agreement with Springer Nature. GPR received funding from Diputació de Lleida (PP10605-PIRS2021), Instituto de Salud Carlos III and was cofunded by the European Union (ERDF/ESF, “Investing in your future” and “A way to build Europe”) (PI22/01687), and the Agency for the Management of University and Research Grants (2021SGR00761). FD is an IRBLleida IREP-2023 postdoctoral Fellow. IRBLleida is a CERCA Programme of the Government of Catalonia. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Reproducció del document publicat a: https://doi.org/10.1007/s40675-025-00340-0; Current Sleep Medicine Reports, 2025, vol. 11, núm. 1, article number 27; https://hdl.handle.net/10459.1/468996 |
| DOI: |
10.1007/s40675-025-00340-0 |
| Availability: |
https://hdl.handle.net/10459.1/468996; https://doi.org/10.1007/s40675-025-00340-0 |
| Rights: |
cc-by (c)The Authors, 2025 ; Attribution 4.0 International ; info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.D4327F6C |
| Database: |
BASE |