| Title: |
High-Risk Histopathological Features of Retinoblastoma following Primary Enucleation: A Global Study of 1426 Patients from 5 Continents |
| Authors: |
Kaliki, Swathi; Vempuluru, Vijitha S; Bakal, Komal Rajendra; Dorji, Samten; Tanna, Vishakha; Shields, Charlotte N; Fallon, Samuel J; Raval, Vishal; Ahmad, Alia; Mushtaq, Asma; Hussain, Mahvish; Yousef, Yacoub A; Mohammad, Mona; Roy, Soma Rani; Huque, Fahmida; Tatiana, Ushakova; Yuri, Serov; Vladimir, Polyakov; Zambrano, Sandro Casavilca; Alarcón-León, Sandra; Valdiviezo-Zapata, Cinthya; Vargas-Martorellet, Maria; Gutierrez-Chira, Cynthia; Buitrago, Mario; Ortiz, Joana Sánchez; Diaz-Coronado, Rosdali; Tripathy, Devjyoti; Rath, Suryasnata; Patil, Gaurav; Berry, Jesse L; Pike, Sarah; Brown, Brianne; Tanabe, Mika; Frenkel, Shahar; Eiger-Moscovich, Maya; Pe'er, Jacob; Shields, Carol L; Eagle, Ralph C; Laiton, Andrea; Velasco, Ana Maria; Vega, Katherine; DeSimone, Joseph; Bejjanki, Kavya Madhuri; Kapoor, Anasua Ganguly; Venkataraman, Anusha; Bryant, Victoria; Reddy, M Ashwin; Sagoo, Mandeep S; Hubbard, G Baker; Azarcon, Corrina P; Olson, Thomas A; Grossniklaus, Hans; Rolfe, Olivia; Staffieri, Sandra E; O'Day, Roderick; Mathew, Anu A; Elder, James E; McKenzie, John D; Fabian, Ido Didi; Shemesh, Rachel; Vishnevskia-Dai, Vicktoria; Ali, Mohammed Hasnat; Jakati, Saumya; Mishra, Dilip K; Reddy Palkonda, Vijay Anand |
| Source: |
Retina (2024) (In press). |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2024 |
| Collection: |
University College London: UCL Discovery |
| Description: |
Purpose: To evaluate high-risk histopathological features (HRHF) following primary enucleation of eyes with retinoblastoma (RB) and assess the patient outcomes across continents // Methods: Retrospective study of 1426 primarily enucleated RB eyes from five continents // Results: Of all, 923 (65%) were from Asia (AS), 27 (2%) from Australia (AUS), 120 (8%) from Europe (EUR), 162 (11%) from North America (NA), and 194 (14%) from South America (SA). Based on the continent (AS vs. AUS vs. EUR vs. NA vs. SA), the histopathology features included massive choroidal invasion (31% vs. 7% vs. 13% vs. 19% vs. 27%, p=0.001), post-laminar optic nerve invasion (27% vs. 0% vs. 16% vs. 21% vs. 19%, p=0.0006), scleral infiltration (5% vs. 0% vs. 4% vs. 2% vs. 7%, p=0.13), and microscopic extrascleral infiltration (4% vs. 0% vs. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10196015/1/high_risk_histopathological_features_of.775.pdf; https://discovery.ucl.ac.uk/id/eprint/10196015/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10196015/1/high_risk_histopathological_features_of.775.pdf; https://discovery.ucl.ac.uk/id/eprint/10196015/ |
| Rights: |
open |
| Accession Number: |
edsbas.D48B9C6D |
| Database: |
BASE |