| Title: |
Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry. |
| Authors: |
Scelo, G; Torres-Duque, CA; Maspero, J; Tran, TN; Murray, R; Martin, N; Menzies-Gow, AN; Hew, M; Peters, MJ; Gibson, PG; Christoff, GC; Popov, TA; Côté, A; Bergeron, C; Dorscheid, D; FitzGerald, JM; Chapman, KR; Boulet, LP; Bhutani, M; Sadatsafavi, M; Jiménez-Maldonado, L; Duran-Silva, M; Rodriguez, B; Celis-Preciado, CA; Cano-Rosales, DJ; Solarte, I; Fernandez-Sanchez, MJ; Parada-Tovar, P; Bülow, AV; Bjerrum, AS; Ulrik, CS; Assing, KD; Rasmussen, LM; Hansen, S; Altraja, A; Bourdin, A; Taille, C; Charriot, J; Roche, N; Papaioannou, AI; Kostikas, K; Papadopoulos, NG; Salvi, S; Long, D; Mitchell, PD; Costello, R; Sirena, C; Cardini, C; Heffler, E; Puggioni, F; Canonica, GW; Guida, G; Iwanaga, T; Al-Ahmad, M; Linnemann, DL; García, U; Kuna, P; Fonseca, JA; Al-Lehebi, R; Koh Siyue, M; Rhee, CK; Cosio, BG; de Llano, LP; Perng Steve, D-W; Huang, EW-C; Wang, H-C; Tsai, M-J; Mahboub, B; Jaber Salameh, LI; Jackson, D; Busby, J; Heaney, LG; Pfeffer, P; Goddard, AG; Wang, E; Hoyte, F; Wechsler, ME; Chapman, N; Katial, R; Carter, V; Bulathsinhala, L; Eleangovan, N; Ariti, C; Lyu, J; Price, D; Porsbjerg, C |
| Publication Year: |
2023 |
| Collection: |
Queen Mary University of London: Queen Mary Research Online (QMRO) |
| Subject Terms: |
allergic rhinitis; anxiety/depression; chronic obstructive pulmonary disease; chronic rhinosinusitis; diabetes; dyslipidemia; gastroesophageal reflux disease; hypertension; nasal polys; obesity; osteoporosis; sleep apnea |
| Description: |
BACKGROUND: Investigation for the presence of asthma comorbidities is recommended by GINA as their presence can complicate asthma management. OBJECTIVE: To understand the prevalence and pattern of comorbidities and multimorbidity in adults with severe asthma and their association with asthma-related outcomes. METHODS: This was a cross-sectional study using data from the International Severe Asthma Registry from 22 countries. Thirty comorbidities were identified and categorized a priori as either (1) potentially T2-related, (2) potentially oral corticosteroid (OCS)-related or (3) mimicking/aggravating asthma. The association between comorbidities and asthma-related outcomes was investigated using multivariable models adjusted for country, age at enrollment, and sex. RESULTS: Of 11,821 patients, 69%, 67%, and 55% had ≥1 potentially T2-related, potentially OCS-related, or mimicking/aggravating comorbidities, respectively; 57% had ≥3 comorbidities, and 33% had comorbidities in all three categories. Patients with allergic rhinitis (AR), nasal polyposis (NP), and chronic rhinosinusitis (CRS) experienced 1.12- (p=0.003), 1.16- (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Ann Allergy Asthma Immunol; https://qmro.qmul.ac.uk/xmlui/handle/123456789/90715 |
| DOI: |
10.1016/j.anai.2023.08.021 |
| Availability: |
https://qmro.qmul.ac.uk/xmlui/handle/123456789/90715; https://doi.org/10.1016/j.anai.2023.08.021 |
| Rights: |
Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/us/ |
| Accession Number: |
edsbas.D4F53895 |
| Database: |
BASE |