| Title: |
Diminished Mycobacterium tuberculosis–specific T-cell Responses During Pregnancy in Women With HIV and Receiving Isoniazid Preventive Therapy |
| Authors: |
Saha, Aparajita; Escudero, Jaclyn N; Layouni, Troy; Mecha, Jerphason; Maleche-Obimbo, Elizabeth; Matemo, Daniel; Kinuthia, John; John-Stewart, Grace; Richardson, Barbra A; LaCourse, Sylvia M; Shah, Javeed A |
| Contributors: |
Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; NIH |
| Source: |
Open Forum Infectious Diseases ; volume 12, issue 2 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
Background Pregnancy increases Mycobacterium tuberculosis (Mtb) reactivation risk and alters immune responses. We assessed Mtb-specific CD4+ T-cell responses in pregnant women with HIV (WLHIV) and without, including those receiving isoniazid preventive therapy (IPT). Methods We measured adaptive immune responses from 33 participants (HIV+ 21, HIV− 12) with positive interferon-gamma release assay during pregnancy (20–34 weeks’ gestation), 6 weeks, and 12 months postpartum by intracellular cytokine staining. We measured overall responses using COMPASS and made comparisons by nonparametric analysis of variance. Result We observed diminished Mtb-specific CD4+ T-cell responses in WLHIV during pregnancy versus 12 months postpartum (COMPASS median functional score [FS] .009 vs 0.12, P = .03). WLHIV who received IPT (n = 8) during concurrent pregnancy had attenuated Mtb-specific CD4+ T-cell responses during pregnancy versus 12 months postpartum (median FS 8.3 × 10−7 vs 0.13, P = .02), but WLHIV who did not receive IPT during pregnancy had similar responses in pregnancy and postpartum. Mtb-specific CD8+ FS was increased postpartum in all groups. We found preexisting Mtb-specific CD4+ T-cell responses in participants who converted interferon-gamma release assay tests postpartum (n = 10). Conclusions Pregnant WLHIV, especially those on IPT, showed reduced Mtb-specific CD4+ T-cell responses. Understanding the impact of pregnancy on Mtb-specific T-cell responses may improve diagnostic approaches. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofaf067 |
| DOI: |
10.1093/ofid/ofaf067/61770419/ofaf067.pdf |
| Availability: |
https://doi.org/10.1093/ofid/ofaf067; https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaf067/61770419/ofaf067.pdf; https://academic.oup.com/ofid/article-pdf/12/2/ofaf067/61770419/ofaf067.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.D4FDCAC1 |
| Database: |
BASE |