| Title: |
EFFETTI DELL’AMINOFILLINA SUL RITORNO DELLA COSCIENZA, TEMPO DI BURST SUPPRESSION E CONCENTRAZIONE STIMATA DI PROPOFOL DURANTE L'ANESTESIA TOTALE ENDOVENOSA CON INFUSIONE CONTROLLATA A TARGET: UNO STUDIO OSSERVAZIONALE SU 54 PAZIENTI |
| Authors: |
LINASSI, FEDERICO |
| Contributors: |
Linassi, Federico; CARRON, MICHELE |
| Publisher Information: |
Università degli studi di Padova |
| Publication Year: |
2025 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
Settore MED/41 - Anestesiologia |
| Description: |
Aminophylline reverses the effects of propofol, and shortens the recovery time from general anesthesia by increasing the neuronal excitability. However, the aminophylline effects during total intravenous anesthesia (TIVA) with target-controlled infusion (TCI) have not been described yet. We compared: (a) the timing from (i) the end of propofol infusion until the return of eye-opening (REO) and the timing from (ii) the end of propofol infusion until the return of responsiveness (RoR) with or without an aminophylline bolus (4 mg kg-1) administered at the end of surgery, and (b) the timing from (iii) the start to the end of a Burst Suppression (BSupp) episode with or without an aminophylline bolus (4 mg kg-1) administered at BSupp emergence. Bispectral Index (BIS) values and the propofol effect-site concentration (CeP) delivered with TIVA-TCI at the 3 time points were also considered. This prospective observational study was approved by the Ethical Committee of Treviso Regional Hospital, Italy (N. 681/CE Marca), and registered with ClinicalTrials.gov (NCT06098196 for the RoR protocol and NCT06134037 for the BSupp protocol). All procedures in the study were in accordance with the ethical standards of our institutional and/or national research committees, as well as the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. We recruited 54 female patients scheduled for breast surgery with propofol (Eleveld PK/PD model) and remifentanil (Eleveld PK/PD model) TIVA-TCI. The patient assignment to deliver an aminophylline bolus was by chance, independently of patient scheduling, based on alternation between aminophylline users within the framework of a daily rotation 6-hour shift of the anesthesiologists involved in the study. The student-t test was used to compare continuous variables between the aminophylline and not-aminophylline groups. Categorical data were compared using a χ2 test. Statistical significance was set at p-values |
| Document Type: |
doctoral or postdoctoral thesis |
| Language: |
English |
| Relation: |
https://hdl.handle.net/11577/3549800 |
| Availability: |
https://hdl.handle.net/11577/3549800 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.D54590FE |
| Database: |
BASE |