| Title: |
Human Forebrain Organoid-Derived Extracellular Vesicle Labeling with Iron Oxides for In Vitro Magnetic Resonance Imaging |
| Authors: |
Liu, Chang; Helsper, Shannon; Marzano, Mark; Chen, Xingchi; Muok, Laureana; Esmonde, Colin; Zeng, Changchun; Sun, Li; Grant, Samuel C.; Li, Yan |
| Source: |
ISSN:2227-9059 ; Biomedicines, vol. 10 (12), Art.No. ARTN 3060. |
| Publisher Information: |
MDPI |
| Publication Year: |
2022 |
| Subject Terms: |
AGENTS; Biochemistry & Molecular Biology; CATENIN; CONTRAST; DELIVERY; EXOSOMES; extracellular vesicles; forebrain organoids; human pluripotent stem cells; Life Sciences & Biomedicine; magnetic resonance imaging; Medicine; Research & Experimental; MESENCHYMAL STEM-CELLS; NANOPARTICLES; nanoscale iron oxides; Pharmacology & Pharmacy; PROLIFERATION; Research & Experimental Medicine; Science & Technology; THERAPY; 3101 Biochemistry and cell biology; 3214 Pharmacology and pharmaceutical sciences; 3404 Medicinal and biomolecular chemistry |
| Description: |
The significant roles of extracellular vesicles (EVs) as intracellular mediators, disease biomarkers, and therapeutic agents, make them a scientific hotspot. In particular, EVs secreted by human stem cells show significance in treating neurological disorders, such as Alzheimer’s disease and ischemic stroke. However, the clinical applications of EVs are limited due to their poor targeting capabilities and low therapeutic efficacies after intravenous administration. Superparamagnetic iron oxide (SPIO) nanoparticles are biocompatible and have been shown to improve the targeting ability of EVs. In particular, ultrasmall SPIO (USPIO, |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://lirias.kuleuven.be/handle/20.500.12942/712535; https://doi.org/10.3390/biomedicines10123060; https://pubmed.ncbi.nlm.nih.gov/36551816 |
| DOI: |
10.3390/biomedicines10123060 |
| Availability: |
https://lirias.kuleuven.be/handle/20.500.12942/712535; https://hdl.handle.net/20.500.12942/712535; https://lirias.kuleuven.be/retrieve/89f79471-bf65-4f6f-8111-95dea9cc94ec; https://doi.org/10.3390/biomedicines10123060; https://pubmed.ncbi.nlm.nih.gov/36551816 |
| Rights: |
info:eu-repo/semantics/openAccess ; public ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.D5846EB8 |
| Database: |
BASE |