| Title: |
Incidence of diabetes in HIV-infected patients treated with first-line integrase strand transfer inhibitors: a French multicentre retrospective study |
| Authors: |
Ursenbach, Axel; Max, Vincent; Maurel, Marine; Bani-Sadr, Firouzé; Gagneux-Brunon, Amandine; Garraffo, Rodolphe; Ravaux, Isabelle; Robineau, Olivier; Makinson, Alain; Rey, David; Drobacheff-Thiébaut, C; Foltzer, A; Bouiller, K; Hustache-Mathieu, L; Chirouze, C; Lepiller, Q; Bozon, F; Babre, O; Brunel, A; Muret, P; Laurichesse, H; Lesens, O; Vidal, M; Mrozek, N; Aumeran, C; Baud, O; Corbin, V; Letertre-Gibert, P; Casanova, S; Prouteau, J; Jacomet, C; Lamaury, I; Fabre, I; Curlier, E; Ouissa, R; Herrmann-Storck, C; Tressieres, B; Bonijoly, T; Receveur, M; Boulard, F; Daniel, C; Clavel, C; Merrien, D; Perré, P; Guimard, T; Bollangier, O; Leautez, S; Morrier, M; Laine, L; Ader, F; Becker, A; Biron, F; Boibieux, A; Cotte, L; Ferry, T; Miailhes, P; Perpoint, T; Roux, Stéphane; Triffault-Fillit, C; Degroodt, S; Brochier, C; Valour, F; Chidiac, C; Ménard, A; Belkhir, A; Colson, P; Dhiver, C; Madrid, A; Martin-Degiovani, M; Meddeb, L; Mokhtari, M; Motte, A; Raoux, A; Tamalet, C; Toméi, C; Dupont, H Tissot; Brégigeon, S; Zaegel-Faucher, O; Obry-Roguet, V; Laroche, H; Orticoni, M; Soavi, M; de Lamarlière, P Geneau; Ressiot, E; Ducassou, M; Jaquet, I; Galie, S; Galinier, A; Martinet, P; Landon, M; Ritleng, A; Ivanova, A; Debreux, C; Lions, C; Poizot-Martin, I; Abel, S; Cabras, O; Cuzin, L; Guitteaud, K; Illiaquer, M; Pierre-François, S; Osei, L; Pasquier, J; Rome, K; Sidani, E; Turmel, J; Varache, C; Cabié, A; Atoui, N; Bistoquet, M; Delaporte, E; Le Moing, V; Meftah, N; de Boever, C Merle; Montes, B; Ferrer, a Montoya; Tuaillon, E; Reynes, J; André, M; Boyer, L; Bouillon, M; Delestan, M; Rabaud, C; May, T; Hoen, B; Allavena, C; Bernaud, C; Billaud, E; Biron, C; Bonnet, B; Bouchez, S; Boutoille, D; Brunet-Cartier, C; Deschanvres, C; Hall, N; Morineau, P; Reliquet, V; Sécher, S; Cavellec, M; Soria, A; Ferré, V; André-Garnier, E; Rodallec, A; Lefebvre, M; Grossi, O; Aubry, O; Raffi, F; Pugliese, P; Breaud, S; Ceppi, C; Chirio, D; Cua, E; Dellamonica, P; Demonchy, E; de Monte, A; Durant, J; Etienne, C; Ferrando, S; Michelangeli, C; Mondain, V; Naqvi, A; Oran, N; Perbost, I; Pillet, S; Pradier, C; Prouvost-Keller, B; Risso, K; Rio, V; Roger, P; Rosenthal, E; Sausse, S; Touitou, I; Wehrlen-Pugliese, S; Zouzou, G; Hocqueloux, L; Prazuck, T; Gubavu, C; Sève, A; Maka, A; Boulard, C; Thomas, G; Cheret, A; Goujard, C; Quertainmont, Y; Teicher, E; Lerolle, N; Deradji, O; Barrail-Tran, A; Landman, R; Joly, V; Ghosn, J; Rioux, C; Lariven, S; Gervais, A; Lescure, F; Matheron, S; Louni, F; Julia, Z; Mackoumbou-Nkouka, C; Le Gac, S; Charpentier, C; Descamps, D; Peytavin, G; Yazdanpanah, Y; Amazzough, K; Avettand-Fenoël, V; Benabdelmoumen, G; Bossi, P; Cessot, G; Charlier, C; Consigny, P; Danion, F; Dureault, A; Duvivier, C; Goesch, J; Guery, R; Henry, B; Jidar, K; Lanternier, F; Loubet, P; Lortholary, O; Louisin, C; Lourenco, J; Parize, P; Pilmis, B; Touam, F; Valantin, M; Tubiana, R; Agher, R; Seang, S; Schneider, L; Palich, R; Blanc, C; Katlama, C; Berger, J; N’guyen, Y; Lambert, D; Kmiec, I; Hentzien, M; Brunet, A; Brodard, V; Tattevin, P; Revest, M; Souala, F; Baldeyrou, M; Patrat-Delon, S; Chapplain, J; Benezit, F; Dupont, M; Poinot, M; Maillard, A; Pronier, C; Lemaitre, F; Guennoun, C; Poisson-Vanier, M; Jovelin, T; Sinteff, J; Arvieux, C; Botelho-Nevers, E; Frésard, A; Ronat, V; Lucht, F; Fischer, P; Partisani, M; Cheneau, C; Priester, M; Batard, M; Bernard-Henry, C; de Mautort, E; Fafi-Kremer, S; Alvarez, M; Biezunski, N; Debard, A; Delpierre, C; Lansalot, P; Lelièvre, L; Martin-Blondel, G; Piffaut, M; Porte, L; Saune, K; Delobel, Pierre; Ajana, F; Aïssi, E; Alcaraz, I; Baclet, V; Bocket, L; Boucher, A; Choisy, P; Huleux, T; Lafon-Desmurs, B; Meybeck, A; Pradier, M; Viget, N; Valette, M |
| Contributors: |
Hôpitaux Universitaires de Strasbourg (HUS); Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM); Infections Cardiovasculaires Virales et inflammation en pathologie humaine (CardioVir) UMR-S 1320 (CardioVir); Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-SFR CAP Santé (Champagne-Ardenne Picardie Santé); Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Hôpital universitaire Robert Debré Reims (CHU Reims); Hôpital universitaire Robert Debré Reims (CHU Reims); CHU Nice Cimiez; Hôpital Cimiez Nice (CHU); Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille); Centre Hospitalier de Tourcoing; Département Maladies Infectieuses et Tropicales CHRU Montpellier; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg); Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI); Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I (UY1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Cheikh Anta Diop de Dakar Sénégal (UCAD); Pathogénèse et contrôle des infections chroniques (PCCI); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM); Stratégies thérapeutiques contre l'infection VIH et les maladies virales associées iPLesp (THERAVIR); Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) |
| Source: |
ISSN: 0305-7453. |
| Publisher Information: |
CCSD; Oxford University Press (OUP) |
| Publication Year: |
2020 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
MESH: Adult; MESH: Cohort Studies; MESH: Incidence; MESH: Integrases; MESH: Retrospective Studies; MESH: Diabetes Mellitus* / chemically induced; MESH: Diabetes Mellitus* / epidemiology; MESH: HIV Infections* / complications; MESH: HIV Infections* / drug therapy; MESH: HIV Infections* / epidemiology; MESH: HIV Integrase Inhibitors* / adverse effects; MESH: HIV Integrase; MESH: Humans; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
| Description: |
International audience ; Background:Integrase strand transfer inhibitors (INSTIs) are increasingly used in patients living with HIV due to their safety, effectiveness and high genetic barrier. However, an association with weight gain has recently been suggested and several cases of diabetes mellitus have been reported with raltegravir and dolutegravir. The long-time metabolic impact of these recent molecules remains unclear.Objectives:To assess if an INSTI as a third agent is statistically associated with new-onset diabetes mellitus compared with an NNRTI or a PI. Patients and methods:Patients undergoing first-line combined ART (cART) without diabetes at baseline were retrospectively included from the Dat’AIDS French cohort study (ClinicalTrials.gov NCT02898987). Incident diabetes mellitus was defined as a notification of new diabetes in the medical history, a glycated haemoglobin (HbA1c) level superior to 7.5% or the start of a diabetes therapy following the initiation of ART. Results: From 2009 to 2017, 19 462 patients were included, among which 265 cases of diabetes mellitus occurred. Multivariate and survival analyses did not highlight an increase in new-onset diabetes in patients undergoing cART with an INSTI as a third agent compared with an NNRTI or a PI. BMI >30 kg/m2, age >37 years old (in survival analysis), black race or Hispanic ethnicity, arterial hypertension and AIDS were associated with a higher proportion of incident diabetes. Conclusions: INSTIs were not statistically associated with new-onset diabetes. However, clinicians should remain aware of this possible metabolic comorbidity, particularly in patients with a high BMI and older patients. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/32791523; PUBMED: 32791523 |
| DOI: |
10.1093/jac/dkaa330 |
| Availability: |
https://univ-reims.hal.science/hal-03253490; https://doi.org/10.1093/jac/dkaa330 |
| Accession Number: |
edsbas.D58DC5EE |
| Database: |
BASE |