| Title: |
Association between Quality of Life and Visual Acuity in a Randomized Clinical Trial of Patients with Uveitis Taking Antimetabolites |
| Authors: |
Chattopadhyay, Aheli; Rathinam; Gonzales, John A; Kelly, Nicole K; Thundikandy, Radhika; Kanakath, Anuradha; Murugan, S Bala; Vedhanayaki, R; Lim, Lyndell L; Suhler, Eric B; Al-Dhibi, Hassan A; Doan, Thuy; Ebert, Caleb D; Porco, Travis C; Acharya, Nisha R; Group, for the FAST Research |
| Source: |
Ocular Immunology and Inflammation, vol 32, iss 3 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2024 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3212 Ophthalmology and Optometry (for-2020); Neurosciences (rcdc); Behavioral and Social Science (rcdc); Clinical Research (rcdc); Eye Disease and Disorders of Vision (rcdc); Clinical Trials and Supportive Activities (rcdc); Eye (hrcs-hc); 3 Good Health and Well Being (sdg); Humans (mesh); Quality of Life (mesh); Antimetabolites (mesh); Health Status (mesh); Uveitis (mesh); Visual Acuity (mesh); Surveys and Questionnaires (mesh); Sickness Impact Profile (mesh); First-line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis Trial; health related quality of life; quality of life; vision related quality of life; visual acuity; FAST Research Group; 1107 Immunology (for); Ophthalmology & Optometry (science-metrix); 3204 Immunology (for-2020) |
| Subject Geographic: |
301 - 309 |
| Description: |
PURPOSE: To evaluate how changes in visual acuity are associated with changes in quality of life (QoL) among patients with non-infectious uveitis taking antimetabolites. METHODS: This secondary analysis of the multicenter First-line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis Trial involves 216 participants randomized to methotrexate or mycophenolate mofetil. Vision-related (NEI-VFQ and IND-VFQ) and health-related (PCS and MCS SF-36v2) QoL and visual acuity were measured at baseline and 6-month primary endpoint. RESULTS: Visual acuity was significantly associated and correlated with all QoL measures (Spearman correlation coefficients=0.5, 0.5, 0.3, and 0.4 for NEI-VFQ, IND-VFQ, SF-36v2 MCS and PCS, respectively). All observed changes in QoL met or exceeded the minimal clinically important difference definition on each scale. Treatment group was not significantly associated with any QoL measure. CONCLUSION: By adding insight beyond visual acuity, QoL provides a more comprehensive picture of the patient experience during uveitis treatment.Abbreviations and Acronyms: QoL = quality of life; VR-QoL = vision-related quality of life; HR-QoL = health-related quality of life; FAST = First-line Antimetabolites as Corticosteroid Sparing Treatment; NEI-VFQ = National Eye Institute Visual Functioning Questionnaire; IND-VFQ = Indian Visual Functioning Questionnaire; SF-36v2 = Medical Outcomes Study 36-Item Short Form Survey; PCS = physical component score; MCS = mental component score; 95% CI = 95% confidence interval; MCID = minimal clinically important difference. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt8qg2n6wr; https://escholarship.org/uc/item/8qg2n6wr; https://escholarship.org/content/qt8qg2n6wr/qt8qg2n6wr.pdf |
| DOI: |
10.1080/09273948.2023.2169714 |
| Availability: |
https://escholarship.org/uc/item/8qg2n6wr; https://escholarship.org/content/qt8qg2n6wr/qt8qg2n6wr.pdf; https://doi.org/10.1080/09273948.2023.2169714 |
| Rights: |
public |
| Accession Number: |
edsbas.D5BBC783 |
| Database: |
BASE |