Detection of Cancer with Serum miRNAs on an
| Title: | Detection of Cancer with Serum miRNAs on an |
|---|---|
| Authors: | Oligonucleotide Microarray; Dominic Suciu; Michael Lodes; Marcelo Caraballo; Amit Kumar; Brooke P. Anderson; Combimatrix Corporation Mukilteo |
| Contributors: | The Pennsylvania State University CiteSeerX Archives |
| Source: | http://files.shareholder.com/downloads/cbmx/438854770x0x274723/e2368d73-77ad-4127-ade3-32c6a59404a2/mirnaposter.pdf. |
| Collection: | CiteSeerX |
| Description: | MicroRNAs (miRNAs) are a class of small non-coding RNA species that play critical roles throughout cellular development and regulation. miRNA expression patterns taken from various tissue types often point to the cellular lineage of an individual tissue type, thereby being a more invariant hallmark of tissue type. Recent work has shown that these miRNA expression patterns can be used to classify tumor cells, and that this classification can be more accurate than the classification achieved by using messenger RNA gene expression patterns. One aspect of miRNA biogenesis that makes them particularly attractive as a biomarker is the fact that they are maintained in a protected state in serum and plasma, thus allowing the detection of miRNA expression patterns directly from serum. This study is focused on the evaluation of miRNA expression patterns in human serum for five types of human cancer: prostate, colon, ovarian, breast, and lung, using a pan-human-miRNA high-density microarray. This microarray platform enables the simultaneous analysis of all human miRNAs by either fluorescent or electrochemical signals and can be easily redesigned to include newly identified miRNAs. We show that sufficient miRNAs are present in one milliliter |
| Document Type: | text |
| File Description: | application/pdf |
| Language: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.4196 |
| Availability: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.4196; http://files.shareholder.com/downloads/cbmx/438854770x0x274723/e2368d73-77ad-4127-ade3-32c6a59404a2/mirnaposter.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: | edsbas.D60CFE2D |
| Database: | BASE |