| Title: |
Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury ; Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial |
| Authors: |
Taccone, Fabio Silvio; Rynkowski Bittencourt, Carla; Møller, Kirsten; Lormans, Piet; Quintana-Díaz, Manuel; Caricato, Anselmo; Cardoso Ferreira, Marco Antonio; Badenes, Rafael; Kurtz, Pedro; Søndergaard, Christian Baastrup; Colpaert, Kirsten; Petterson, Leticia; Quintard, Herve; Cinotti, Raphael; Gouvêa Bogossian, Elisa; Righy, Cassia; Silva, Serena; Roman-Pognuz, Erik; Vandewaeter, Catherine; Lemke, Daniel; Huet, Olivier; Mahmoodpoor, Ata; Blandino Ortiz, Aaron; van der Jagt, Mathieu; Chabanne, Russell; Videtta, Walter; Bouzat, Pierre; Vincent, Jean-Louis; Díaz, Claudia; Saravia, Andrés; Bayrlee, Ahmas; Nedolast, Laura; Elkambergy, Hussam; Siddique, Haamid; Mallat, Jihad; Aljaberi, Nahla; Shoshan, Samer; Mandi, Ayo; de Oliveira, Bruno; Prasanna, Malligere; Haque, Rehan; Munde, Dnyaneshwar; Chaffee, Sara; Alawadhi, Fatma; Dibu, Jamil; Junttila, Eija; Luoto, Teemu; Šteblaj, Simona; Creteur, Jacques; Durand, Dominique; Abbenhuijs, Caroline; Itesa Matumikina, Nancy; Annoni, Filippo; Nobile, Leda; Ulloa Bersatti, Miguel; Yovenko, Igor; Tsarev, Alexander; Dubois, Jasperina; Voets, Evy; Janssen, Luc; Zattera, Luigi; Pedrosa, Leire; Monleon Lopez, Berta; Serrano, Ainhoa; Romero-García, Nekane; Wittebole, Xavier; Dell'Anna, Antonio; Gelormini, Camilla; Stival, Eleonora; Marcos Neira, Pilar; Roig Pineda, Regina; Bielsa Berrocal, Lara; Misis del Campo, Maite; Bendel, Stepani; Mejía-Mantilla, Jorge; Marulanda, Ángela; Dabrowski, Wojciech; Damgaard Nielsen, Rune; Harboe Olsen, Markus; Ravnholt Jensen, Helene; Møller Larsen, Ida; Tallarico, Roberta; Lucangelo, Umberto; Gonzales Perez, Maria Isabel; Ichai, Carole; Asenhoune, Karim; Lakhal, Karim; Fernandez-Canal, Charlotte; Gay, Samuel; Lebouc, Marie; Bougon, David; Escudier, Etienne; Sirodot, Michel; Levrat, Albrice; Courouau, Alix; Duranteau, Jacques; Rodrigues, Aurore; Makouche, Naima; Francony, Gilles; Vincent, Olivier; Boucheix, Perrine; Schilte, Clotilde; Adolle, Anais; Gargadennec, Thomas; Dias, Patricia; Desanglois, Gwenaelle; Meheut, Alexia; Cam, Pauline; Meyfroidt, Geert; Mebis, Liese; Hendrickx, Alexandra; Wouters, Pieetr; van Hulle, Sylvia; d'Hondt, Alain; Beumier, Marjorie; Burgeois, Marc; Simonet, Olivier; Vallot, Frederic; Centeno, Pablo; Anchorena, Matias; Benavente, Ximena; d'Onofrio, Maximilian; Funes, Nydia; Barra de Oca, Antonio; Izzo, Gabriela; Castelain, Charlotte; Soetens, Filippo; Arias, Mario; Morocho, Diego; Jabaja, Manuel; Tutillo, Diego; Popugaev, Stan; Dias, Celeste; Perez Solada, Elena; Justo, Pilar; Lopez Gomez, Amparo; Alcantara, Sara; Chico, Francisco; Garcia, Maria Fernanda; Picoita, Fabricio; Velasco Eichler, Stela; Nonticuri Bianchi, Gabriela; Britz, João Pedro; Almeida Pimentel, Jaqueline; Fernandes, Mário Sérgio; Gharsallah, Hedi; Hajjej, Zied; Samoud, Walid; Grebenchikov, Oleg; Likhvantsev, Valery; Stroiteleva, Elena; Markou, Nikolaos; Bakali, Dimitra; Koutrafouri, Dionysia; Subhy Alsheikhly, Ahmed; Giacomucci, Angelo; Maccherani, Sara; Horn, Janneke; Elbahnasawy, Mohamed; Ahmadi, Arezoo; Decaesteker, Lien; Decruyenaere, Daphne; Demeersseman, Ruth; Devriendt, Yves; Embo, Karen; van Duijn, Ditty; Ormskerk, Patricia; Glasbergen-van Beijeren, Melanie; Njimi, Hassane; Cariou, Alain; Lelubre, Christophe; Ristagno, Giuseppe; Stocchetti, Nino; Oddo, Mauro; de Deyne, Cathy; Citerio, Giuseppe |
| Contributors: |
Université libre de Bruxelles = Free University of Brussels (ULB); Copenhagen University Hospital Denmark = Københavns Universitetshospital Danmark (KUH); University of Copenhagen = Københavns Universitet (UCPH); Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart Roma (Unicatt); Universitat Politècnica de València = Universitad Politecnica de Valencia = Polytechnic University of Valencia (UPV); D'Or Institute for Research and Education Rio de Janeiro; Instituto Estadual do cerebro Paulo Niemeyer; Ghent University Hospital; Hôpitaux Universitaires de Genève = University Hospital of Geneva Genève (HUG); methodS in Patients-centered outcomes and HEalth ResEarch (SPHERE); Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR des Sciences Pharmaceutiques et Biologiques (Nantes Univ - UFR Pharmacie); Nantes Université - pôle Santé; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ); Service d'anesthésie et réanimation chirurgicale Nantes; Hôtel-Dieu-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Neurocritical care, ULB; CHRU Brest - Département d'Anesthésie Réanimation (CHU - BREST - DAR); Centre Hospitalier Régional Universitaire de Brest (CHRU Brest); Optimisation des régulations physiologiques (ORPHY (EA 4324)); Université de Brest (UBO EPE)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM); Université de Brest (UBO EPE)-Université de Brest (UBO EPE); Erasmus University Medical Center Rotterdam (Erasmus MC); CHU Clermont-Ferrand; GIN Grenoble Institut des Neurosciences (GIN); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA); Université Grenoble Alpes (UGA) |
| Source: |
ISSN: 0098-7484. |
| Publisher Information: |
CCSD; American Medical Association (AMA) |
| Publication Year: |
2024 |
| Collection: |
Université François-Rabelais de Tours: HAL |
| Subject Terms: |
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; Importance Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective To assess the impact on neurological outcome of 2 different hemoglobin thresholds to guide red blood cell transfusions in patients with acute brain injury. Design, Setting, and Participants Multicenter, phase 3, parallel-group, investigator-initiated, pragmatic, open-label randomized clinical trial conducted in 72 intensive care units across 22 countries. Eligible patients had traumatic brain injury, aneurysmal subarachnoid hemorrhage, or intracerebral hemorrhage; hemoglobin values below 9 g/dL within the first 10 days after injury; and an expected intensive care unit stay of at least 72 hours. Enrollment occurred between September 1, 2017, and December 31, 2022. The last day of follow-up was June 30, 2023. Interventions Eight hundred fifty patients were randomly assigned to undergo a liberal (transfusion triggered by hemoglobin |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1001/jama.2024.20424 |
| Availability: |
https://hal.science/hal-04820199; https://doi.org/10.1001/jama.2024.20424 |
| Accession Number: |
edsbas.D6367CCD |
| Database: |
BASE |