| Title: |
Health-related quality of life in nondialysis CKD patients: a comprehensive description of five-year trajectories among the CKD–REIN cohort |
| Authors: |
Moustapha Faye; Lisa Le Gall; Aghilès Hamroun; Lucile Montalescot; Karen Leffondre; Natalia Alencar de Pinho; Bénédicte Stengel; Adama Faye; Luc Frimat; Abdou Omorou; on behalf of the CKD–REIN study collaborators |
| Source: |
BMC Nephrology, Vol 27, Iss 1, Pp 1-13 (2026) |
| Publisher Information: |
BMC |
| Publication Year: |
2026 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Chronic kidney disease; Clinical epidemiology; Cohort studies; Mental component summary; Physical component summary; Diseases of the genitourinary system. Urology; RC870-923 |
| Description: |
Background Few studies have analyzed the quality-of-life trajectories of CKD patients not receiving kidney replacement therapy, and the results are inconsistent. This study aimed to identify subgroups of long-term trajectories of the physical (PCS) and mental components summary (MCS) of the KDQOL-36 in patients with CKD stages 3–5 and to describe their associations with patient characteristics. Methods We used a joint latent class–mixed model to identify the PCS and MCS trajectories of 2716 patients with CKD stages 3–5 enrolled in the CKD–Renal Epidemiology and Information Network (CKD–REIN) cohort study. Quality-of-life was assessed annually using the Kidney Disease Quality-of-life-36. All the participants had scores for at least one-time point. Results During a median follow-up of 5.56 (4.77–6.16) years, 664 participants started KRT, and 465 died before KRT. We identified three profiles of PCS: a “High and declining PCS trajectory” which included 5.89% of patients, characterized by a higher initial score and a decline of more than 10 points over three years; a “High and stable PCS trajectory” in 50.96%, characterized by a higher initial score that remained stable; and a “Low and stable PCS trajectory” in 43.15%, characterized by a lower initial score that remained stable. For MCS, we identified a single, stable mean trajectory over time. A decline in eGFR was faster in participants with a “High and declining PCS trajectory” (-4.30 mL/min per years). Patients in the high and stable trajectory had a more favorable clinical and biological profile at baseline. The evolution of the specific dimensions of CKD within each PCS trajectory followed a pattern similar to that of the PCS itself. Conclusions The study highlights substantial heterogeneity in PCS evolution in patients with CKD, which contrasts with the stability of that for MCS. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1186/s12882-025-04702-2; https://doaj.org/toc/1471-2369; https://doaj.org/article/cbb9c23f321a417484f27d810f6ce1e4 |
| DOI: |
10.1186/s12882-025-04702-2 |
| Availability: |
https://doi.org/10.1186/s12882-025-04702-2; https://doaj.org/article/cbb9c23f321a417484f27d810f6ce1e4 |
| Accession Number: |
edsbas.D67CAB03 |
| Database: |
BASE |