Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics
| Title: | Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics |
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| Authors: | Beaumont RN; Warrington NM; Cavadino A; Tyrrell J; Nodzenski M; Horikoshi M; Geller F; Myhre R; Richmond RC; Paternoster L; Bradfield JP; Kreiner-Moller E; Huikari V; Metrustry S; Lunetta KL; Painter JN; Hottenga J-J; Allard C; Barton SJ; Espinosa A; Marsh JA; Potter C; Zhang G; Ang W; Berry DJ; Bouchard L; Das S; Hakonarson H; Heikkinen J; Helgeland O; Hocher B; Hofman A; Inskip HM; Jones SE; Kogevinas M; Lind PA; Marullo L; Medland SE; Murray A; Murray JC; Njolstad PR; Nohr EA; Reichetzeder C; Ring SM; Ruth KS; Santa-Marina L; Scholtens DM; Sebert S; Sengpiel V; Tuke MA; Vaudel M; Weedon MN; Willemsen G; Wood AR; Yaghootkar H; Muglia LJ; Bartels M; Relton CL; Pennell CE; Chatzi L; Estivill X; Holloway JW; Boomsma DI; Montgomery GW; Murabito JM; Spector TD; Power C; Jarvelin M-R; Bisgaard H; Grant SFA; Sorensen TIA; Jaddoe VW; Jacobsson B; Melbye M; McCarthy MI; Hattersley AT; Hayes MG; Frayling TM; Hivert M-F; Felix JF; Hypponen E; Lowe WL; Evans DM; Lawlor DA; Feenstra B; Freathy RM |
| Source: | Human Molecular Genetics, 15 February 2018 |
| Publisher Information: | Oxford University Press |
| Publication Year: | 2018 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | © The Author(s) 2018. Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86 577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structural equation modelling (SEM) and analyses of mother-child pairs to quantify the separate maternal and fetal genetic effects. Maternal SNPs at 10 loci (MTNR1B, HMGA2, SH2B3, KCNAB1, L3MBTL3, GCK, EBF1, TCF7L2, ACTL9, CYP3A7) were associated with offspring birth weight at P |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/246217; https://eprints.ncl.ac.uk/fulltext.aspx?url=246217/32BA20CD-B958-4C8F-8A52-BDE5C3E29183.pdf&pub_id=246217 |
| Availability: | https://eprints.ncl.ac.uk/246217 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.D6A67F5 |
| Database: | BASE |