| Title: |
Polymeric nanoparticles for the substained release of a prodrug of zidovudine obtained by its conjugation with the ursodeoxycholic acid |
| Authors: |
A. Dalpiaz; M. Fogagnolo; D. Perrone; C. Contado; B. Pavan; G. Paganetto; VIGHI, Eleonora; IANNUCCELLI, Valentina; LEO, Eliana Grazia |
| Contributors: |
A., Dalpiaz; M., Fogagnolo; D., Perrone; C., Contado; B., Pavan; G., Paganetto; Vighi, Eleonora; Iannuccelli, Valentina; Leo, Eliana Grazia |
| Publisher Information: |
ND; ITA |
| Publication Year: |
2012 |
| Collection: |
Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| Subject Terms: |
nanopartcle; zidovudine; ursodeoxycholic acid |
| Description: |
We report a study of encapsulation and release from PLGA nanoparticles of a prodrug of zidovudine obtained by its ester conjugation with a bile acid, the ursodeoxycholic acid. The free prodrug was hydrolizated in rat liver homogenates with an half life of 2.7 min, whereas the loaded NP nanoparticles appeared able to significantly stabilize the prodrug in this physiological fluid. |
| Document Type: |
conference object |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
ispartofbook:XXII Simposio ADRITELF 2012; XXII Simposium ADRITELF 2012; volume:ND; firstpage:83; lastpage:83; https://hdl.handle.net/11380/856093 |
| Availability: |
https://hdl.handle.net/11380/856093 |
| Accession Number: |
edsbas.D6AA94CF |
| Database: |
BASE |