| Title: |
Role of autacoids in cardiovascular collapse in anaphylactic shock in anesthetized dogs |
| Authors: |
Mink, S.; Becker, A.; Sharma, S.; Unruh, H.; Duke, K.; Kepron, W. |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
1999 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Original Article |
| Description: |
Objective: In anaphylactic shock (AS), the relative effects of the autacoids including histamine, prostaglandins (prost), and leukotrienes (leuk) on causing cardiovascular collapse and the extent to which receptor blocking agents and pathway inhibitors may prevent this collapse are not clear. Methods: In randomized design, we investigated whether blockade of histamine H 1 , H 2 , and H 3 receptors or inhibition of the cyclooxygenase (cyclo) and lipoxygenase pathways (lipox) prevented AS in ragweed sensitized dogs. Seven dogs were studied under pentobarbital anesthesia in which the treatment studies were approximately 2 weeks apart. Results: During H 1 receptor blockade, the decreases in blood pressure and cardiac output otherwise observed in AS were attenuated ( P |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://cardiovascres.oxfordjournals.org/cgi/content/short/43/1/173; http://dx.doi.org/10.1016/S0008-6363(99)00073-5 |
| DOI: |
10.1016/S0008-6363(99)00073-5 |
| Availability: |
http://cardiovascres.oxfordjournals.org/cgi/content/short/43/1/173; https://doi.org/10.1016/S0008-6363(99)00073-5 |
| Rights: |
Copyright (C) 1999, European Society of Cardiology |
| Accession Number: |
edsbas.D6B22BB6 |
| Database: |
BASE |