| Title: |
Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission |
| Authors: |
Lipina, Tatiana V; Prasad, Tuhina; Yokomaku, Daisaku; Luo, Lin; Connor, Steven A; Kawabe, Hiroshi; Wang, Yu Tian; Brose, Nils; Roder, John C; Craig, Ann Marie |
| Contributors: |
Lipina, Tatiana V; Prasad, Tuhina; Yokomaku, Daisaku; Luo, Lin; Connor, Steven A; Kawabe, Hiroshi; Wang, Yu Tian; Brose, Nils; Roder, John C; Craig, Ann Marie |
| Publication Year: |
2016 |
| Collection: |
Georg-August-Universität Göttingen: GoeScholar |
| Description: |
Calsyntenin-2 has an evolutionarily conserved role in cognition. In a human genome-wide screen, the CLSTN2 locus was associated with verbal episodic memory, and expression of human calsyntenin-2 rescues the associative learning defect in orthologous Caenorhabditis elegans mutants. Other calsyntenins promote synapse development, calsyntenin-1 selectively of excitatory synapses and calsyntenin-3 of excitatory and inhibitory synapses. We found that targeted deletion of calsyntenin-2 in mice results in a selective reduction in functional inhibitory synapses. Reduced inhibitory transmission was associated with a selective reduction of parvalbumin interneurons in hippocampus and cortex. Clstn2(-/-) mice showed normal behavior in elevated plus maze, forced swim test, and novel object recognition assays. However, Clstn2(-/-) mice were hyperactive in the open field and showed deficits in spatial learning and memory in the Morris water maze and Barnes maze. These results confirm a function for calsyntenin-2 in cognitive performance and indicate an underlying mechanism that involves parvalbumin interneurons and aberrant inhibitory transmission. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
26171716 |
| Relation: |
000368084100017; 3141741 |
| DOI: |
10.1038/npp.2015.206 |
| Availability: |
https://resolver.sub.uni-goettingen.de/purl?gro-2/557; https://doi.org/10.1038/npp.2015.206 |
| Rights: |
https://publications.goettingen-research-online.de/license ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.D70E1B9F |
| Database: |
BASE |