| Title: |
Sickle cell disease in western Sudan: genetic epidemiology and predictors of knowledge attitude and practices |
| Authors: |
Daak, Ahmed A.; Elsamani, Elfatih; Ali, Eltigani H.; Mohamed, Fatma A; Abdel‐Rahman, Manar E.; Elderdery, Abozer Y.; Talbot, Octavious; Kraft, Peter; Ghebremeskel, Kebreab; Elbashir, Mustafa I.; Fawzi, Wafaie |
| Source: |
Tropical Medicine & International Health ; volume 21, issue 5, page 642-653 ; ISSN 1360-2276 1365-3156 |
| Publisher Information: |
Wiley |
| Publication Year: |
2016 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Summary Objective To investigate the epidemiology of sickle cell disease ( SCD ) and determinants of knowledge, attitudes and practices ( KAP ) towards SCD in western Kordofan State, Sudan. Methods A community‐based, descriptive, cross‐sectional study was conducted in three towns. Three hundred and seventy‐two households were polled, and blood samples for haemoglobin phenotyping were collected from 1116 individuals. Sociodemographic, socio‐economic and KAP data were collected using investigator‐administered questionnaires. Descriptive, frequency distribution and multiple regression analyses were performed. Results About 50.9% of the study population were Misseriya tribes. Consanguineous marriages were reported by 67.5% of the households. The highest percentage of homozygous SCD was 2.8% among children under 5 years of age. About 24.9% were carriers of HbS allele (Hb AS ). HbS allele frequency was highest in children aged 5–11 years (18.3%, CI : 13.7–22.9%) and lowest in males >15 years old (12.0%, CI : 6.1–17.9%). The average HbS frequency across all age groups was 14.5% (95% CI : 12.2–16.8%). The most frequent β ‐globin gene cluster haplotype was the Cameroon (30.8%), followed by the Benin (21.8%), the Senegal (12.8%) and the Bantu (2.2%) haplotypes. About 17.0% of all‐cause child deaths were due to SCD . The estimated change in log odds of having the SS genotype per year increase in age was (−) 0.0058 (95% CI −0.0359, 0.0242). This represents a non‐statistically significant 2.9% increase in 5‐year mortality for individuals with the SS genotype relative to those with AS and AA genotypes. About 46.9% of the households had poor knowledge, 26.1% had satisfactory knowledge, and 26.9% had good knowledge about sickle cell disease. Mothers' and fathers' educational levels were significant predictors of good knowledge about SCD ( P < 0.05). About 48.0% had a satisfactory attitude towards sickle cell disease while 30.7% had poor attitude and only 21.3 showed good attitudes. Poor knowledge about SCD and low ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/tmi.12689 |
| Availability: |
https://doi.org/10.1111/tmi.12689; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ftmi.12689; https://onlinelibrary.wiley.com/doi/pdf/10.1111/tmi.12689 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.D7A01860 |
| Database: |
BASE |