| Title: |
Spray Drying for the Preparation of Nanoparticle-Based Drug Formulations as Dry Powders for Inhalation |
| Authors: |
Maria Malamatari; Anastasia Charisi; Stavros Malamataris; Kyriakos Kachrimanis; Ioannis Nikolakakis |
| Source: |
Processes, Vol 8, Iss 788, p 788 (2020) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2020 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
drug nanoparticles; dry powder inhalers; nanoparticle agglomerates; pulmonary drug delivery; spray drying; Chemical technology; TP1-1185; Chemistry; QD1-999 |
| Description: |
Nanoparticle-based therapeutics have been used in pulmonary formulations to enhance delivery of poorly water-soluble drugs, protect drugs against degradation and achieve modified release and drug targeting. This review focuses on the use of spray drying as a solidification technique to produce microparticles containing nanoparticles (i.e., nanoparticle (NP) agglomerates) with suitable properties as dry powders for inhalation. The review covers the general aspects of pulmonary drug delivery with emphasis on nanoparticle-based dry powders for inhalation and the principles of spray drying as a method for the conversion of nanosuspensions to microparticles. The production and therapeutic applications of the following types of NP agglomerates are presented: nanoporous microparticles, nanocrystalline agglomerates, lipid-based and polymeric formulations. The use of alternative spray-drying techniques, namely nano spray drying, and supercritical CO 2 -assisted spray drying is also discussed as a way to produce inhalable NP agglomerates. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/2227-9717/8/7/788; https://doaj.org/toc/2227-9717; https://doaj.org/article/b01c27d9fff14487928f7a91eee129ed |
| DOI: |
10.3390/pr8070788 |
| Availability: |
https://doi.org/10.3390/pr8070788; https://doaj.org/article/b01c27d9fff14487928f7a91eee129ed |
| Accession Number: |
edsbas.D7C02323 |
| Database: |
BASE |