| Title: |
Analysis of 1-Year Clinical Outcomes in the SIRIUS Trial ; A Randomized Trial of a Sirolimus-Eluting Stent Versus a Standard Stent in Patients at High Risk for Coronary Restenosis |
| Authors: |
Holmes, David R.; Leon, Martin B.; Moses, Jeffrey W.; Popma, Jeffrey J.; Cutlip, Donald; Fitzgerald, Peter J.; Brown, Charles; Fischell, Tim; Wong, Shing Chiu; Midei, Mark; Snead, David; Kuntz, Richard E. |
| Source: |
Circulation ; volume 109, issue 5, page 634-640 ; ISSN 0009-7322 1524-4539 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2004 |
| Description: |
Background— This study evaluated a large group of patients enrolled in a double-blind randomized trial of the sirolimus-eluting stent to document whether the initial clinical improvement seen in previous smaller series is maintained out to 12 months and to study the potential treatment effect in patient subsets known to be at increased risk of restenosis. Methods and Results— A total of 1058 patients with de novo native coronary stenosis undergoing clinically indicated percutaneous coronary intervention were randomly assigned to sirolimus-eluting stent (533) or control bare stent (525). Procedural success and in-hospital outcomes were excellent and did not differ between the 2 groups. At 9 months, clinical restenosis, defined as target-lesion revascularization, was 4.1% in the sirolimus limb versus 16.6% in the control limb ( P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/01.cir.0000112572.57794.22 |
| DOI: |
10.1161/01.CIR.0000112572.57794.22 |
| Availability: |
https://doi.org/10.1161/01.cir.0000112572.57794.22; https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000112572.57794.22 |
| Accession Number: |
edsbas.D82E8F5 |
| Database: |
BASE |