| Title: |
Genetic studies of body mass index yield new insights for obesity biology |
| Authors: |
Locke,Adam E.; Kahali,Bratati; Berndt,Sonja I.; Justice,Anne E.; Pers,Tune H.; Day,Felix R.; Powell,Corey; Vedantam,Sailaja; Buchkovich,Martin L.; Yang,Jian; Croteau-Chonka,Damien C.; Esko,Tonu; Fall,Tove; Ferreira,Teresa; Gustafsson,Stefan; Kutalik,Zoltan; Luan,Jian'an; Maegi,Reedik; Randall,Joshua C.; Winkler,Thomas W.; Wood,Andrew R.; Workalemahu,Tsegaselassie; Faul,Jessica D.; Smith,Jennifer A.; Zhao,Jing Hua; Zhao,Wei; Chen,Jin; Fehrmann,Rudolf; Hedman,Asa K.; Karjalainen,Juha; Schmidt,Ellen M.; Absher,Devin; Amin,Najaf; Anderson,Denise; van der Laan, Sander W.; van Setten, Jessica; Uh, Hae-Won; den Ruijter, Hester M.; Moll, Frans L.; Pasterkamp, Gerard; Asselbergs, Folkert W.; de Bakker, Paul I. W.; Zanen, Pieter; LifeLines Cohort Study; ADIPOGen Consortium; AGEN-BMI Working Grp; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; Int Endogene Consortium; Experimentele Afd. Cardiologie 1; Onderzoek Vrouw Hart & Vaatziekten; Circulatory Health; CMM Groep Kaaij; Brain; JC onderzoeksprogramma Methodology; Cancer; Afdeling Longfunctie; Epi Kanker Team 1; JC onderzoeksprogramma Cancer; MS VPG/Gynaecologie; Child Health; Epi Kanker Team A; JC onderzoeksprogramma Cardiovascular Health; Cardiovasculaire Epidemiologie; Cardiovasculaire Epi Team 4; Cardiovasculaire Epi Team 5 |
| Publication Year: |
2015 |
| Subject Terms: |
GENOME-WIDE ASSOCIATION; PROVIDES INSIGHTS; GLYCEMIC TRAITS; HUMAN HEIGHT; LOCI; METAANALYSIS; VARIANTS; EXPRESSION; PATHWAYS; ARCHITECTURE; Taverne |
| Description: |
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0028-0836 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/331855 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/331855 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.D85E101D |
| Database: |
BASE |