Comparative analysis of RNA expression identifies effective targeted drug in myoepithelial carcinoma
| Title: | Comparative analysis of RNA expression identifies effective targeted drug in myoepithelial carcinoma |
|---|---|
| Authors: | Yvonne A. Vasquez; Lauren Sanders; Holly C. Beale; A. Geoffrey Lyle; Ellen T. Kephart; Katrina Learned; Jennifer Peralez; Amy Li; Min Huang; Kimberly A. Pyke-Grimm; Serena Y. Tan; Sofie R. Salama; David Haussler; Isabel Bjork; Olena M. Vaske; Sheri L. Spunt |
| Source: | npj Precision Oncology, Vol 9, Iss 1, Pp 1-8 (2025) |
| Publisher Information: | Nature Portfolio |
| Publication Year: | 2025 |
| Collection: | Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282 |
| Description: | Myoepithelial carcinoma is an ultra-rare pediatric solid tumor with no targeted treatments. Clinical implementation of tumor RNA sequencing (RNA-Seq) for identifying therapeutic targets is underexplored in pediatric cancer. We previously published the Comparative Analysis of RNA Expression (CARE), a framework for incorporating RNA-Seq-derived gene expression into the clinic for difficult-to-treat pediatric cancers. Here, we discuss a 4-year-old male diagnosed with myoepithelial carcinoma who was treated at Stanford Medicine Children’s Health. A metastatic lung nodule from the patient underwent standard-of-care tumor DNA profiling and CARE analysis, wherein the patient’s tumor RNA-Seq profile was compared to over 11,000 uniformly analyzed tumor profiles from public data repositories. DNA profiling yielded no actionable mutations. CARE identified overexpression biomarkers and nominated a treatment that produced a durable clinical response. These findings underscore the utility of data sharing and concurrent analysis of large genomic datasets for clinical benefit, particularly for rare cancers with unknown biological drivers. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | https://doi.org/10.1038/s41698-025-00918-5; https://doaj.org/toc/2397-768X; https://doaj.org/article/0e1291c4928143a7ab8932852bda69d6 |
| DOI: | 10.1038/s41698-025-00918-5 |
| Availability: | https://doi.org/10.1038/s41698-025-00918-5; https://doaj.org/article/0e1291c4928143a7ab8932852bda69d6 |
| Accession Number: | edsbas.D89B5014 |
| Database: | BASE |