| Title: |
RADIATION THERAPY |
| Authors: |
Behera, Manoj K.; Sharma, Aman; Dutta, Samrat; Sharma, Seema; Julka, P.K.; Rath, G.K.; Kil, Whoon Jong; Ko, Christine; Kaushal, Aradhana; Warran, Kathy; Ning, Holly; Camphausen, Kevin; Smart, DeeDee; Vern-Gross, Tamara Z.; McMullen, Kevin P.; Case, L.D.; Bourland, J.D.; Ellis, Thomas L.; Lawrence, Julia A.; Tatter, Stephen B.; Shaw, Edward G.; Urbanic, Jim J.; Chan, Michael D.; Jensen, Randy L.; Shrieve, Dennis C.; Mohindra, Pranshu; Robins, H Ian; Tome, Wolfgang A.; Howard, Steven P.; Chen, Changhu; Damek, Denise; Gaspar, Laurie E.; Ney, Douglas; Waziri, Allen; Lillehei, Kevin; Kavanagh, Brian D.; Wang, Che-Chuan; Floyd, Scott; Chang, Chin-Hong; Warnke, Peter; Chio, Chung-Ching; Kasper, Ekkehard; Mahadevan, Anand; Wong, Eric; Jeyapalan, Suriya; Chen, Clark; Mahajan, Anita; Grosshans, David; McAleer, Mary Francis; Brown, Paul D.; Chintagumpala, Murali; Vats, Tribhawan; Puduvalli, Vinay; Yock, Torunn; Schulder, Michael; Herschmann, Yehuda; Ghaly, Maged; Knisely, Jonathan; Kapur, Ajay; Goetz, Pablo; Lwu, Shelly; Ebinu, Julius; Arayee, Mandana; Monsalves, Eric; Laperriere, Normand; Menard, Cynthia; Bernstein, Mark; Zadeh, Gelareh; Loganathan, Amritraj G.; Alphonse, Natalie; Peiffer, Ann M.; Johnson, Annette; Urbanic, James J.; Saconn, Paul A.; Munley, Michael T.; Aryaee, Mandana; Laperriere, Norm; Lowe, Clark; DeGroot, John; Mark, Gilbert; Vats, Tribhavan; Rudà, Roberta; Trevisan, Elisa; Magliola, Umberto; Bertero, Luca; Bosa, Chiara; Ricardi, Umberto; Soffietti, Riccardo; Rajappa, Prajwal; Margetis, Konstantinos; Wernicke, A Gabriella; Sherr, David L.; Lavi, Ehud; Fine, Robert L.; Schwartz, Theodore; Pannullo, Susan C.; Laack, Nadia; Blanchard, Miran; Buckner, Jan; Glass, Jon; Andrews, David W.; Werner-Wasik, Maria; Evans, James; Lawrence, Yaakov R.; Shi, Wenyin; Strauss, Ido; Corn, Benjamin W.; Matceyevsky, Diana; Alani, Shlomi; Gez, Elijahu; Shtraus, Natan; Kanner, Andrew A.; Spasic, Marko; Choy, Winward; Nagasawa, Daniel; Yang, Isaac; Noel, Michael; Woolf, Eric; Smith, Ryan; Castillo-Rojas, Patricia; Sorenson, Stephen; Smith, Kris; Scheck, Adrienne C.; Han, Seunggu J.; Oh, Michael C.; Sughrue, Michael E.; Rutkowski, Martin J.; Aranda, Derick; Barani, Igor J.; Parsa, Andrew T.; Redmond, Kristin J.; Horska, Alena; Ishaq, Omar; Ford, Eric; McNutt, Todd; Batra, Sachin; Kleinberg, Lawrence; Wharam, Moody; Mahone, Mark; Terezakis, Stephanie; Ryu, Samuel; Rock, Jack; Movsas, Benjamin; Mikkelsen, Tom; Rosenblum, Mark; Sabsevitz, David; Bovi, Joseph A.; Leo, Peter; LaViolette, Peter; Rand, Scott; Mueller, Wade; Phillips, Andrew; Venkatramani, Rajkumar; Olch, Arthur; Grimm, John; Davidson, Tom; Brown, Robert; Dhall, Girish; Finlay, Jonathan; Wong, Kenneth |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2011 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Abstracts |
| Description: |
INTRODUCTION: Craniopharyngioma remains a challenging disease to treat because of its proximity to a critical organ and the young age of patients at presentation. Radiation therapy plays a pivotal role in the local control of the disease. MATERIALS AND METHODS: In this study, we retrospectively analyzed the records of all patients with craniopharyngioma treated in the Department of Radiotherapy at our institute from 2007 to 2009. RESULTS: Sixty-two patients were treated during this period (72.5% male and 27.5% female). The mean age of patients was 20 years (range, 5-68 years; median, 16 years). Visual impairment was the most common presenting symptom (86%), followed by headache (65%) and vomiting (24%). The mean duration of symptoms was 14.6 months. The majority of the patients (76%) underwent subtotal excision, while 24% of patients underwent total resection. Repeat surgery was done in 7 patients. All patients received postoperative radiotherapy: 35% of patients received radiation by a 2-field technique on a telecobalt machine, and 65% received radiation by 3DCRT on a linear accelerator. Only 8% of patients received stereotactic radiotherapy (SRT). Median follow-up was 11.6 months (range, 1-14.8 months). Only 32 patients remained on follow-up. Sixteen patients developed late toxicity, which included diabetes insipidus, growth failure, and blindness. Ten patients had persistent radiological evidence of residual disease. CONCLUSION: The mean age at presentation and symptom complex in our patients were comparable with reports from other case series. Most of our patients underwent 3D conformal radiotherapy following surgery. The role of SRT/stereotactic radiosurgery is still evolving in our setup. Poor follow-up remains a concern. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://neuro-oncology.oxfordjournals.org/cgi/content/short/13/suppl_3/iii127; http://dx.doi.org/10.1093/neuonc/nor160 |
| DOI: |
10.1093/neuonc/nor160 |
| Availability: |
http://neuro-oncology.oxfordjournals.org/cgi/content/short/13/suppl_3/iii127; https://doi.org/10.1093/neuonc/nor160 |
| Rights: |
Copyright (C) 2011, Society for Neuro-Oncology (SNO) |
| Accession Number: |
edsbas.D8CA13F1 |
| Database: |
BASE |