| Title: |
A-100 A Mini-Meta Analysis on Alzheimer’s Disease and Aggression/Agitation Behaviors |
| Authors: |
Gallegos, Adrianna C; Shields, Michelle; Singer, Gage; Thayer, Rachel E |
| Source: |
Archives of Clinical Neuropsychology ; volume 37, issue 6, page 1252-1252 ; ISSN 1873-5843 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2022 |
| Description: |
Objective: This meta-analysis used primary studies that examined gender differences and behavior disturbances observed in Alzheimer’s disease (ad). Aggression/agitation behaviors become prevalent in advanced cases, with anxiety and problematic conduct more likely in men and sleep and mood disturbances in women, which can adversely impact cognition, rate of decline, and functionality (Lee et al., 2017). Therefore, this analysis hypothesized that men with ad are more likely to report aggression/agitation symptomology than women. Data Selection: Inclusionary criteria of primary studies (N = 6) dictated that each must have researched ad samples, included measures of aggression/agitation, and reported mean differences between genders, allowing for Cohen’s d calculations, with searches conducted in February 2022. Cohen’s d was used for summary effects. Data Synthesis: This analysis utilized a weighted random-effects model for summary synthesis. This model effectively synthesizes real-world data because it assumes variation in estimates comes from multiple sources rather than one true value, indicating heterogeneity. The resulting summary effect (N = 1575, Cohen’s d = 0.09, Z test = 1.24, p-value = 0.213) indicated statistical non-significance, such that gender differences were not observed on average. Conclusions: This analysis suggests that differences between gender and aggressive/agitated behavior are not robust. Mixed results among the primary studies suggest that gender differences may exist in ad-related behavior. Still, few studies met the inclusion criteria of this analysis as they did not examine or provide mean differences for gender or provide data required to calculate an effect size. Future research should include other facets of behavior for a more comprehensive meta-analysis. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/arclin/acac060.100 |
| Availability: |
https://doi.org/10.1093/arclin/acac060.100; https://academic.oup.com/acn/article-pdf/37/6/1252/45498596/acac060.100.pdf |
| Rights: |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| Accession Number: |
edsbas.D8EADF3 |
| Database: |
BASE |