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Validating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry

Title:	Validating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry
Authors:	Ding, Wern Yew; Fawzy, Ameenathul Mazaya; Romiti, Giulio Francesco; Proietti, Marco; Pastori, Daniele; Huisman, Menno V.; Lip, Gregory Y. H.; Abban, Dzifa Wosornu; Abdul, Nasser; Abud, Atilio Marcelo; Adams, Fran; Addala, Srinivas; Adragão, Pedro; Ageno, Walter; Aggarwal, Rajesh; Agosti, Sergio; Agostoni, Piergiuseppe; Aguilar, Francisco; Linares, Julio Aguilar; Aguinaga, Luis; Ahmed, Jameel; Aiello, Allessandro; Ainsworth, Paul; Aiub, Jorge Roberto; Al-Dallow, Raed; Alderson, Lisa; Velasco, Jorge Antonio Aldrete; Alexopoulos, Dimitrios; Manterola, Fernando Alfonso; Aliyar, Pareed; Alonso, David; da Costa, Fernando Augusto Alves; Amado, José; Amara, Walid; Amelot, Mathieu; Amjadi, Nima; Ammirati, Fabrizio; Andrade, Marianna; Andrawis, Nabil; Annoni, Giorgio; Ansalone, Gerardo; Ariani, M. Kevin; Arias, Juan Carlos; Armero, Sébastien; Arora, Chander; Aslam, Muhammad Shakil; Asselman, M.; Audouin, Philippe; Augenbraun, Charles; Aydin, S.; Ayryanova, Ivaneta; Aziz, Emad; Backes, Luciano Marcelo; Badings, E.; Bagni, Ermentina; Baker, Seth H.; Bala, Richard; Baldi, Antonio; Bando, Shigenobu; Banerjee, Subhash; Bank, Alan; Esquivias, Gonzalo Barón; Barr, Craig; Bartlett, Maria; Kes, Vanja Basic; Baula, Giovanni; Behrens, Steffen; Bell, Alan; Benedetti, Raffaella; Mazuecos, Juan Benezet; Benhalima, Bouziane; Bergler-Klein, Jutta; Berneau, Jean-Baptiste; Berrospi, Percy; Berti, Sergio; Berz, Andrea; Best, Elizabeth; Bettencourt, Paulo; Betzu, Robert; Bhagwat, Ravi; Bhatta, Luna; Biscione, Francesco; Bisignani, Giovanni; Black, Toby; Bloch, Michael J.; Bloom, Stephen; Blumberg, Edwin; Bo, Mario; Bøhmer, Ellen; Bollmann, Andreas; Bongiorni, Maria Grazia; Boriani, Giuseppe; Boswijk, D. J.; Bott, Jochen; Bottacchi, Edo; Kalan, Marica Bracic; Bradman, Drew; Brautigam, Donald; Breton, Nicolas; Brouwers, P. J. A. M.; Browne, Kevin; Cortada, Jordi Bruguera; Bruni, A.; Brunschwig, Claude; Buathier, Hervé; Buhl, Aurélie; Bullinga, John; Cabrera, Jose Walter; Caccavo, Alberto; Cai, Shanglang; Caine, Sarah; Calò, Leonardo; Calvi, Valeria; Sánchez, Mauricio Camarillo; Candeias, Rui; Capuano, Vincenzo; Capucci, Alessandro; Caputo, Ronald; Rizo, Tatiana Cárdenas; Cardona, Francisco; da Costa Darrieux, Francisco Carlos; Vera, Yan Carlos Duarte; Carolei, Antonio; Carreño, Susana; Carvalho, Paula; Cary, Susanna; Casu, Gavino; Cavallini, Claudio; Cayla, Guillaume; Celentano, Aldo; Cha, Tae-Joon; Cha, Kwang Soo; Chae, Jei Keon; Chalamidas, Kathrine; Challappa, Krishnan; Chand, Sunil Prakash; Chandrashekar, Harinath; Chartier, Ludovic; Chatterjee, Kausik; Ayala, Carlos Antero Chavez; Cheema, Aamir; Cheema, Amjad; Chen, Lin; Chen, Shih-Ann; Chen, Jyh Hong; Chiang, Fu-Tien; Chiarella, Francesco; Chih-Chan, Lin; Cho, Yong Keun; Choi, Jong-Il; Choi, Dong Ju; Chouinard, Guy; Chow, Danny Hoi-Fan; Chrysos, Dimitrios; Chumakova, Galina; Valenzuela, Eduardo Julián José Roberto Chuquiu; Nica, Nicoleta Cindea; Cislowski, David J.; Clay, Anthony; Clifford, Piers; Cohen, Andrew; Cohen, Michael; Cohen, Serge; Colivicchi, Furio; Collins, Ronan; Colonna, Paolo; Compton, Steve; Connolly, Derek; Conti, Alberto; Buenostro, Gabriel Contreras; Coodley, Gregg; Cooper, Martin; Coronel, Julian; Corso, Giovanni; Sales, Juan Cosín; Cottin, Yves; Covalesky, John; Cracan, Aurel; Crea, Filippo; Crean, Peter; Crenshaw, James; Cullen, Tina; Darius, Harald; Dary, Patrick; Dascotte, Olivier; Dauber, Ira; Davalos, Vicente; Davies, Ruth; Davis, Gershan; Davy, Jean-Marc; Dayer, Mark; De Biasio, Marzia; De Bonis, Silvana; De Caterina, Raffaele; De Franceschi, Teresiano; de Groot, J. R.; De Horta, José; De La Briolle, Axel; de la Pena Topete, Gilberto; de Paola, Angelo Amato Vicenzo; de Souza, Weimar; de Veer, A.; De Wolf, Luc; Decoulx, Eric; Deepak, Sasalu; Defaye, Pascal; Munoz, Freddy Del-Carpio; Brkljacic, Diana Delic; Deumite, N. Joseph; Di Legge, Silvia; Diemberger, Igor; Dietz, Denise; Dionísio, Pedro; Dong, Qiang; dos Santos, Fabio Rossi; Dotcheva, Elena; Doukky, Rami; D'Souza, Anthony; Dubrey, Simon; Ducrocq, Xavier; Dupljakov, Dmitry; Duque, Mauricio; Dutta, Dipankar; Duvilla, Nathalie; Eaton; A. Duygun; Rainer Dziewas Charles B; Eaves, William; Ebels-Tuinbeek, L. A.; Ehrlich, Clifford; Eichinger-Hasenauer, Sabine; Eisenberg, Steven J.; Jabali, Adnan El; Shahawy, Mahfouz El; Hernandes, Mauro Esteves; Izal, Ana Etxeberria; Evonich, Rudolph; Evseeva, Oksana; Ezhov, Andrey; Fahmy, Raed; Fang, Quan; Farsad, Ramin; Fauchier, Laurent; Favale, Stefano; Fayard, Maxime; Fedele, Jose Luis; Fedele, Francesco; Fedorishina, Olga; Fera, Steven R.; Ferreira, Luis Gustavo Gomes; Ferreira, Jorge; Ferri, Claudio; Ferrier, Anna; Ferro, Hugo; Finsen, Alexandra; First, Brian; Fischer, Stuart; Fonseca, Catarina; Almeida, Luísa Fonseca; Forman, Steven; Frandsen, Brad; French, William; Friedman, Keith; Friese, Athena; Fruntelata, Ana Gabriela; Fujii, Shigeru; Fumagalli, Stefano; Fundamenski, Marta; Furukawa, Yutaka; Gabelmann, Matthias; Gabra, Nashwa; Gadsbøll, Niels; Galinier, Michel; Gammelgaard, Anders; Ganeshkumar, Priya; Gans, Christopher; Quintana, Antonio Garcia; Gartenlaub, Olivier; Gaspardone, Achille; Genz, Conrad; Georger, Frédéric; Georges, Jean-Louis; Georgeson, Steven; Giedrimas, Evaldas; Gierba, Mariusz; Ortega, Ignacio Gil; Gillespie, Eve; Giniger, Alberto; Giudici, Michael C.; Gkotsis, Alexandros; Glotzer, Taya V.; Gmehling, Joachim; Gniot, Jacek; Goethals, Peter; Goldbarg, Seth; Goldberg, Ronald; Goldmann, Britta; Golitsyn, Sergey; Gómez, Silvia; Mesa, Juan Gomez; Gonzalez, Vicente Bertomeu; Hermosillo, Jesus Antonio Gonzalez; López, Víctor Manuel González; Gorka, Hervé; Gornick, Charles; Gorog, Diana; Gottipaty, Venkat; Goube, Pascal; Goudevenos, Ioannis; Graham, Brett; Greer, G. Stephen; Gremmler, Uwe; Grena, Paul G.; Grond, Martin; Gronda, Edoardo; Grönefeld, Gerian; Gu, Xiang; Torres Torres, Ivett Guadalupe; Guardigli, Gabriele; Guevara, Carolina; Guignier, Alexandre; Gulizia, Michele; Gumbley, Michael; Günther, Albrecht; Ha, Andrew; Hahalis, Georgios; Hakas, Joseph; Hall, Christian; Han, Bing; Han, Seongwook; Hargrove, Joe; Hargroves, David; Harris, Kenneth B.; Haruna, Tetsuya; Hayek, Emil; Healey, Jeff; Hearne, Steven; Heffernan, Michael; Heggelund, Geir; Heijmeriks, J. A.; Hemels, Maarten; Hendriks, I.; Henein, Sam; Her, Sung-Ho; Hermany, Paul; Del Río, Jorge Eduardo Hernández; Higashino, Yorihiko; Hill, Michael; Hisadome, Tetsuo; Hishida, Eiji; Hoffer, Etienne; Hoghton, Matthew; Hong, Kui; Hong, Suk keun; Horbach, Stevie; Horiuchi, Masataka; Hou, Yinglong; Hsing, Jeff; Huang, Chi-Hung; Huckins, David; Hughes, kathy; Hung; A. Huizinga; E. L. Hulsman Kuo-Chun; Hwang, Gyo-Seung; Ikpoh, Margaret; Imberti, Davide; Ince, Hüseyin; Indolfi, Ciro; Inoue, Shujiro; Irles, Didier; Iseki, Harukazu; Israel, C. Noah; Iteld, Bruce; Iyer, Venkat; Jackson-Voyzey, Ewart; Jaffrani, Naseem; Jäger, Frank; James, Martin; Jang, Sung-Won; Jaramillo, Nicolas; Jarmukli, Nabil; Jeanfreau, Robert J.; Jenkins, Ronald D.; Sánchez, Carlos Jerjes; Jimenez, Javier; Jobe, Robert; Joen-Jakobsen, Tomas; Jones, Nicholas; Jorge, Jose Carlos Moura; Jouve, Bernard; Jung, Byung Chun; Jung, Kyung Tae; Jung, Werner; Kachkovskiy, Mikhail; Kafkala, Krystallenia; Kalinina, Larisa; Kallmünzer, Bernd; Kamali, Farzan; Kamo, Takehiro; Kampus, Priit; Kashou, Hisham; Kastrup, Andreas; Katsivas, Apostolos; Kaufman, Elizabeth; Kawai, Kazuya; Kawajiri, Kenji; Kazmierski, John F.; Keeling, P.; Saraiva, José Francisco Kerr; Ketova, Galina; Khaira, AJIT Singh; Khripun, Aleksey; Kim, Doo-Il; Kim, Young Hoon; Kim, Nam Ho; Kim, Dae Kyeong; Kim, Jeong Su; Kim, June Soo; Kim, Ki Seok; Kim, Jin bae; Kinova, Elena; Klein, Alexander; Kmetzo, James J.; Kneller, G. Larsen; Knezevic, Aleksandar; Koh, Su Mei Angela; Koide, Shunichi; Kollias, Anastasios; Kooistra, J. A.; Koons, Jay; Koschutnik, Martin; Kostis, William J.; Kovacic, Dragan; Kowalczyk, Jacek; Koziolova, Natalya; Kraft, Peter; Kragten, Johannes A.; Krantz, Mori; Krause, Lars; Krenning, B. J.; Krikke, F.; Kromhout, Z.; Krysiak, Waldemar; Kumar, Priya; Kümler, Thomas; Kuniss, Malte; Kuo, Jen-Yuan; Küppers, Achim; Kurrelmeyer, Karla; Kwak, Choong Hwan; Laboulle, Bénédicte; Labovitz, Arthur; Ter Lai, Wen; Lam, Andy; Lam, Yat Yin; Zanetti, Fernando Lanas; Landau, Charles; Landini, Giancarlo; Figueiredo, Estêvão Lanna; Larsen, Torben; Lavandier, Karine; LeBlanc, Jessica; Lee, Moon Hyoung; Lee, Chang-Hoon; Lehman, John; Leitão, Ana; Lellouche, Nicolas; Lelonek, Malgorzata; Lenarczyk, Radoslaw; Lenderink, T.; González, Salvador León; Leong-Sit, Peter; Leschke, Matthias; Ley, Nicolas; Li, Zhanquan; Li, Xiaodong; Li, Weihua; Li, Xiaoming; Lichy, Christhoh; Lieber, Ira; Rodriguez, Ramon Horacio Limon; Lin, Hailong; Liu, Feng; Liu, Hengliang; Esperon, Guillermo Llamas; Navarro, Nassip Llerena; Lo, Eric; Lokshyn, Sergiy; López, Amador; López-Sendón, José Luís; Filho, Adalberto Menezes Lorga; Lorraine, Richard S.; Luengas, Carlos Alberto; Luke, Robert; Luo, Ming; Lupovitch, Steven; Lyrer, Philippe; Ma, Changsheng; Ma, Genshan; Madariaga, Irene; Maeno, Koji; Magnin, Dominique; Maid, Gustavo; Mainigi, Sumeet K.; Makaritsis, Konstantinos; Malhotra, Rohit; Manning, Rickey; Manolis, Athanasios; Hurtado, Helard Andres Manrique; Mantas, Ioannis; Jattin, Fernando Manzur; Maqueda, Vicky; Marchionni, Niccolo; Ortuno, Francisco Marin; Santana, Antonio Martín; Martinez, Jorge; Maskova, Petra; Hernandez, Norberto Matadamas; Matsuda, Katsuhiro; Maurer, Tillmann; Mauro, Ciro; May, Erik; Mayer, Nolan; McClure, John; McCormack, Terry; McGarity, William; McIntyre, Hugh; McLaurin, Brent; Palomino, Feliz Alvaro Medina; Melandri, Francesco; Meno, Hiroshi; Menzies, Dhananjai; Mercader, Marco; Meyer, Christian; Meyer, Beat J.; Miarka, Jacek; Mibach, Frank; Michalski, Dominik; Michel, Patrik; Chreih, Rami Mihail; Mikdadi, Ghiath; Mikus, Milan; Milicic, Davor; Militaru, Constantin; Minaie, Sedi; Minescu, Bogdan; Mintale, Iveta; Mirault, Tristan; Mirro, Michael J.; Mistry, Dinesh; Miu, Nicoleta Violeta; Miyamoto, Naomasa; Moccetti, Tiziano; Mohammed, Akber; Nor, Azlisham Mohd; Mollerus, Michael; Molon, Giulio; Mondillo, Sergio; Moniz, Patrícia; Mont, Lluis; Montagud, Vicente; Montaña, Oscar; Monti, Cristina; Moretti, Luciano; Mori, Kiyoo; Moriarty, Andrew; Morka, Jacek; Moschini, Luigi; Moschos, Nikitas; Mügge, Andreas; Mulhearn, Thomas J.; Muresan, Carmen; Muriago, Michela; Musial, Wlodzimierz; Musser, Carl W.; Musumeci, Francesco; Nageh, Thuraia; Nakagawa, Hidemitsu; Nakamura, Yuichiro; Nakayama, Toru; Nam, Gi-Byoung; Nanna, Michele; Natarajan, Indira; Nayak, Hemal M.; Naydenov, Stefan; Nazlić, Jurica; Nechita, Alexandru Cristian; Nechvatal, Libor; Negron, Sandra Adela; Neiman, James; Neuenschwander, Fernando Carvalho; Neves, David; Neykova, Anna; Miguel, Ricardo Nicolás; Nijmeh, George; Nizov, Alexey; Campos, Rodrigo Noronha; Nossan, Janko; Novikova, Tatiana; Nowalany-Kozielska, Ewa; Nsah, Emmanuel; Fragoso, Juan Carlos Nunez; Nurgalieva, Svetlana; Nuyens, Dieter; Nyvad, Ole; de Los Rios Ibarra, Manuel Odin; O'Donnell, Philip; O'Donnell, Martin; Oh, Seil; Oh, Yong Seog; Oh, Dongjin; O'Hara, Gilles; Oikonomou, Kostas; Olivares, Claudia; Oliver, Richard; Ruiz, Rafael Olvera; Olympios, Christoforos; omaszuk-Kazberuk, Anna; Asensi, Joaquín Osca; jose, eena Padayattil; Padilla Padilla, Francisco Gerardo; Rios, Victoria Padilla; Pajes, Giuseppe; Pandey, A. Shekhar; Paparella, Gaetano; Paris, F.; Park, Hyung Wook; Park, Jong Sung; Parthenakis, Fragkiskos; Passamonti, Enrico; Patel, Rajesh J.; Patel, Jaydutt; Patel, Mehool; Patrick, Janice; Jimenez, Ricardo Pavón; Paz, Analía; Pengo, Vittorio; Pentz, William; Pérez, Beatriz; Ríos, Alma Minerva Pérez; Pérez-Cabezas, Alejandro; Perlman, Richard; Persic, Viktor; Perticone, Francesco; Peters, Terri K.; Petkar, Sanjiv; Pezo, Luis Felipe; Pflücke, Christian; Pham, David N.; Phillips, Roland T.; Phlaum, Stephen; Pieters, Denis; Pineau, Julien; Pinter, Arnold; Pinto, Fausto; Pisters, R.; Pivac, Nediljko; Pocanic, Darko; Podoleanu, Cristian; Politano, Alessandro; Poljakovic, Zdravka; Pollock, Stewart; Garcéa, Jose Polo; Poppert, Holger; Porcu, Maurizio; Reino, Antonio Pose; Prasad, Neeraj; Précoma, Dalton Bertolim; Prelle, Alessandro; Prodafikas, John; Protasov, Konstantin; Pye, Maurice; Qiu, Zhaohui; Quedillac, Jean-Michel; Raev, Dimitar; Grado, Carlos Antonio Raffo; Rahimi, Sidiqullah; Raisaro, Arturo; Rama, Bhola; Ramos, Ricardo; Ranieri, Maria; Raposo, Nuno; Rashba, Eric; Rauch-Kroehnert, Ursula; Reddy, Ramakota; Renda, Giulia; Reza, Shabbir; Ria, Luigi; Richter, Dimitrios; Rickli, Hans; Rieker, Werner; Vera, Tomas Ripolil; Ritt, Luiz Eduardo; Roberts, Douglas; Briones, Ignacio Rodriguez; Escudero, Aldo Edwin Rodriguez; Pascual, Carlos Rodríguez; Roman, Mark; Romeo, Francesco; Ronner, E.; Roux, Jean-Francois; Rozkova, Nadezda; Rubacek, Miroslav; Rubalcava, Frank; Russo, Andrea M.; Rutgers, Matthieu Pierre; Rybak, Karin; Said, Samir; Sakamoto, Tamotsu; Salacata, Abraham; Salem, Adrien; Bodes, Rafael Salguero; Saltzman, Marco A.; Salvioni, Alessandro; Vallejo, Gregorio Sanchez; Fernández, Marcelo Sanmartín; Saporito, Wladmir Faustino; Sarikonda, Kesari; Sasaoka, Taishi; Sati, Hamdi; Savelieva, Irina; Scala, Pierre-Jean; Schellinger, Peter; Scherr, Carlos; Schmitz, Lisa; Schmitz, Karl-Heinz; Schmitz, Bettina; Schnabel, Teresa; Schnupp, Steffen; Schoeniger, Peter; Schön, Norbert; Schwimmbeck, Peter; Seamark, Clare; Searles, Greg; Seidl, Karl-Heinz; Seidman, Barry; Sek, Jaroslaw; Sekaran, Lakshmanan; Serrati, Carlo; Shah, Neerav; Shah, Vinay; Shah, Anil; Shah, Shujahat; Sharma, Vijay Kumar; Shaw, Louise; Sheikh, Khalid H.; Shimizu, Naruhito; Shimomura, Hideki; Shin, Dong-Gu; Shin, Eun-Seok; Shite, Junya; Sibilio, Gerolamo; Silver, Frank; Sime, Iveta; Simmers, Tim A.; Singh, Narendra; Siostrzonek, Peter; Smadja, Didier; Smith, David W.; Snitman, Marcelo; Filho, Dario Sobral; Soda, Hassan; Sofley, Carl; Sokal, Adam; Yan, Yannie Soo Oi; Sotolongo, Rodolfo; de Souza, Olga Ferreira; Sparby, Jon Arne; Spinar, Jindrich; Sprigings, David; Spyropoulos, Alex C.; Stakos, Dimitrios; Steinwender, Clemens; Stergiou, Georgios; Stiell, Ian; Stoddard, Marcus; Stoikov, Anastas; Streb, Witold; Styliadis, Ioannis; Su, Guohai; Su, Xi; Sudnik, Wanda; Sukles, Kai; Sun, Xiaofei; Swart, H.; Szavits-Nossan, Janko; Taggeselle, Jens; Takagi, Yuichiro; Takhar, Amrit Pal Singh; Tamm, Angelika; Tanaka, Katsumi; Tanawuttiwat, Tanyanan; Tang, Sherman; Tang, Aylmer; Tarsi, Giovanni; Tassinari, Tiziana; Tayal, Ashis; Tayebjee, Muzahir; Berg, J. M. ten; Tesloianu, Dan; The, Salem H. K.; Thomas, Dierk; Timsit, Serge; Tobaru, Tetsuya; Tomasik. , Andrzej R.; Torosoff, Mikhail; Touze, Emmanuel; Trendafilova, Elina; Tsai, W. Kevin; Tse, Hung Fat; Tsutsui, Hiroshi; Tu, Tian Ming; Tuininga, Ype; Turakhia, Minang; Turk, Samir; Turner, Wayne; Tveit, Arnljot; Tytus, Richard; Valadão, C.; van Bergen, P. F. M. M.; van de Borne, Philippe; van den Berg, B. J.; van der Zwaan, C.; Van Eck, M.; Vanacker, Peter; Vasilev, Dimo; Vasilikos, Vasileios; Vasilyev, Maxim; Veerareddy, Srikar; Miño, Mario Vega; Venkataraman, Asok; Verdecchia, Paolo; Versaci, Francesco; Vester, Ernst Günter; Vial, Hubert; Victory, Jason; Villamil, Alejandro; Vincent, Marc; Vlastaris, Anthony; Dahl, Jürgen vom; Vora, Kishor; Vranian, Robert B.; Wakefield, Paul; Wang, Ningfu; Wang, Mingsheng; Wang, Xinhua; Wang, Feng; Wang, Tian; Warner, Alberta L.; Watanabe, Kouki; Wei, Jeanne; Weimar, Christian; Weiner, Stanislav; Weinrich, Renate; Wen, Ming-Shien; Wiemer, Marcus; Wiggers, Preben; Wilke, Andreas; Williams, David; Williams, Marcus L.; Witzenbichler, Bernhard; Wong, Brian; Wong, Ka Sing Lawrence; Wozakowska-Kaplon, Beata; Wu, Shulin; Wu, Richard C.; Wunderlich, Silke; Wyatt, Nell; Wylie, John; Xu, Yong; Xu, Xiangdong; Yamanoue, Hiroki; Yamashita, Takeshi; Yan, Ping Yen Bryan; Yang, Tianlun; Yao, Jing; Yeh, Kuo-Ho; Yin, Wei Hsian; Yotov, Yoto; Zahn, Ralf; Zarich, Stuart; Zenin, Sergei; Zeuthen, Elisabeth Louise; Zhang, Huanyi; Zhang, Donghui; Zhang, Xingwei; Zhang, Ping; Zhang, Jun; Zhao, Shui Ping; Zhao, Yujie; Zhao, Zhichen; Zheng, Yang; Zhou, Jing; Zimmermann, Sergio; Zini, Andrea; Zizzo, Steven; Zong, Wenxia; Steven Zukerman, L.; null, null
Contributors:	W.Y. Ding; A.M. Fawzy; G.F. Romiti; M. Proietti; D. Pastori; M.V. Huisman; G.Y.H. Lip; D.W. Abban; N. Abdul; A.M. Abud; F. Adam; S. Addala; P. Adragão; W. Ageno; R. Aggarwal; S. Agosti; P. Agostoni; F. Aguilar; J.A. Linare; L. Aguinaga; J. Ahmed; A. Aiello; P. Ainsworth; J.R. Aiub; R. Al-Dallow; L. Alderson; J.A.A. Velasco; D. Alexopoulo; F.A. Manterola; P. Aliyar; D. Alonso; F.A.A. da Costa; J. Amado; W. Amara; M. Amelot; N. Amjadi; F. Ammirati; M. Andrade; N. Andrawi; G. Annoni; G. Ansalone; M.K. Ariani; J.C. Aria; S. Armero; C. Arora; M.S. Aslam; M. Asselman; P. Audouin; C. Augenbraun; S. Aydin; I. Ayryanova; E. Aziz; L.M. Backe; E. Bading; E. Bagni; S.H. Baker; R. Bala; A. Baldi; S. Bando; S. Banerjee; A. Bank; G.B. Esquivia; C. Barr; M. Bartlett; V.B. Ke; G. Baula; S. Behren; A. Bell; R. Benedetti; J.B. Mazueco; B. Benhalima; J. Bergler-Klein; J. Berneau; P. Berrospi; S. Berti; A. Berz; E. Best; P. Bettencourt; R. Betzu; R. Bhagwat; L. Bhatta; F. Biscione; G. Bisignani; T. Black; M.J. Bloch; S. Bloom; E. Blumberg; M. Bo; E. Bøhmer; A. Bollmann; M.G. Bongiorni; G. Boriani; D.J. Boswijk; J. Bott; E. Bottacchi; M.B. Kalan; D. Bradman; D. Brautigam; N. Breton; P.J.A.M. Brouwer
Publisher Information:	Springer Nature
Publication Year:	2024
Collection:	The University of Milan: Archivio Istituzionale della Ricerca (AIR)
Subject Terms:	Atrial fibrillation; Cardiovascular mortality; Myocardial infarction; Risk stratification; Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Description:	The 2MACE score was specifically developed as a risk-stratification tool in atrial fibrillation (AF) to predict cardiovascular outcomes. We evaluated the predictive ability of the 2MACE score in the GLORIA-AF registry. All eligible patients from phase II/III of the prospective global GLORIA-AF registry were included. Major adverse cardiac events (MACEs) were defined as the composite outcome of stroke, myocardial infarction and cardiovascular death. Cox proportional hazards were used to examine the relationship between the 2MACE score and study outcomes. Predictive capability of the 2MACE score was investigated using receiver-operating characteristic curves. A total of 25,696 patients were included (mean age 71 years, female 44.9%). Over 3 years, 1583 MACEs were recorded. Patients who had MACE were older, with more cardiovascular risk factors and were less likely to be managed using a rhythm-control strategy. The median 2MACE score in the MACE and non-MACE groups were 2 (IQR 1-3) and 1 (IQR 0-2), respectively (p < 0.001). The 2MACE score was positively associated with an increase in the risk of MACE, with a score of ≥ 2 providing the best combination of sensitivity (69.6%) and specificity (51.6%), HR 2.47 (95% CI, 2.21-2.77). The 2MACE score had modest predictive performance for MACE in patients with AF (AUC 0.655 (95% CI, 0.641-0.669)). Our analysis in this prospective global registry demonstrates that the 2MACE score can adequately predict the risk of MACE (defined as myocardial infarction, CV death and stroke) in patients with AF. Clinical trial registration: http://www.clinicaltrials.gov . Unique identifiers: NCT01468701, NCT01671007 and NCT01937377.
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/37566295; info:eu-repo/semantics/altIdentifier/wos/WOS:001047277000001; volume:57; issue:1; firstpage:39; lastpage:49; numberofpages:11; journal:JOURNAL OF THROMBOSIS AND THROMBOLYSIS; https://hdl.handle.net/2434/1066009
DOI:	10.1007/s11239-023-02866-y
Availability:	https://hdl.handle.net/2434/1066009; https://doi.org/10.1007/s11239-023-02866-y
Rights:	info:eu-repo/semantics/openAccess
Accession Number:	edsbas.D8FD49FF
Database:	BASE