| Title: |
The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis? |
| Authors: |
De Simone, Belinda; Abu-Zidan, Fikri M.; Kluger, Yoram; Cappato, S; Muzio, E; Colak, E; Polat, S; Koylu, ZA; Altintoprak, F; Bayhan, Z; Akin, E; Andolfi, E; Rezart, S; Coccolini, Federico; Il Kim, J; Jung, SW; Shin, YC; Enciu, O; Toma, EA; Medas, F; Canu, GL; Cappellacci, F; d'Acapito, F; Ercolani, G; Landaluce-Olavarria, Aitor; Solaini, L; Roscio, F; Clerici, F; Gelmini, R; Serra, F; Rossi, EG; Fleres, F; Clarizia, G; Spolini, A; Ferrara, F; Estraviz-Mateos, Begona; Nita, G; Sarnari, J; Gachabayov, M; Abdullaev, A; Poillucci, G; Palini, GM; Veneroni, S; Garulli, G; Piccoli, M; Pattacini, GC; Uriguen-Etxeberria, Ana; Pecchini, F; Argenio, G; Armellino, MF; Brisinda, G; Tedesco, S; Fransvea, P; Ietto, G; Franchi, C; Carcano, G; Martines, G; Giordano, Alessio; Trigiante, G; Negro, G; Vega, GM; Gonzalez, AR; Ojeda, L; Piccolo, G; Bondurri, A; Maffioli, A; Guerci, C; Sin, BH; Luna, Alfonso Palmieri; Zuhdi, Z; Azman, A; Mousa, H; Al Bahri, S; Augustin, G; Romic, I; Moric, T; Nikolopoulos, I; Andreuccetti, J; Pignata, G; Amin, Luz Adriana Hernandez; D'Alessio, R; Kenig, J; Skorus, U; Fraga, GP; Hirano, ES; Bertuol, JVDL; Isik, A; Kurnaz, E; Asghar, MS; Afzal, A; Hernandez, Adriana Maria Palmieri; Akbar, A; Nikolouzakis, TK; Lasithiotakis, K; Chrysos, E; Das, K; Ozer, N; Seker, A; Ibrahim, M; Hamid, HKS; Babiker, A; Shabana, Amanda; Bouliaris, K; Koukoulis, G; Kolla, C-C; Lucchi, A; Agostinelli, L; Taddei, A; Fortuna, L; Agostini, C; Licari, L; Viola, S; Chouillard, Elie; Dzulkarnaen, Zakaria Andee; Callari, C; Laface, L; Abate, E; Casati, M; Anastasi, A; Canonico, G; Gabellini, L; Tosi, L; Guariniello, A; Zanzi, F; Othman, MA; Bains, L; Sydorchuk, L; Iftoda, O; Sydorchuk, A; Malerba, M; Costanzo, F; Galleano, R; Monteleone, M; Costanzi, A; Riva, C; Sani, MI; Waledziak, M; Kwiatkowski, A; Czyzykowski, L; Major, P; Strzalka, M; Matyja, M; Natkaniec, M; Valenti, MR; Di Vita, MDP; Sotiropoulou, M; Balla, A; Kapiris, S; Massalou, D; Veroux, M; Volpicelli, A; Gioco, R; Uccelli, M; Bonaldi, M; Olmi, S; Nardi, M; Livadoti, G; Scaramuzzo, R; Mesina, C; Dumitrescu, TV; Ciorbagiu, MC; Ammendola, M; Ammerata, G; Romano, R; Slavchev, M; Misiakos, EP; Pikoulis, E; Papaconstantinou, D; Lepiane, P; Elbahnasawy, M; Abdel-Elsalam, S; Felsenreich, DM; Jedamzik, J; Michalopoulos, N; Sidiropoulos, TA; Papadoliopoulou, M; Cillara, N; Deserra, A; Cannavera, A; Bottari, A; Negoi, I; Schizas, D; Syllaios, A; Vagios, I; Gourgiotis, S; Dai, N; Gurung, R; Norrey, M; Pesce, A; Feo, CV; Staderini, F; Fabbri, N; Machairas, N; Dorovinis, P; Keramida, MD; Mulita, F; Verras, GI; Vailas, M; Yalkin, O; Iflazoglu, N; Yigit, D; Cianchi, F; Baraket, O; Ayed, K; Ghalloussi, MH; Patias, P; Ntokos, G; Rahim, R; Bala, M; Kedar, A; Sawyer, RG; Trinh, A; Cavallaro, A; Miller, K; Sydorchuk, R; Knut, R; Plehutsa, O; Liman, RK; Ozkan, Z; Kader, SA; Gupta, S; Gureh, M; Saeidi, S; Di Saverio, Salomone; Zanghi, A; Aliakbarian, M; Dalili, A; Shoko, T; Kojima, M; Nakamoto, R; Atici, SD; Tuncer, GK; Kaya, T; Delis, SG; Rossi, S; Cappellani, A; Picardi, B; Del Monte, SR; Triantafyllou, T; Theodorou, D; Pintar, T; Salobir, J; Manatakis, DK; Tasis, N; Acheimastos, V; Ioannidis, O; Campagnacci, R; Loutzidou, L; Symeonidis, S; de Sa, TC; Rocha, M; Guagni, T; Pantalone, D; Maltinti, G; Khokha, V; Abdel-Elsalam, W; Ghoneim, B; Maurizi, A; Lopez-Ruiz, JA; Kara, Y; Zainudin, S; Hayati, F; Azizan, N; Khei, VTP; Yi, RCX; Sellappan, H; Demetrashvili, Z; Lekiashvili, N; Martinotti, M; Tvaladze, A; Froiio, C; Bernardi, D; Bonavina, L; Gil-Olarte, A; Grassia, S; Romero-Vargas, E; Bianco, F; Gumbs, AA; Dogjani, A; Ruggieri, A; Agresta, F; Litvin, A; Balogh, Zsolt J.; Gendrikson, G; Martino, C; Damaskos, D; Pararas, N; Kirkpatrick, A; Kurtenkov, M; Gomes, FC; Jusoh, AC; Pisanu, A; Nardello, O; Gambarini, F; Aref, H; de'Angelis, N; Agnoletti, V; Biondi, A; Vacante, M; Griggio, G; Tutino, R; Rahman, KA; Massani, M; Bisetto, G; Occhionorelli, S; Andreotti, D; Lacavalla, D; Biffl, WL; Catena, F; Zulkifli, ASM; Petronio, B; Sartelli, Massimo; Matias-Garcia, B; Quiroga-Valcarcel, A; Mendoza-Moreno, F; Atanasov, B; Campanile, FC; Vecchioni, I; Cardinali, L; Travaglini, G; Sebastiani, E; Chooklin, S; Podda, Mauro; Chuklin, S; Cianci, P; Restini, E; Capuzzolo, S; Curro, G; Filippo, R; Rispoli, M; Aparicio-Sanchez, D; Munoz-Cruzado, VD; Barbeito, SD; Gomes, Carlos Augusto; Delibegovic, S; Kesetovic, A; Sasia, D; Borghi, F; Giraudo, G; Visconti, D; Doria, E; Santarelli, M; Luppi, D; Bonilauri, S; Moore, Ernest E.; Grossi, U; Zanus, G; Sartori, A; Piatto, G; De Luca, M; Vita, D; Conti, L; Capelli, P; Cattaneo, GM; Marinis, A; Moug, Susan J.; Vederaki, S-A; Bayrak, M; Altintas, Y; Uzunoglu, MY; Demirbas, IE; Altinel, Y; Meric, S; Aktimur, YE; Uymaz, DS; Omarov, N; Ansaloni, Luca; Azamat, I; Lostoridis, E; Nagorni, E-A; Pujante, A; Anania, G; Bombardini, C; Bagolini, F; Gonullu, E; Mantoglu, B; Capoglu, R |
| Contributors: |
The University of Newcastle. College of Health, Medicine & Wellbeing, School of Medicine and Public Health |
| Publisher Information: |
BioMed Central Ltd. |
| Publication Year: |
2022 |
| Collection: |
NOVA: The University of Newcastle Research Online (Australia) |
| Subject Terms: |
acute cholecystitis; cholecystectomy; gangrene; COVID-19; SARS-CoV-2; laparoscopy; SDG 3; Sustainable Development Goals |
| Description: |
Background: The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods: Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results: A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions: The incidence ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
World Journal of Emergency Surgery Vol. 17, no. 61; http://hdl.handle.net/1959.13/1490427; uon:52904 |
| Availability: |
http://hdl.handle.net/1959.13/1490427 |
| Accession Number: |
edsbas.D8FD66CF |
| Database: |
BASE |