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Features of the gut microbiota in children with chronic liver diseases ; Особенности кишечной микробиоты у детей с хроническими заболеваниями печени

Title: Features of the gut microbiota in children with chronic liver diseases ; Особенности кишечной микробиоты у детей с хроническими заболеваниями печени
Authors: G. V. Volynets; A. S. Potapov; A. V. Nikitin; L. G. Danilov; T. A. Skvortsova; V. V. Dudurich; Г. В. Волынец; А. С. Потапов; А. В. Никитин; Л. Г. Данилов; Т. А. Скворцова; В. В. Дудурич
Source: Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics); Том 68, № 4 (2023); 66-76 ; Российский вестник перинатологии и педиатрии; Том 68, № 4 (2023); 66-76 ; 2500-2228 ; 1027-4065
Publisher Information: Ltd. “The National Academy of Pediatric Science and Innovation”
Publication Year: 2023
Collection: Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) / Российский вестник перинатологии и педиатрии
Subject Terms: иммуносупрессивная терапия; intestinal microbiota; chronic liver disease; autoimmune liver disease; non-autoimmune liver disease; immunosuppressive therapy; кишечная микробиота; хронические болезни печени; аутоиммунные болезни печени; неаутоиммунные болезни печени
Description: The value of the liver–gut axis is increasingly recognized as a major modulator of autoimmunity. There is no comparative analysis of data on the taxonomic diversity of the intestinal microbiota in chronic liver diseases in children. Purpose. To investigate the taxonomic diversity of the intestinal microbiota in children with chronic liver diseases compared with healthy patients, to identify differences in bacterial diversity in autoimmune and non-autoimmune liver diseases, as well as the impact of immunosuppressive therapy on the intestinal microbiota. Material and methods. A metagenomic analysis of the gut microbiota of 24 children with chronic liver diseases (mean age 10,3 ± 4,7 years) was carried out with the identification of the V3–V4 region of the 16S rRNA gene. The group included 18 children with autoimmune liver diseases and 6 children with non-autoimmune liver diseases. The control group consisted of fecal samples of 34 apparently healthy children. Results. When comparing fecal samples of children with autoimmune liver diseases with samples of healthy children, the taxa of Bacteroides dorei, Collinsella aerofaciens, Ruminococcus caffidurs prevailed, and for children of the control group — Neisseria flavescens. When comparing samples of patients with non-autoimmune liver diseases and the control group, it was found that the taxa Bacteroides fragilis, Klebsiella pneumoniae, Bifidobacterium longum prevailed in healthy children. When comparing fecal samples from children with autoimmune and non-autoimmune liver diseases, it was found that Veillonella dispar, Cloacibacillus porcorum, Veillonella parvula, Prevotella histicola and Bacteroides eggerthii taxa dominate in patients with non-autoimmune diseases. No dominant taxa of the gut microbiota were found in children with autoimmune liver diseases. It has been established that the taxa Veillonella dispar, Faecalibacterium prausnitzii, Roseburia inulinivorans, Bacteroides xylanisolvens and Alistipes obesi prevail in patients receiving immunosuppressive ...
Document Type: article in journal/newspaper
File Description: application/pdf
Language: Russian
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DOI: 10.21508/1027-4065-66-XX
Availability: https://www.ped-perinatology.ru/jour/article/view/1850; https://doi.org/10.21508/1027-4065-66-XX
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Accession Number: edsbas.D8FF8D7B
Database: BASE