| Title: |
Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery |
| Authors: |
Bernard, Arnaud; Richard, Corentin; Radoï, Loredana; Boidot, Romain; Ledoux, Séverine; Besnard, Philippe |
| Contributors: |
Center for Translational and Molecular medicine Dijon - UMR1231 (CTM); École Pratique des Hautes Études (EPHE); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon; Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université Bourgogne Europe (UBE); Département de Biologie et pathologie des tumeurs Centre Georges-François Leclerc; Centre Régional de Lutte contre le cancer Georges-François Leclerc Dijon (UNICANCER/CRLCC-CGFL); UNICANCER-UNICANCER; Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); The HumanFATaste2 program from which this study is derived wassupported by a grant from the French National Research Agencyunder the program “Investissements d’avenir” and by financial sup-ports from the Lesieur/Avril group, Tereos company, and the Benja-min Delessert Institute; ANR-11-LABX-0021,Lipstic,Lipoprotéines et santé : prévention et traitement des maladies inflammatoires non vasculaires et du cancer(2011) |
| Source: |
ISSN: 1930-7381 ; Obesity ; https://institut-agro-dijon.hal.science/hal-05157446 ; Obesity, 2025, pp.1-11. ⟨10.1002/oby.24325⟩. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2025 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
Orosensory Detection; Receptor; Acids; [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition; [SDV.BBM]Life Sciences [q-bio]/Biochemistry; Molecular Biology |
| Description: |
International audience ; Objective Fat taste sensitivity has been implicated in long-term weight loss after bariatric surgery. Unexpectedly, improvement of orosensory fat acuity was not systematic in operated patients.MethodsObesity-induced alterations of gene expression in gustatory papillae having been recently reported, we have explored the fungiform transcriptomic activity in the bariatric surgery context. Fat taste detection thresholds (three-alternative ascending forced-choice tests) alongside transcriptomic profiling of freshly isolated fungiform papillae were assessed in women with severe obesity before and 6 months after sleeve gastrectomy.ResultsAccording to evolution of post surgery detection thresholds, lipid-improved and -unimproved subgroups were identified, despite similar initial anthropometric parameters. Lower weight loss and higher plasma fasting insulin, C-reactive protein, and fibrinogen levels distinguished lipid-unimproved patients. This subgroup also overexpressed genes involved in inflammation and apoptosis, with certain ones being positively correlated with high lipid detection thresholds (low sensitivity), whereas the key gene of taste bud cell signaling, TRPM5, was down-expressed. In lipid-improved patients, genes implicated in cell renewal, neuronal function, and receptor recycling were upregulated and associated with better lipid detection efficiency. Pathway enrichment identified immune and anti-inflammatory activities in lipid-unimproved and -improved groups, respectively.ConclusionsThese findings collectively suggest that changes in gene expression within gustatory papillae contribute to fat taste sensitivity after sleeve gastrectomy. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/oby.24325 |
| Availability: |
https://institut-agro-dijon.hal.science/hal-05157446; https://institut-agro-dijon.hal.science/hal-05157446v1/document; https://institut-agro-dijon.hal.science/hal-05157446v1/file/Obesity%20-%202025%20-%20Bernard%20-%20Fat%20taste%20sensitivity%20in%20women%20with%20obesity%20%20transcriptomic%20analysis%20of%20fungiform%20papillae.pdf; https://doi.org/10.1002/oby.24325 |
| Rights: |
http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.D95B264F |
| Database: |
BASE |