| Title: |
Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals |
| Authors: |
Schmidt, Matthieu; Demoule, Alexandre; Hajage, David; Pham, Tài; Combes, Alain; Dres, Martin; Lebbah, Said; Kimmoun, Antoine; Mercat, Alain; Beduneau, Gaëtan; Palmyre, Jessica; Prevost, Margot; Ricard, Jean-Damien; Ferré, Alexis; Fayolle, Pierre-Marie; Girault, Christophe; Pradel, Gael; Asfar, Pierre; Beloncle, François; Demiselle, Julien; Pavot, Arthur; Monnet, Xavier; Richard, Christian; Mayaux, Julien; Beurton, Alexandra; Daubin, Cédric; Descamps, Richard; Joret, Aurélie; Du Cheyron, Damien; Pene, Frédéric; Chiche, Jean-Daniel; Jozwiak, Mathieu; Jaubert, Paul; Voiriot, Guillaume; Fartoukh, Muriel; Teulier, Marion; Blayau, Clarisse; L’her, Erwen; Aubron, Cécile; Bodenes, Laetitia; Ferriere, Nicolas; Auchabie, Johann; Le Meur, Anthony; Pignal, Sylvain; Mazzoni, Thierry; Quenot, Jean-Pierre; Andreu, Pascal; Roudau, Jean-Baptiste; Labruyère, Marie; Nseir, Saad; Preau, Sébastien; Poissy, Julien; Mathieu, Daniel; Benhamida, Sarah; Paulet, Rémi; Roucaud, Nicolas; Thyrault, Martial; Daviet, Florence; Hraiech, Sami; Parzy, Gabriel; Sylvestre, Aude; Jochmans, Sébastien; Bouilland, Anne-Laure; Monchi, Mehran; Des Déserts, Marc Danguy; Mathais, Quentin; Rager, Gwendoline; Pasquier, Pierre; Jean, Reignier; Amélie, Seguin; Charlotte, Garret; Emmanuel, Canet; Dellamonica, Jean; Saccheri, Clément; Lombardi, Romain; Kouchit, Yanis; Jacquier, Sophie; Mathonnet, Armelle; Nay, Mai-Ahn; Runge, Isabelle; Martino, Frédéric; Flurin, Laure; Rolle, Amélie; Carles, Michel; Coudroy, Rémi; Thille, Arnaud; Frat, Jean-Pierre; Rodriguez, Maeva; Beuret, Pascal; Tientcheu, Audrey; Vincent, Arthur; Michelin, Florian; Tamion, Fabienne; Carpentier, Dorothée; Boyer, Déborah; Gissot, Valérie; Ehrmann, Stéphan; Gandonniere, Charlotte Salmon; Elaroussi, Djlali; Delbove, Agathe; Fedun, Yannick; Huntzinger, Julien; Lebas, Eddy; Kisoka, Grâce; Grégoire, Céline; Marchetta, Stella; Lambermont, Bernard; Argaud, Laurent; Baudry, Thomas; Bertrand, Pierre-Jean; Dargent, Auguste; Guitton, Christophe; Chudeau, Nicolas; Landais, Mickaël; Darreau, Cédric; Ferre, Alexis; Gros, Antoine; Lacave, Guillaume; Bruneel, Fabrice; Neuville, Mathilde; Devaquet, Jérôme; Tachon, Guillaume; Gallot, Richard; Chelha, Riad; Galbois, Arnaud; Jallot, Anne; Lemoine, Ludivine Chalumeau; Kuteifan, Khaldoun; Pointurier, Valentin; Jandeaux, Louise-Marie; Mootien, Joy; Damoisel, Charles; Sztrymf, Benjamin; Chommeloux, Juliette; Luyt, Charles Edouard; Schortgen, Frédérique; Rusel, Leon; Jung, Camille; Gobert, Florent; Vimpere, Damien; Lamhaut, Lionel; Sauneuf, Bertrand; Charrrier, Liliane; Calus, Julien; Desmeules, Isabelle; Painvin, Benoît; Tadie, Jean-Marc; Castelain, Vincent; Michard, Baptiste; Herbrecht, Jean-Etienne; Baldacini, Mathieu; Weiss, Nicolas; Demeret, Sophie; Marois, Clémence; Rohaut, Benjamin; Moury, Pierre-Henri; Savida, Anne-Charlotte; Couadau, Emmanuel; Série, Mathieu; Alexandru, Nica; Bruel, Cédric; Fontaine, Candice; Garrigou, Sonia; Mahler, Juliette Courtiade; Leclerc, Maxime; Ramakers, Michel; Garçon, Pierre; Massou, Nicole; van Vong, Ly; Sen, Juliane; Lucas, Nolwenn; Chemouni, Franck; Stoclin, Annabelle; Avenel, Alexandre; Faure, Henri; Gentilhomme, Angélie; Ricome, Sylvie; Abraham, Paul; Monard, Céline; Textoris, Julien; Rimmele, Thomas; Montini, Florent; Lejour, Gabriel; Lazard, Thierry; Etienney, Isabelle; Kerroumi, Younes; Dupuis, Claire; Bereiziat, Marine; Coupez, Elisabeth; Thouy, François; Hoffmann, Clément; Donat, Nicolas; Chrisment, Anne; Blot, Rose-Marie; Jacquot, Audrey; Mattei, Matthieu; Levy, Bruno; Ravan, Ramin; Dopeux, Loïc; Liteaudon, Jean-Mathias; Roux, Delphine; Rey, Brice; Anghel, Radu; Schenesse, Deborah; Gevrey, Vincent; Castanera, Jermy; Petua, Philippe; Madeux, Benjamin; Hartman, Otto; Piagnerelli, Michael; Joosten, Anne; Noel, Cinderella; Biston, Patrick; Noel, Thibaut; Bouar, Gurvan; Boukhanza, Messabi; Demarest, Elsa; Bajolet, Marie-France; Charrier, Nathanaël; Quenet, Audrey; Zylberfajn, Cécile; Dufour, Nicolas; Mégarbane, Buno; Voicu, Sqébastian; Deye, Nicolas; Malissin, Isabelle; Legay, François; Debarre, Matthieu; Barbarot, Nicolas; Fillatre, Pierre; Delord, Bertrand; Laterrade, Thomas; Saghi, Tahar; Pujol, Wilfried; Cungi, Pierre Julien; Esnault, Pierre; Cardinale, Mickael; Ha, Vivien Hong Tuan; Fleury, Grégory; Brou, Marie-Ange; Zafimahazo, Daniel; Tran-Van, David; Avargues, Patrick; Carenco, Lisa; Robin, Nicolas; Ouali, Alexandre; Houdou, Lucie; Le Terrier, Christophe; Suh, Noémie; Primmaz, Steve; Pugin, Jérome; Weiss, Emmanuel; Gauss, Tobias; Moyer, Jean-Denis; Burtz, Catherine Paugam; La Combe, Béatrice; Smonig, Rolland; Violleau, Jade; Cailliez, Pauline; Chelly, Jonathan; Marchalot, Antoine; Saladin, Cécile; Bigot, Christelle; Fatséas, Jules; Ibrahim, Amr; Resiere, Dabor; Hage, Rabih; Cholet, Clémentine; Cantier, Marie; Trouiler, Pierre; Montravers, Philippe; Lortat-Jacob, Brice; Tanaka, Sebastien; Dinh, Alexy Tran; Duranteau, Jacques; Harrois, Anatole; Dubreuil, Guillaume; Werner, Marie; Godier, Anne; Hamada, Sophie; Zlotnik, Diane; Nougue, Hélène; Mekontso-Dessap, Armand; Carteaux, Guillaume; Razazi, Keyvan; de Prost, Nicolas; Mongardon, Nicolas; Langeron, Olivier; Levesque, Eric; Attias, Arié; de Roquetaillade, Charles; Chousterman, Benjamin; Mebazaa, Alexandre; Gayat, Etienne; Garnier, Marc; Pardo, Emmanuel; Satre-Buisson, Lea; Gutton, Christophe; Yvin, Elise; Marcault, Clémence; Azoulay, Elie; Darmon, Michael; Oufella, Hafid Ait; Hariri, Geoffroy; Urbina, Tomas; Mazerand, Sandie; Heming, Nicholas; Santi, Francesca; Moine, Pierre; Annane, Djillali; Bouglé, Adrien; Omar, Edris; Lancelot, Aymeric; Begot, Emmanuelle; Plantefeve, Gaétan; Contou, Damien; Mentec, Hervé; Pajot, Olivier; Faguer, Stanislas; Cointault, Olivier; Lavayssiere, Laurence; Nogier, Marie-Béatrice; Jamme, Matthieu; Pichereau, Claire; Hayon, Jan; Outin, Hervé; Dépret, François; Coutrot, Maxime; Chaussard, Maité; Guillemet, Lucie; Goffin, Pierre; Thouny, Romain; Guntz, Julien; Jadot, Laurent; Persichini, Romain; Jean-Michel, Vanessa; Georges, Hugues; Caulier, Thomas; Pradel, Gaël; Hausermann, Marie-Hélène; Nguyen-Valat, Thi My Hue; Boudinaud, Michel; Vivier, Emmanuel; Rosseli, Sylvène; Bourdin, Gaël; Pommier, Christian; Vinclair, Marc; Poignant, Simon; Mons, Sandrine; Bougouin, Wulfran; Bruna, Franklin; Maestraggi, Quentin; Roth, Christian; Bitker, Laurent; Dhelft, François; Bonnet-Chateau, Justine; Filippelli, Mathilde; Morichau-Beauchant, Tristan; Thierry, Stéphane; Le Roy, Charlotte; Jouan, Mélanie Saint; Goncalves, Bruno; Mazeraud, Aurélien; Daniel, Matthieu; Sharshar, Tarek; Cadoz, Cyril; Gaci, Rostane; Gette, Sébastien; Louis, Guillaune; Sacleux, Sophe-Caroline; Ordan, Marie-Amélie; Cravoisy, Aurélie; Conrad, Marie; Courte, Guilhem; Gibot, Sébastien; Benzidi, Younès; Casella, Claudia; Serpin, Laurent; Setti, Jean-Lou; Besse, Marie-Catherine; Bourreau, Anna; Pillot, Jérôme; Rivera, Caroline; Vinclair, Camille; Robaux, Marie-Aline; Achino, Chloé; Delignette, Marie-Charlotte; Mazard, Tessa; Aubrun, Frédéric; Bouchet, Bruno; Frérou, Aurélien; Muller, Laura; Quentin, Charlotte; Degoul, Samuel; Stihle, Xavier; Sumian, Claude; Bergero, Nicoletta; Lanaspre, Bernard; Quintard, Hervé; Maiziere, Eve Marie; Egreteau, Pierre-Yves; Leloup, Guillaume; Berteau, Florin; Cottrel, Marjolaine; Bouteloup, Marie; Jeannot, Matthieu; Blanc, Quentin; Saison, Julien; Geneau, Isabelle; Grenot, Romaric; Ouchike, Abdel; Hazera, Pascal; Masse, Anne-Lyse; Demiri, Suela; Vezinet, Corinne; Baron, Elodie; Benchetrit, Deborah; Monsel, Antoine; Trebbia, Grégoire; Schaack, Emmanuelle; Lepecq, Raphaël; Bobet, Mathieu; Vinsonneau, Christophe; Dekeyser, Thibault; Delforge, Quentin; Rahmani, Imen; Vivet, Bérengère; Paillot, Jonathan; Hierle, Lucie; Chaignat, Claire; Valette, Sarah; Her, Benoït; Brunet, Jennifier; Page, Mathieu; Boiste, Fabienne; Collin, Anthony; Bavozet, Florent; Garin, Aude; Dlala, Mohamed; Mhamdi, Kais; Beilouny, Bassem; Lavalard, Alexandra; Perez, Severine; Veber, Benoit; Guitard, Pierre-Gildas; Gouin, Philippe; Lamacz, Anna; Plouvier, Fabienne; Delaborde, Bertrand; Kherchache, Aïssa; Chaalal, Amina; Amouretti, Marc; Freita-Ramos, Santiago; Roux, Damien; Constantin, Jean-Michel; Assefi, Mona; Lecore, Marine; Selves, Agathe; Lamer, Christian; Shi, Ruiying; Knani, Lyes; Floury, Sébastien Pili; Vettoretti, Lucie; Levy, Michael; Marsac, Lucile; Dauger, Stéphane; Guilmin-Crépon, Sophie; Winiszewski, Hadrien; Piton, Gael; Soumagne, Thibaud; Capellier, Gilles; Putegnat, Jean-Baptiste; Bayle, Frédérique; Perrou, Maya; Thao, Ghyslaine; Géri, Guillaume; Charron, Cyril; Repessé, Xavier; Vieillard-Baron, Antoine; Guilbart, Mathieu; Roger, Pierre-Alexandre; Hinard, Sébastien; Macq, Pierre-Yves; Chaulier, Kevin; Goutte, Sylvie; Chillet, Patrick; Pitta, Anaïs; Darjent, Barbara; Bruneau, Amandine; Lasocki, Sigismond; Leger, Maxime; Gergaud, Soizic; Lemarie, Pierre; Terzi, Nicolas; Schwebel, Carole; Dartevel, Anaïs; Galerneau, Louis-Marie; Diehl, Jean-Luc; Hauw-Berlemont, Caroline; Péron, Nicolas; Guérot, Emmanuel; Amoli, Abolfazl Mohebbi; Benhamou, Michel; Deyme, Jean-Pierre; Andremont, Olivier; Lena, Diane; Cady, Julien; Causeret, Arnaud; de la Chapelle, Arnaud; Cracco, Christophe; Rouleau, Stéphane; Schnell, David; Foucault, Camille; Lory, Cécile; Chapelle, Thibault; Bruckert, Vincent; Garcia, Julie; Sahraoui, Abdlazize; Abbosh, Nathalie; Bornstain, Caroline; Pernet, Pierre; Poirson, Florent; Pasem, Ahmed; Karoubi, Philippe; Poupinel, Virginie; Gauthier, Caroline; Bouniol, François; Feuchere, Philippe; Heron, Anne; Carreira, Serge; Emery, Malo; Le Floch, Anne Sophie; Giovannangeli, Luana; Herzog, Nicolas; Giacardi, Christophe; Baudic, Thibaut; Thill, Chloé; Tubach, Florence; Bonnet, Nicolas; Ebstein, Nathan; Gaudry, Stéphane; Cohen, Yves; Noublanche, Julie; Lesieur, Olivier; Sément, Arnaud; Roca-Cerezo, Isabel; Pascal, Michel; Sma, Nesrine; Colin, Gwenhaël; Lacherade, Jean-Claude; Bionz, Gauthier; Maquigneau, Natacha; Bouzat, Pierre; Durand, Michel; Hérault, Marie-Christine; Payen, Jean-Francois |
| Contributors: |
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition CHU Pitié Salpêtrière (IHU ICAN); CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Centre d'investigation clinique Paris Est CHU Pitié Salpêtrière (CIC Paris-Est); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Faculté de Médecine Paris-Saclay; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Saclay; Sorbonne Université - Faculté de Médecine (SU FM); Sorbonne Université (SU); Défaillance Cardiovasculaire Aiguë et Chronique (DCAC); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); Cardiovascular and Renal Clinical Trialists Vandoeuvre-les-Nancy (INI-CRCT); Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu Nancy; Service de Réanimation Médicale CHRU Nancy; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Centre Hospitalier Universitaire d'Angers (CHU Angers); LUNAM Université Nantes Angers Le Mans; CHU Rouen; Normandie Université (NU); Groupe de Recherche sur le Handicap Ventilatoire (GRHV); Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB); Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Hôpital Louis Mourier - AP-HP Colombes; Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord; Centre Hospitalier de Versailles André Mignot (CHV); Centre Hospitalier Universitaire de Martinique Fort-de-France, Martinique (CHU de Martinique); Service de Soins Intensifs CHU Rouen; Centre Hospitalier Henri Mondor d'Aurillac (CH Aurillac); CHU d'Angers Département Urgences; MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC); Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Centre hospitalier régional de Metz-Thionville (CHR Metz-Thionville); GIN Grenoble Institut des Neurosciences (GIN); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA); Université Grenoble Alpes (UGA); This study was funded by the Fondation APHP and its donators though the program “Alliance Tous Unis Contre le Virus,” the Direction de la Recherche Clinique et du Développement, and the French Ministry of Health. The Reseau European de recherche en Ventilation Artificielle (REVA) network received a 75,000 € research grant from Air Liquide Healthcare. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.; COVID-ICU group, for the REVA network, COVID-ICU investigators |
| Source: |
ISSN: 1364-8535. |
| Publisher Information: |
CCSD; BioMed Central |
| Publication Year: |
2021 |
| Subject Terms: |
Acute respiratory failure; Acute respiratory distress syndrome; Outcome; Mortality; Mechanical ventilation; Intubation; High-flow nasal cannula; COVID-19; MESH: COVID-19* / therapy; MESH: Hospitals; MESH: Humans; MESH: Intensive Care Units; MESH: Noninvasive Ventilation; MESH: Prospective Studies; MESH: Risk Assessment; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; Rational: To evaluate the respective impact of standard oxygen, high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) on oxygenation failure rate and mortality in COVID-19 patients admitted to intensive care units (ICUs).Methods: Multicenter, prospective cohort study (COVID-ICU) in 137 hospitals in France, Belgium, and Switzerland. Demographic, clinical, respiratory support, oxygenation failure, and survival data were collected. Oxygenation failure was defined as either intubation or death in the ICU without intubation. Variables independently associated with oxygenation failure and Day-90 mortality were assessed using multivariate logistic regression.Results: From February 25 to May 4, 2020, 4754 patients were admitted in ICU. Of these, 1491 patients were not intubated on the day of ICU admission and received standard oxygen therapy (51%), HFNC (38%), or NIV (11%) (P < 0.001). Oxygenation failure occurred in 739 (50%) patients (678 intubation and 61 death). For standard oxygen, HFNC, and NIV, oxygenation failure rate was 49%, 48%, and 60% (P < 0.001). By multivariate analysis, HFNC (odds ratio [OR] 0.60, 95% confidence interval [CI] 0.36-0.99, P = 0.013) but not NIV (OR 1.57, 95% CI 0.78-3.21) was associated with a reduction in oxygenation failure). Overall 90-day mortality was 21%. By multivariable analysis, HFNC was not associated with a change in mortality (OR 0.90, 95% CI 0.61-1.33), while NIV was associated with increased mortality (OR 2.75, 95% CI 1.79-4.21, P < 0.001).Conclusion: In patients with COVID-19, HFNC was associated with a reduction in oxygenation failure without improvement in 90-day mortality, whereas NIV was associated with a higher mortality in these patients. Randomized controlled trials are needed. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34879857; PUBMED: 34879857; PUBMEDCENTRAL: PMC8653629 |
| DOI: |
10.1186/s13054-021-03784-2 |
| Availability: |
https://hal.science/hal-04821041; https://hal.science/hal-04821041v1/document; https://hal.science/hal-04821041v1/file/Schmidt_2021.pdf; https://doi.org/10.1186/s13054-021-03784-2 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.D99F6F1A |
| Database: |
BASE |